26-Week Oral Safety Study in Macaques for Transgenic Rice Containing Major Human T-Cell Epitope Peptides from Japanese Cedar Pollen Allergens

2009 ◽  
Vol 57 (12) ◽  
pp. 5633-5638 ◽  
Author(s):  
Eiji Domon ◽  
Hidenori Takagi ◽  
Sakiko Hirose ◽  
Koichi Sugita ◽  
Saori Kasahara ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Rice ◽  
Cell Epitope ◽  
Japanese Cedar ◽  
T Cell Epitope ◽  
Pollen Allergens ◽  
Safety Study ◽  
Human T Cell ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen

Oral administration of a T cell epitope inhibits symptoms and reactions of allergic rhinitis in Japanese cedar pollen allergen-sensitized mice

2005 ◽  
Vol 510 (1-2) ◽  
pp. 143-148 ◽  
Author(s):  
Takako Murasugi ◽  
Yasuhiro Nakagami ◽  
Tomomi Yoshitomi ◽  
Kazuki Hirahara ◽  
Makoto Yamashita ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
T Cell ◽  
Oral Administration ◽  
Cell Epitope ◽  
Japanese Cedar ◽  
Pollen Allergen ◽  
T Cell Epitope ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen

scholarly journals T‐cell activation by transgenic rice seeds expressing the genetically modified Japanese cedar pollen allergens

Immunology ◽  
2019 ◽  
Vol 158 (2) ◽  
pp. 94-103
Author(s):  
Shinya Takaishi ◽  
Saburo Saito ◽  
Tomonori Endo ◽  
Daiya Asaka ◽  
Yuhya Wakasa ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Rice ◽  
T Cell Activation ◽  
Cell Activation ◽  
Genetically Modified ◽  
Japanese Cedar ◽  
Pollen Allergens ◽  
Japanese Cedar Pollen ◽  
Rice Seeds ◽  
Cedar Pollen

Preclinical evaluation of an immunotherapeutic peptide comprising 7 T-cell determinants of Cry j 1 and Cry j 2, the major Japanese cedar pollen allergens

2001 ◽  
Vol 108 (1) ◽  
pp. 94-100 ◽  
Author(s):  
Kazuki Hirahara ◽  
Toru Tatsuta ◽  
Toshiro Takatori ◽  
Masahiko Ohtsuki ◽  
Hideyo Kirinaka ◽  
...  
Keyword(s):  
T Cell ◽  
Japanese Cedar ◽  
Pollen Allergens ◽  
Preclinical Evaluation ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen ◽  
Cry J 2

Immunoregulatory T cell epitope peptides for the treatment of allergic disease

Immunotherapy ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 1283-1291
Author(s):  
Rashi Ramchandani ◽  
Lubnaa Hossenbaccus ◽  
Anne K Ellis
Keyword(s):  
Allergic Rhinitis ◽  
T Cell ◽  
Treatment Algorithm ◽  
Cell Epitope ◽  
Japanese Cedar ◽  
Allergic Diseases ◽  
T Cell Epitope ◽  
Inflammatory Reactions ◽  
Cedar Pollen

Allergic diseases are type 2 inflammatory reactions with an increasing worldwide prevalence, making the search for new therapeutic options pertinent. Allergen immunotherapy is the only disease-modifying approach for allergic rhinitis, though it can result in systemic reactions. Recently, peptide immunotherapy (PIT), involving T-cell epitope peptides that bind to major histocompatibility complexes, have been developed. It is speculated that they can induce T helper cell type 2 anergy, Treg cell upregulation or immune deviation. Promising results in cat dander, honeybee venom, Japanese cedar pollen, grass pollens, ragweed and house dust mite clinical trials have shown safety, efficacy and tolerability to PIT. Hence, PIT may hold the potential to change the treatment algorithm for allergic rhinitis.

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