Influence of Heat on Biological Activity and Concentration of Oleocanthala Natural Anti-inflammatory Agent in Virgin Olive Oil

2009 ◽  
Vol 57 (4) ◽  
pp. 1326-1330 ◽  
Author(s):  
Sara Cicerale ◽  
Xavier A. Conlan ◽  
Neil W. Barnett ◽  
Andrew J. Sinclair ◽  
Russell S. J. Keast
Keyword(s):  
Biological Activity ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Inflammatory Agent ◽  
Anti Inflammatory

scholarly journals Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1016
Author(s):  
Stefania De Santis ◽  
Marina Liso ◽  
Giulio Verna ◽  
Francesca Curci ◽  
Gualtiero Milani ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Adaptive Immune Response ◽  
Extra Virgin Olive Oil ◽  
Pattern Correlation ◽  
Important Health ◽  
Health Promoting ◽  
Anti Inflammatory ◽  
Inflammatory Profile

Extra virgin olive oil (EVOO) represents one of the most important health-promoting foods whose antioxidant and anti-inflammatory activities are mainly associated to its polyphenols content. To date, studies exploring the effect of EVOO polyphenols on dendritic cells (DCs), acting as a crosstalk between the innate and the adaptive immune response, are scanty. Therefore, we studied the ability of three EVOO extracts (cv. Coratina, Cima di Mola/Coratina, and Casaliva), characterized by different polyphenols amount, to regulate DCs maturation in resting conditions or after an inflammatory stimulus. Cima di Mola/Coratina and Casaliva extracts were demonstrated to be the most effective in modulating DCs toward an anti-inflammatory profile by reduction of TNF and IL-6 secretion and CD86 expression, along with a down-modulation of Il-1β and iNOS expression. From factorial analysis results, 9 polyphenols were tentatively established to play a synergistic role in modulating DCs inflammatory ability, thus reducing the risk of chronic inflammation.

Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis

2014 ◽  
Vol 25 (12) ◽  
pp. 1275-1281 ◽  
Author(s):  
María Ángeles Rosillo ◽  
María José Alcaraz ◽  
Marina Sánchez-Hidalgo ◽  
José G. Fernández-Bolaños ◽  
Catalina Alarcón-de-la-Lastra ◽  
...  
Keyword(s):  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Experimental Arthritis ◽  
Protective Effects ◽  
Anti Inflammatory

scholarly journals In Vitro Anti-Inflammatory Effects of Phenolic Compounds from Moraiolo Virgin Olive Oil (MVOO) in Brain Cells via Regulating the TLR4/NLRP3 Axis

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4523 ◽  
Author(s):  
Agnese Taticchi ◽  
Stefania Urbani ◽  
Elisabetta Albi ◽  
Maurizio Servili ◽  
Michela Codini ◽  
...  
Keyword(s):  
Olive Oil ◽  
Calcium Binding ◽  
Virgin Olive Oil ◽  
Brain Cells ◽  
Cns Injury ◽  
Microglia Cell ◽  
Pyrin Domain ◽  
Bv2 Microglia ◽  
Anti Inflammatory

Neuroinflammation is a feature of many classic neurodegenerative diseases. In the healthy brain, microglia cells are distributed throughout the brain and are constantly surveilling the central nervous system (CNS). In response to CNS injury, microglia quickly react by secreting a wide array of apoptotic molecules. Virgin olive oil (VOO) is universally recognized as a symbol of the Mediterranean diet. In the current study, using lipopolysaccharide (LPS)-stimulated BV2 microglia, the anti-inflammatory effects of VOO phenolic extracts from Moraiolo cultivar (MVOO-PE) were investigated. The results showed that low concentration of MVOO-PE prevented microglia cell death and attenuated the LPS-induced activation of toll-like receptor 4 (TLR4)/NOD-like receptor pyrin domain-containing-3 (NLRP3) signaling cascade. The levels of TLR4 and NF-kB were diminished, as well as NLRP3 inflammasome and interleukin-1β (IL-1β) production. Cyclooxygenase-2 (COX-2) isoenzyme and ionized calcium binding adaptor molecule 1 (Iba-1) inflammatory mediator were also reduced. By modulating the TLR4/NLRP3 axis, MVOO-PE pretreatment was able to significantly down-regulate the mRNA expression of inflammatory mediators and suppress the cytokine secretion. Finally, we showed protective effect of MVOO-PE in a transwell neuron–microglia co-culture system. In conclusion, these results suggest that MVOO-PE could exerts anti-inflammatory activity on brain cells and become a promising candidate for preventing several neuroinflammatory diseases.

Retraction notice to Polar and apolar extra virgin olive oil and leaf extracts as a promising anti-inflammatory natural treatment for osteoarthritis. ACTHIS_119_4 (2017) 407-416

2018 ◽  
Vol 120 (1) ◽  
pp. 64
Author(s):  
Houda Nsir ◽  
Marta Anna Szychlinska ◽  
Venera Cardile ◽  
Adriana Carol Eleonora Graziano ◽  
Rosanna Avola ◽  
...  
Keyword(s):  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Leaf Extracts ◽  
Natural Treatment ◽  
Anti Inflammatory ◽  
Retraction Notice

Storage of extra virgin olive oil and its effect on the biological activity and concentration of oleocanthal

2013 ◽  
Vol 50 (2) ◽  
pp. 597-602 ◽  
Author(s):  
Sara Cicerale ◽  
Xavier A. Conlan ◽  
Neil W. Barnett ◽  
Russell S.J. Keast
Keyword(s):  
Biological Activity ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil
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