Specificity, stability, and potency of monocyclic .beta.-lactam inhibitors of human leukocyte elastase

Biochemistry ◽  
1992 ◽  
Vol 31 (35) ◽  
pp. 8160-8170 ◽  
Author(s):  
W. B. Knight ◽  
B. G. Green ◽  
R. M. Chabin ◽  
P. Gale ◽  
A. L. Maycock ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution

1993 ◽  
Vol 36 (6) ◽  
pp. 771-777 ◽  
Author(s):  
William K. Hagmann ◽  
Amy L. Kissinger ◽  
Shrenik K. Shah ◽  
Paul E. Finke ◽  
Conrad P. Dorn ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase ◽  
Orally Active

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

1992 ◽  
Vol 35 (21) ◽  
pp. 3745-3754 ◽  
Author(s):  
Shrenik K. Shah ◽  
Conrad P. Dorn ◽  
Paul E. Finke ◽  
Jeffrey J. Hale ◽  
William K. Hagmann ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Elastase 1 ◽  
Human Leukocyte Elastase ◽  
Orally Active

Design, Synthesis, and Enzymatic Evaluation ofN1-Acyloxyalkyl- andN1-Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase

2005 ◽  
Vol 48 (15) ◽  
pp. 4861-4870 ◽  
Author(s):  
Rui Moreira ◽  
Ana Bela Santana ◽  
Jim Iley ◽  
João Neres ◽  
Kenneth T. Douglas ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase

ChemInform Abstract: FR901451, a Novel Inhibitor of Human Leukocyte Elastase from Flexibacter sp. Part 2. Pharmacological Effect of FR901451.

ChemInform ◽  
2010 ◽  
Vol 26 (23) ◽  
pp. no-no
Author(s):  
T. FUJITA ◽  
Y. SHINGUH ◽  
A. YAMAZAKI ◽  
K. NAKAHARA ◽  
M. OKAMOTO ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Pharmacological Effect ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Heterocyclic inhibitors of human leukocyte elastase: 3-Hydroxypyridazopyrimidine, 3-hydroxypyridopyrimidine and 3-hydroxyquinazoline-2,4-1H,3H0dione derivatives

1993 ◽  
Vol 3 (6) ◽  
pp. 1163-1168 ◽  
Author(s):  
William C. Groutas ◽  
James C. Castrisos ◽  
Michael A. Stanga ◽  
Rong-ze Kuang ◽  
Radhika Venkataraman ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase
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