Depletion of Penicillin G Residues in Heavy Sows after Intramuscular Injection. Part I: Tissue Residue Depletion

2014 ◽  
Vol 62 (30) ◽  
pp. 7577-7585 ◽  
Author(s):  
S. J. Lupton ◽  
W. L. Shelver ◽  
D. J. Newman ◽  
S. Larsen ◽  
D. J. Smith
Keyword(s):  
Intramuscular Injection ◽  
Penicillin G ◽  
Tissue Residue ◽  
Residue Depletion

Tissue Damage Caused by the Intramuscular Injection of Long-Acting Penicillin

PEDIATRICS ◽  
1985 ◽  
Vol 75 (4) ◽  
pp. 741-744
Author(s):  
Harry Schanzer ◽  
Julius H. Jacobson
Keyword(s):  
New Zealand ◽  
Femoral Artery ◽  
Normal Saline ◽  
Tissue Damage ◽  
Intramuscular Injection ◽  
Penicillin G ◽  
Left Femoral Artery ◽  
New Zealand White Rabbits ◽  
Long Acting ◽  
The Right

In order to elucidate whether tissue damage produced on occasion by intramuscular injection of longacting penicillin is due to accidental intra-arterial injection or vasospasm, two types of experiments were carried out in rabbits. In the first set of experiments, six New Zealand White rabbits were given intra-arterial injections of 0.4 mL of a mixture containing 300,000 U of penicillin G benzathine and 300,000 units of penicillin procaine per milliliter (Bicillin C-R) into the left femoral artery and 0.4 mL of normal saline into the right femoral artery as autocontrol. In a second set of experiments, 0.4 mL of the same penicillin preparation was injected in the space surrounding the left femoral artery in five New Zealand rabbits, and 0.4 mL of normal saline was injected in a similar fashion around the right femotal artery as control. The legs of the rabbits that received the intra-arterial injection of penicillin invariably developed ischemic manifestations. None of the legs of rabbits given intra-arterial injections of normal saline had pathologic manifestations. None of the rabbits that received the periarterial penicillin preparation or normal saline developed abnormalities. These results strongly suggest that the tissue damage produced by penicillin is secondary to the intra-arterial administration of the drug.

STUDIES OF PENICILLIN IN PEDIATRICS

PEDIATRICS ◽  
1950 ◽  
Vol 5 (4) ◽  
pp. 664-671
Author(s):  
B. M. KAGAN ◽  
M. NIERENBERG ◽  
D. GOLDBERG ◽  
A. MILZER
Keyword(s):  
Intramuscular Injection ◽  
Room Temperature ◽  
Serum Levels ◽  
Sesame Oil ◽  
Peanut Oil ◽  
Penicillin G ◽  
Procaine Penicillin ◽  
Pertinent Data ◽  
Significant Difference ◽  
Pediatric Use

Table I summarizes most of the pertinent data in this report on the serum penicillin concentrations 12 and 24 hours after intramuscular injection of K penicillin G in peanut oil and beeswax, which is fluid at room temperature, and of three different procaine penicillin preparations. These three preparations are procaine penicillin G in sesame oil, procaine penicillin G in peanut oil with 2% aluminum monostearate, and procaine penicillin G in water with Na-carboxymethylcellulose. When they were given in a dosage of 8000 u./lb. to infants and children, weighing between 4.5 and 18.0 kg., there was no statistically significant difference in the serum levels obtained. A dosage schedule for these preparations is suggested for pediatric use. The aqueous preparation offers some advantages which are discussed. Experiences are reported which emphasize the necessity of avoiding intravenous administration of all these preparations.

Rheumatic Fever Article Questioned

PEDIATRICS ◽  
1984 ◽  
Vol 74 (6) ◽  
pp. 1133-1134
Author(s):  
SYLVIA P. GRIFFITHS
Keyword(s):  
Rheumatic Fever ◽  
Intramuscular Injection ◽  
Group A Streptococcus ◽  
Penicillin G ◽  
Benzathine Penicillin ◽  
Benzathine Penicillin G ◽  
Group A

To the Editor.— The suggestion of Nordin1 that there may be a need to re-evaluate the current recommended prophylaxis for children with rheumatic fever is valid, particularly if carefully planned and controlled studies could be carried out. However, the author's contention that "It has been assumed that the levels of penicillin [following monthly intramuscular injection of 1.2 million units of benzathine penicillin G] are adequate to prevent reinfection with group A streptococcus, and hence to prevent recurrences of rheumatic fever" has always been qualified by others.

