Metabolism of 2,4-dichlorophenoxyacetic acid. VI. Biological properties of amino acid conjugates

1974 ◽  
Vol 22 (2) ◽  
pp. 307-309 ◽  
Author(s):  
Chao-Shieung. Feung ◽  
Ralph O. Mumma ◽  
Robert H. Hamilton
Keyword(s):  
Amino Acid ◽  
Biological Properties ◽  
Dichlorophenoxyacetic Acid ◽  
Amino Acid Conjugates ◽  
2,4 Dichlorophenoxyacetic Acid

Specific Localization of β-ᴅ-Glucoside Conjugates of 2,4-Dichlorophenoxyacetic Acid in Soybean Vacuoles

1982 ◽  
Vol 37 (9) ◽  
pp. 772-777 ◽  
Author(s):  
R. Schmitt ◽  
H. Sandermann
Keyword(s):  
Amino Acid ◽  
Osmotic Shock ◽  
Cell Suspension Cultures ◽  
Dichlorophenoxyacetic Acid ◽  
Cell Wall Degrading Enzymes ◽  
Amino Acid Conjugates ◽  
Specific Localization ◽  
Glycine Max L ◽  
2,4 Dichlorophenoxyacetic Acid ◽  
A Minor

Cell suspension cultures of soybean (Glycine max L.) were incubated with [14C]-2,4- dichlorophenoxyacetic acid (62 h, 27 °C). The cells were converted to protoplasts by use of the cell-wall degrading enzymes, Driselase and pectinase. This procedure resulted in the release of the cellular amino acid conjugates as well as part of the free 2,4-dichlorophenoxyacetic acid and of the β-ᴅ- glucoside conjugates. A vacuole fraction was obtained by mild osmotic shock in 10% yield, and was characterized by its polypeptide composition. The purified vacuoles were enriched in β-ᴅ-glucoside conjugates, free 2,4-dichlorophenoxyacetic acid being only a minor vacuolar constituent, and amino acid conjugates not being detectable.

Synthesis, physical-chemical and biological properties of amphiphilic amino acid conjugates of nitroxides

2010 ◽  
Vol 34 (9) ◽  
pp. 1909 ◽  
Author(s):  
Grégory Durand ◽  
Fanny Choteau ◽  
Robert A. Prosak ◽  
Antal Rockenbauer ◽  
Frederick A. Villamena ◽  
...  
Keyword(s):  
Amino Acid ◽  
Biological Properties ◽  
Amino Acid Conjugates ◽  
Physical Chemical ◽  
Amphiphilic Amino Acid

scholarly journals Biological Properties of d-Amino Acid Conjugates of 2,4-D

1982 ◽  
Vol 70 (2) ◽  
pp. 357-360 ◽  
Author(s):  
Gayle H. Davidonis ◽  
Robert H. Hamilton ◽  
Remo P. Vallejo ◽  
Robert Buly ◽  
Ralph O. Mumma
Keyword(s):  
Amino Acid ◽  
Biological Properties ◽  
Amino Acid Conjugates

scholarly journals NHÂN GIỐNG CÂY GIẢO CỔ LAM (Gynostemma pentaphyllum (Thunb.) Makino) BẰNG NUÔI CẤY CALLUS

2019 ◽  
Vol 128 (1E) ◽  
pp. 59-68
Author(s):  
Hoàng Tấn Quảng ◽  
Lê Phổ Quỳnh Như ◽  
Nguyễn Minh Trí ◽  
Lê Thị Tuyết Nhân ◽  
Lê Như Cương ◽  
...  
Keyword(s):  
Amino Acid ◽  
Dichlorophenoxyacetic Acid ◽  
Naphthaleneacetic Acid ◽  
Gynostemma Pentaphyllum ◽  
2,4 Dichlorophenoxyacetic Acid

Giảo cổ lam (Gynostemma pentaphyllum (Thunb.) Makino) từ lâu đã được sử dụng làm thuốc dân gian cũng như được dùng để chế biến thành trà ở các nước châu Á. Đây là cây thân thảo lâu năm thuộc họ bầu bí chứa saponin, flavonoid, polysaccharide, vitamin và các amino acid. Trong nghiên cứu này, nhân giống in vitro loài cây này thông qua giai đoạn callus đã được thực hiện. Kết quả cho thấy môi trường cảm ứng sinh callus hiệu quả nhất đối với mẫu lá là MS cơ bản có bổ sung 1,5 mg/L NAA (naphthaleneacetic acid), đối với mẫu cuống lá là 0,2 mg/L 2,4-D (2,4-dichlorophenoxyacetic acid), tỷ lệ mẫu có cảm ứng tạo callus tương ứng là 100% và 97,8%. Môi trường tái sinh chồi từ callus cho hiệu quả cao nhất là MS cơ bản có bổ sung 2,0 mg/L BAP (6-Benzylaminopurine) và 0,2 mg/L NAA, tỷ lệ tái sinh chồi đạt 55,6%. Môi trường MS cơ bản bổ sung 1,0 mg/L BAP cho hiệu quả nhân chồi cao nhất đối với chồi đỉnh (6,17 chồi/mẫu) trong khi bổ sung 0,3 mg/L BAP cho hiệu quả cao nhất đối với chồi bên (7,72 chồi/mẫu). Môi trường tạo rễ tốt nhất đối với cây Giảo cổ lam là MS bổ sung 0,5 mg/L NAA với số lượng rễ là 7,22 rễ/chồi.

