Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists

Eric Nicolai; Joel Goyard; Thierry Benchetrit; Jean Marie Teulon; Francois Caussade; Angela Virone; Chantal Delchambre; Alix Cloarec

doi:10.1021/jm00061a008

Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm00061a008 ◽

1993 ◽

Vol 36 (9) ◽

pp. 1175-1187 ◽

Cited By ~ 26

Author(s):

Eric Nicolai ◽

Joel Goyard ◽

Thierry Benchetrit ◽

Jean Marie Teulon ◽

Francois Caussade ◽

...

Keyword(s):

Thromboxane A2 ◽

Receptor Antagonists ◽

Thromboxane A2 Receptor ◽

Structure Activity Relationships ◽

Structure Activity

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Thromboxane Synthase Inhibitors and Thromboxane A2 Receptor Antagonists: A Quantitative Structure Activity Relationships (QSARs) Analysis

Current Medicinal Chemistry ◽

10.2174/092986710792231978 ◽

2010 ◽

Vol 17 (28) ◽

pp. 3162-3214 ◽

Cited By ~ 17

Author(s):

C. Kontogiorgis ◽

D. Hadjipavlou-Litina

Keyword(s):

Thromboxane A2 ◽

Quantitative Structure ◽

Receptor Antagonists ◽

Thromboxane Synthase ◽

Thromboxane A2 Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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ChemInform Abstract: Four-Dimensional Quantitative Structure-Activity Relationship Analysis of a Series of Interphenylene 7-Oxabicycloheptane Oxazole Thromboxane A2 Receptor Antagonists.

ChemInform ◽

10.1002/chin.199905249 ◽

2010 ◽

Vol 30 (5) ◽

pp. no-no

Author(s):

M. G. ALBUQUERQUE ◽

A. J. HOPFINGER ◽

E. J. BARREIRO ◽

R. B. DE ALENCASTRO

Keyword(s):

Thromboxane A2 ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Receptor Antagonists ◽

Thromboxane A2 Receptor ◽

Relationship Analysis ◽

Structure Activity

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Synthesis, Molecular Pharmacology, and Structure–Activity Relationships of 3-(Indanoyl)indoles as Selective Cannabinoid Type 2 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00442 ◽

2021 ◽

Author(s):

Harvey F. Fulo ◽

Amal Shoeib ◽

Christian V. Cabanlong ◽

Alexander H. Williams ◽

Chang-Guo Zhan ◽

...

Keyword(s):

Molecular Pharmacology ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and Structure−Activity Relationships of 2-Substitutedd-Tryptophan-Containing Peptidic Endothelin Receptor Antagonists: Importance of the C-2 Substituent of thed-Tryptophan Residue for Endothelin A and B Receptor Subtype Selectivity

Journal of Medicinal Chemistry ◽

10.1021/jm9600914 ◽

1996 ◽

Vol 39 (12) ◽

pp. 2313-2330 ◽

Cited By ~ 14

Author(s):

Takehiro Fukami ◽

Takeru Yamakawa ◽

Kenji Niiyama ◽

Hisaki Kojima ◽

Yuuka Amano ◽

...

Keyword(s):

Tryptophan Residue ◽

Receptor Subtype ◽

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Subtype Selectivity ◽

Structure Activity ◽

Endothelin A

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Selective endothelin A receptor antagonists. 2. Discovery and structure-activity relationships of 5-ketopentanoic acid derivatives

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(97)84014-7 ◽

1997 ◽

Vol 32 (6) ◽

pp. 515-522 ◽

Cited By ~ 8

Author(s):

P.C. Astles ◽

T.J. Brown ◽

N.V. Harris ◽

M.F. Harper ◽

C McCarthy ◽

...

Keyword(s):

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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Synthesis and structure–activity relationships of ( R )-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.02.004 ◽

2004 ◽

Vol 14 (9) ◽

pp. 2269-2274 ◽

Cited By ~ 14

Author(s):

Martin W Rowbottom ◽

Fabio C Tucci ◽

Yun-Fei Zhu ◽

Zhiqiang Guo ◽

Timothy D Gross ◽

...

Keyword(s):

Gnrh Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Thromboxane A2 receptor antagonists

Medicinal Research Reviews ◽

10.1002/med.2610110504 ◽

1991 ◽

Vol 11 (5) ◽

pp. 503-579 ◽

Cited By ~ 60

Author(s):

Steven E. Hall

Keyword(s):

Thromboxane A2 ◽

Receptor Antagonists ◽

Thromboxane A2 Receptor

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A Novel Dual Antagonist of Thromboxane A2 and Leukotriene D4 Receptors: Synthesis and Structure–Activity Relationships of Chloroquinolylvinyl Derivatives

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.54.603 ◽

2006 ◽

Vol 54 (5) ◽

pp. 603-610 ◽

Cited By ~ 7

Author(s):

Yoshinori Okamoto ◽

Masaki Yokota ◽

Soichiro Kawazoe ◽

Hirokazu Kubota ◽

Hitoshi Nagaoka ◽

...

Keyword(s):

Thromboxane A2 ◽

Leukotriene D4 ◽

Structure Activity Relationships ◽

Structure Activity

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Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm040058e ◽

2004 ◽

Vol 47 (19) ◽

pp. 4787-4798 ◽

Cited By ~ 91

Author(s):

Chen ◽

Keith M. Wilcoxen ◽

Charles Q. Huang ◽

Yun-Feng Xie ◽

James R. McCarthy ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.05.051 ◽

2004 ◽

Vol 14 (15) ◽

pp. 4099-4102 ◽

Cited By ~ 31

Author(s):

Rosa Arienzo ◽

David E Clark ◽

Sue Cramp ◽

Stephen Daly ◽

Hazel J Dyke ◽

...

Keyword(s):

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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