Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury

1994 ◽  
Vol 37 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Yousuke Katsura ◽  
Yoshikazu Inoue ◽  
Tetsuo Tomishi ◽  
Hirohumi Ishikawa ◽  
Hisashi Takasugi
Keyword(s):  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
Drug Induced ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Antiulcer Drugs

scholarly journals Studies on Antiulcer Drugs. VI. 4-Furyl-2-guanidinothiazoles and Related Compounds as Potent Histamine H2-Receptor Antagonists.

1992 ◽  
Vol 40 (9) ◽  
pp. 2432-2441 ◽  
Author(s):  
Yousuke KATSURA ◽  
Yoshikazu INOUE ◽  
Tetsuo TOMISI ◽  
Harunobu ITOH ◽  
Hirohumi ISHIKAWA ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Antiulcer Drugs ◽  
Related Compounds

scholarly journals Histamine H2-Receptor Antagonists Improve Non-Steroidal Anti-Inflammatory Drug-Induced Intestinal Dysbiosis

2020 ◽  
Vol 21 (21) ◽  
pp. 8166
Author(s):  
Rei Kawashima ◽  
Shun Tamaki ◽  
Fumitaka Kawakami ◽  
Tatsunori Maekawa ◽  
Takafumi Ichikawa
Keyword(s):  
Side Effect ◽  
High Performance ◽  
Intestinal Flora ◽  
Receptor Antagonists ◽  
Concurrent Administration ◽  
H2 Receptor Antagonists ◽  
Drug Induced ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Anti Inflammatory

Dysbiosis, an imbalance of intestinal flora, can cause serious conditions such as obesity, cancer, and psychoneurological disorders. One cause of dysbiosis is inflammation. Ulcerative enteritis is a side effect of non-steroidal anti-inflammatory drugs (NSAIDs). To counteract this side effect, we proposed the concurrent use of histamine H2 receptor antagonists (H2RA), and we examined the effect on the intestinal flora. We generated a murine model of NSAID-induced intestinal mucosal injury, and we administered oral H2RA to the mice. We collected stool samples, compared the composition of intestinal flora using terminal restriction fragment length polymorphism, and performed organic acid analysis using high-performance liquid chromatography. The intestinal flora analysis revealed that NSAID [indomethacin (IDM)] administration increased Erysipelotrichaceae and decreased Clostridiales but that both had improved with the concurrent administration of H2RA. Fecal levels of acetic, propionic, and n-butyric acids increased with IDM administration and decreased with the concurrent administration of H2RA. Although in NSAID-induced gastroenteritis the proportion of intestinal microorganisms changes, leading to the deterioration of the intestinal environment, concurrent administration of H2RA can normalize the intestinal flora.

Drugs from emasculated hormones: The principle of syntopic antagonism

1989 ◽  
Vol 9 (3) ◽  
pp. 253-272 ◽  
Author(s):  
James Black
Keyword(s):  
Future Research ◽  
Receptor Antagonists ◽  
Personal View ◽  
H2 Receptor Antagonists ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Early Stages ◽  
Β Receptor

This lecture outlines the early stages in the discovery of adrenaline β-receptor antagonists and of the histamine H2-receptor antagonists. It ends with a brief personal view about future research.

(Imidazolylphenyl)formamidines. A structurally novel class of potent histamine H2 receptor antagonists

1984 ◽  
Vol 27 (3) ◽  
pp. 380-386 ◽  
Author(s):  
Arturo Donetti ◽  
Enzo Cereda ◽  
Elio Bellora ◽  
Alberto Gallazzi ◽  
Cesare Bazzano ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
Histamine H2 Receptor ◽  
H2 Receptor
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