scholarly journals Novel 2,4-Dichlorophenoxyacetic Acid Degradation Genes from Oligotrophic Bradyrhizobium sp. Strain HW13 Isolated from a Pristine Environment

2002 ◽  
Vol 184 (2) ◽  
pp. 509-518 ◽  
Author(s):  
Wataru Kitagawa ◽  
Sachiko Takami ◽  
Keisuke Miyauchi ◽  
Eiji Masai ◽  
Yoichi Kamagata ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Burkholderia Cepacia ◽  
Ralstonia Eutropha ◽  
Rhodococcus Erythropolis ◽  
Amino Acid Sequences ◽  
Dichlorophenoxyacetic Acid ◽  
Phenol Derivatives ◽  
Degrading Bacteria ◽  
2,4 Dichlorophenoxyacetic Acid

ABSTRACT The tfd genes of Ralstonia eutropha JMP134 are the only well-characterized set of genes responsible for 2,4-dichlorophenoxyacetic acid (2,4-D) degradation among 2,4-D-degrading bacteria. A new family of 2,4-D degradation genes, cadRABKC, was cloned and characterized from Bradyrhizobium sp. strain HW13, a strain that was isolated from a buried Hawaiian soil that has never experienced anthropogenic chemicals. The cadR gene was inferred to encode an AraC/XylS type of transcriptional regulator from its deduced amino acid sequence. The cadABC genes were predicted to encode 2,4-D oxygenase subunits from their deduced amino acid sequences that showed 46, 44, and 37% identities with the TftA and TftB subunits of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) oxygenase of Burkholderia cepacia AC1100 and with a putative ferredoxin, ThcC, of Rhodococcus erythropolis NI86/21, respectively. They are thoroughly different from the 2,4-D dioxygenase gene, tfdA, of R. eutropha JMP134. The cadK gene was presumed to encode a 2,4-D transport protein from its deduced amino acid sequence that showed 60% identity with the 2,4-D transporter, TfdK, of strain JMP134. Sinorhizobium meliloti Rm1021 cells containing cadRABKC transformed several phenoxyacetic acids, including 2,4-D and 2,4,5-T, to corresponding phenol derivatives. Frameshift mutations indicated that each of the cadRABC genes was essential for 2,4-D conversion in strain Rm1021 but that cadK was not. Five 2,4-D degraders, including Bradyrhizobium and Sphingomonas strains, were found to have cadA gene homologs, suggesting that these 2,4-D degraders share 2,4-D degradation genes similar to those of strain HW13 cadABC.

Quercetin-Amino Acid Conjugates are Promising Anti-Cancer Agents in Drug Discovery Projects

2020 ◽  
Vol 20 (2) ◽  
pp. 107-122 ◽  
Author(s):  
Alexey V. Dobrydnev ◽  
Tetiana M. Tkachuk ◽  
Viktor P. Atamaniuk ◽  
Maria V. Popova
Keyword(s):  
Amino Acid ◽  
Structural Diversity ◽  
Pharmacokinetic Profile ◽  
Biological Properties ◽  
Therapeutic Window ◽  
Amino Acid Conjugates ◽  
Anti Cancer ◽  
Resistance Reversal ◽  
Cellular Permeability ◽  
Physicochemical And Biological Properties

Quercetin is a plant flavonoid with great potential for the prevention and treatment of disease. Despite the curative application of quercetin is hampered by low bioavailability, its core serves as a scaffold for generating more potent compounds with amplified therapeutic window. This review aims to describe recent advances in the improvement of the pharmacokinetic profile of quercetin via the amino acid prodrug approach which offers wide structural diversity, physicochemical and biological properties improvement. According to the findings, conjugation of quercetin with amino acids results in increased solubility, stability, cellular permeability as well as biological activity. In particular quercetin- amino acid conjugates exhibited potent anticancer, MDR-reversal and antibiotic resistance reversal activities. The synthetic pathways and examples of quercetin-amino acid conjugates are considered. Practical considerations and challenges associated with the development of these prodrugs are also discussed. This mini-review covers the literature on quercetin-amino acid conjugates since 2001 when the first thematic work was published.

Biological properties of amino acid conjugates of 2,4,5-trichlorophenoxyacetic acid

1979 ◽  
Vol 27 (5) ◽  
pp. 1086-1088 ◽  
Author(s):  
Gayle H. Davidonis ◽  
Masood Arjmand ◽  
Robert H. Hamilton ◽  
Ralph O. Mumma
Keyword(s):  
Amino Acid ◽  
Biological Properties ◽  
Amino Acid Conjugates ◽  
Trichlorophenoxyacetic Acid
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