(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist

Robert A. Daines; Pamela A. Chambers; Israil Pendrak; Dalia R. Jakas; Henry M. Sarau; James J. Foley; Dulcie B. Schmidt; Don E. Griswold; Lenox D. Martin

doi:10.1021/jm00070a015

(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm00070a015 ◽

1993 ◽

Vol 36 (18) ◽

pp. 2703-2705 ◽

Cited By ~ 5

Author(s):

Robert A. Daines ◽

Pamela A. Chambers ◽

Israil Pendrak ◽

Dalia R. Jakas ◽

Henry M. Sarau ◽

...

Keyword(s):

Benzoic Acid ◽

Receptor Antagonist ◽

Leukotriene B4 ◽

High Affinity ◽

Leukotriene B4 Receptor

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Synthetic and Structure/Activity Studies on Acid-Substituted 2-Arylphenols: Discovery of 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]- propoxy]phenoxy]benzoic Acid, a High-Affinity Leukotriene B4 Receptor Antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm00022a006 ◽

1995 ◽

Vol 38 (22) ◽

pp. 4411-4432 ◽

Cited By ~ 30

Author(s):

J. Scott Sawyer ◽

Nicholas J. Bach ◽

S. Richard Baker ◽

Ronald F. Baldwin ◽

Peter S. Borromeo ◽

...

Keyword(s):

Benzoic Acid ◽

Receptor Antagonist ◽

Leukotriene B4 ◽

High Affinity ◽

Structure Activity ◽

Leukotriene B4 Receptor

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ChemInform Abstract: Synthetic and Structure-Activity Studies on Acid-Substituted 2- Arylphenols: Discovery of 2-(2-Propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)- 5-hydroxyphenoxy)propoxy)phenoxy)benzoic Acid, a High-Affinity Leukotriene B4 Receptor Antagonist.

ChemInform ◽

10.1002/chin.199610155 ◽

2010 ◽

Vol 27 (10) ◽

pp. no-no

Author(s):

J. S. SAWYER ◽

N. J. BACH ◽

S. R. BAKER ◽

R. F. BALDWIN ◽

P. S. BORROMEO ◽

...

Keyword(s):

Benzoic Acid ◽

Receptor Antagonist ◽

Leukotriene B4 ◽

High Affinity ◽

Structure Activity ◽

Leukotriene B4 Receptor

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Improved Synthesis of RG-14893, a High-Affinity Leukotriene B4 Receptor Antagonist, via a Photochemical Wolff Rearrangement

The Journal of Organic Chemistry ◽

10.1021/jo00115a047 ◽

1995 ◽

Vol 60 (10) ◽

pp. 3249-3251 ◽

Cited By ~ 16

Author(s):

Israil Pendrak ◽

Pamela A. Chambers

Keyword(s):

Receptor Antagonist ◽

Leukotriene B4 ◽

Wolff Rearrangement ◽

High Affinity ◽

Leukotriene B4 Receptor

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ChemInform Abstract: Improved Synthesis of RG-14893 (VIII), a High-Affinity Leukotriene B4 Receptor Antagonist, via a Photochemical Wolff Rearrangement.

ChemInform ◽

10.1002/chin.199539267 ◽

2010 ◽

Vol 26 (39) ◽

pp. no-no

Author(s):

I. PENDRAK ◽

P. A. CHAMBERS

Keyword(s):

Receptor Antagonist ◽

Leukotriene B4 ◽

Wolff Rearrangement ◽

High Affinity ◽

Leukotriene B4 Receptor

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Blockade of human neutrophil activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid (LY293111), a novel leukotriene B4 receptor antagonist

Biochemical Pharmacology ◽

10.1016/0006-2952(95)00078-e ◽

1995 ◽

Vol 49 (11) ◽

pp. 1683-1690 ◽

Cited By ~ 31

Author(s):

Philip Marder ◽

J.Scott Sawyer ◽

Larry L. Froelich ◽

Larry L. Mann ◽

Stephen M. Spaethe

Keyword(s):

Benzoic Acid ◽

Receptor Antagonist ◽

Human Neutrophil ◽

Leukotriene B4 ◽

Neutrophil Activation ◽

Leukotriene B4 Receptor

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(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid and Related Compounds: High Affinity Leukotriene B4 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm00046a017 ◽

1994 ◽

Vol 37 (20) ◽

pp. 3327-3336 ◽

Cited By ~ 10

Author(s):

Robert A. Daines ◽

Pamela A. Chambers ◽

Drake S. Eggleston ◽

James J. Foley ◽

Don E. Griswold ◽

...

Keyword(s):

Benzoic Acid ◽

Leukotriene B4 ◽

Receptor Antagonists ◽

High Affinity ◽

Leukotriene B4 Receptor ◽

Related Compounds

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4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2-naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm00100a034 ◽

1992 ◽

Vol 35 (22) ◽

pp. 4253-4255 ◽

Cited By ~ 18

Author(s):

Fu Chih Huang ◽

Wan Kit Chan ◽

James D. Warus ◽

Mathew M. Morrissette ◽

Kevin J. Moriarty ◽

...

Keyword(s):

Receptor Antagonist ◽

Leukotriene B4 ◽

High Affinity ◽

Leukotriene B4 Receptor ◽

Orally Active

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ChemInform Abstract: (E)-3-(6-(((2,6-Dichlorophenyl)thio)methyl)-3-(2-phenylethoxy)-2- pyridinyl)-2-propenoic Acid (VII): A High-Affinity Leukotriene B4 Receptor Antagonist with Oral Antiinflammatory Activity.

ChemInform ◽

10.1002/chin.199703183 ◽

2010 ◽

Vol 28 (3) ◽

pp. no-no

Author(s):

R. A. DAINES ◽

P. A. CHAMBERS ◽

J. J. FOLEY ◽

D. E. GRISWOLD ◽

W. D. KINGSBURY ◽

...

Keyword(s):

Receptor Antagonist ◽

Antiinflammatory Activity ◽

Leukotriene B4 ◽

High Affinity ◽

Propenoic Acid ◽

Leukotriene B4 Receptor

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ChemInform Abstract: The Synthesis of an Aminohexyl-Containing Analogue of the Chromanol Leukotriene B4 Receptor Antagonist CP-195543: A Scaffold for the Preparation of Derivatized Analogues.

ChemInform ◽

10.1002/chin.200047135 ◽

2000 ◽

Vol 31 (47) ◽

pp. no-no

Author(s):

Brian P. Jones ◽

Klaas Schildknegt ◽

Kathyrn F. Wright ◽

Henry J. Showell ◽

James P. Dittami ◽

...

Keyword(s):

Receptor Antagonist ◽

Leukotriene B4 ◽

Leukotriene B4 Receptor

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Effect of leukotriene B4 receptor antagonist (ONO4057) on hepatic allografting in rats

Transplantation Proceedings ◽

10.1016/s0041-1345(00)01690-0 ◽

2000 ◽

Vol 32 (7) ◽

pp. 2340 ◽

Cited By ~ 5

Author(s):

M Tanaka ◽

T Tamaki ◽

Y Konoeda ◽

Y Uchida ◽

T Kaizu ◽

...

Keyword(s):

Receptor Antagonist ◽

Leukotriene B4 ◽

Leukotriene B4 Receptor

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