Quantitative Evaluation of a Bovine Antibiotic Infusion Product by Milk Residue Depletion Studies

1985 ◽  
Vol 48 (7) ◽  
pp. 611-615 ◽  
Author(s):  
LYSE LAROCQUE ◽  
GEORGE A. NEVILLE
Keyword(s):  
Quantitative Evaluation ◽  
Bovine Mastitis ◽  
Polymyxin B ◽  
Detectable Level ◽  
Penicillin G ◽  
Milk Samples ◽  
Residue Depletion ◽  
Antibiotic Infusion ◽  
Standard Techniques

Cows (six) were treated as for bovine mastitis by an intra-mammary infusion containing penicillin G, streptomycin, neomycin and polymyxin B sulfate. After termination of treatment, milk samples were drawn at intervals of 12 h and assayed for the antibiotics by standard techniques. Residues of penicillin, streptomycin and neomycin were found to persist beyond the milk withholding time of 96 h as stated on the label of the product. Streptomycin residue was found to persist in milk from 50% of the cows beyond 14.5 d, whereas no detectable level of polymyxin B was found in the milk samples. Manufacture of the formulation evaluated in this study was discontinued in 1983.

Pharmacokinetics of benzathine penicillin G: Serum levels during the 28 days after intramuscular injection of 1,200,000 units

1989 ◽  
Vol 115 (1) ◽  
pp. 146-150 ◽  
Author(s):  
Edward L. Kaplan ◽  
Ximena Berrios ◽  
John Speth ◽  
Thomas Siefferman ◽  
B. Guzman ◽  
...  
Keyword(s):  
Intramuscular Injection ◽  
Serum Levels ◽  
Penicillin G ◽  
Benzathine Penicillin ◽  
Benzathine Penicillin G

Patterns of doramectin tissue residue depletion in parasitized vs nonparasitized lambs

2008 ◽  
Vol 102 (5) ◽  
pp. 1051-1057 ◽  
Author(s):  
Rubén Pérez ◽  
Cristina Palma ◽  
Maria José Nuñez ◽  
Ignacio Cabezas
Keyword(s):  
Tissue Residue ◽  
Residue Depletion

Residue depletion in tissues and fluids from swine fed sulfamethazine, chlortetracycline and penicillin G in combination

1996 ◽  
Vol 13 (3) ◽  
pp. 287-292 ◽  
Author(s):  
G. O. Korsrud ◽  
M. G. Papich ◽  
A. C. E. Fesser ◽  
C. D. C. Salisbury ◽  
J. D. Macneil
Keyword(s):  
Penicillin G ◽  
Residue Depletion

scholarly journals Comparison of erythromycin and oxytetracycline for the treatment of ovine footrot

2001 ◽  
Vol 49 (2) ◽  
pp. 131-139 ◽  
Author(s):  
S. Píriz ◽  
T. Pobel ◽  
Ruth Jiménez ◽  
E. M. Mateos ◽  
P. Martín-Palomino ◽  
...  
Keyword(s):  
Success Rate ◽  
Intramuscular Injection ◽  
The Other ◽  
Penicillin G ◽  
Bacterial Isolates ◽  
Microbiological Study ◽  
Dichelobacter Nodosus

A microbiological study of 25 cases of ovine footrot was performed. Cultures belonging to Dichelobacter nodosus were isolated in 48% of the sampled animals. The sensitivity of the 99 strict anaerobic bacterial isolates to 5 antibiotics (penicillin G, amoxycillin, spiramycin, erythromycin and oxytetracycline) was studied. The percentage of resistant cultures was in all cases higher than 30%. The efficacy of erythromycin and oxytetracycline in the treatment of ovine footrot was studied. To conduct this test, an intramuscular injection was applied, of one antimicrobial or the other, at the beginning of the treatment. The tolerance of animals to the antimicrobials, the success rate of treatment and the severity of lameness were evaluated. The percentage of animals cured within 15 days was around 75%. In contrast, only 44% improvement was achieved in the lameness. No differences were found between the two antimicrobials in the above indices.

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