Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors

1995 ◽  
Vol 38 (15) ◽  
pp. 2893-2905 ◽  
Author(s):  
Aurash Shahripour ◽  
James S. Kaltenbronn ◽  
Elizabeth A. Lunney ◽  
Bruce A. Steinbaugh ◽  
James M. Hamby ◽  
...  
Keyword(s):  
Transition State ◽  
Side Chains ◽  
Renin Inhibitors ◽  
Design And Synthesis ◽  
Binding Pockets

Design and Synthesis of G-Quadruplex Ligands Bearing Macrocyclic Hexaoxazoles with Four-Way Side Chains

Heterocycles ◽  
2012 ◽  
Vol 84 (1) ◽  
pp. 401 ◽  
Author(s):  
Kazuo Nagasawa ◽  
Keisuke Iida ◽  
Satoki Majima ◽  
Terumi Ohtake ◽  
Masayuki Tera ◽  
...  
Keyword(s):  
Side Chains ◽  
Design And Synthesis ◽  
G Quadruplex

Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond

1989 ◽  
Vol 32 (7) ◽  
pp. 1652-1661 ◽  
Author(s):  
Mark C. Allen ◽  
Walter Fuhrer ◽  
Brian Tuck ◽  
Roy Wade ◽  
Jeanette M. Wood
Keyword(s):  
Transition State ◽  
Phosphorus Acid ◽  
Transition State Analog ◽  
Renin Inhibitors ◽  
Scissile Bond

scholarly journals Synthesis and structure-activity relationships of human renin inhibitors designed from angiotensinogen transition state.

1990 ◽  
Vol 38 (9) ◽  
pp. 2487-2493 ◽  
Author(s):  
Kinji IIZUKA ◽  
Tetsuhide KAMIJO ◽  
Hiromu HARADA ◽  
Kenji AKAHANE ◽  
Tetsuhiro KUBOTA ◽  
...  
Keyword(s):  
Transition State ◽  
Renin Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Human Renin

Renin inhibitors. Dipeptide analogs of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency

1988 ◽  
Vol 31 (12) ◽  
pp. 2264-2276 ◽  
Author(s):  
Jay R. Luly ◽  
Nwe BaMaung ◽  
Jeff Soderquist ◽  
Anthony K. L. Fung ◽  
Herman Stein ◽  
...  
Keyword(s):  
Transition State ◽  
Inhibitory Potency ◽  
Renin Inhibitors ◽  
Scissile Bond

Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogs of angiotensinogen

1988 ◽  
Vol 31 (2) ◽  
pp. 284-295 ◽  
Author(s):  
Hing L. Sham ◽  
Giorgio Bolis ◽  
Herman H. Stein ◽  
Stephen W. Fesik ◽  
Patrick A. Marcotte ◽  
...  
Keyword(s):  
Renin Inhibitors ◽  
Conformationally Restricted ◽  
Design And Synthesis ◽  
New Class ◽  
Conformationally Restricted Analogs

Design and synthesis of potent macrocyclic renin inhibitors

2011 ◽  
Vol 21 (1) ◽  
pp. 358-362 ◽  
Author(s):  
Christian Sund ◽  
Oscar Belda ◽  
Daniel Wiktelius ◽  
Christer Sahlberg ◽  
Lotta Vrang ◽  
...  
Keyword(s):  
Renin Inhibitors ◽  
Design And Synthesis

Renin inhibitors. Dipeptide analogs of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond

1987 ◽  
Vol 30 (10) ◽  
pp. 1729-1737 ◽  
Author(s):  
Giorgio Bolis ◽  
Anthony K. L. Fung ◽  
Jonathan Greer ◽  
Hollis D. Kleinert ◽  
Patrick A. Marcotte ◽  
...  
Keyword(s):  
Transition State ◽  
Renin Inhibitors ◽  
Scissile Bond
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