Relevance of Carnosic Acid, Carnosol, and Rosmarinic Acid Concentrations in the in Vitro Antioxidant and Antimicrobial Activities of Rosmarinus officinalis (L.) Methanolic Extracts

2012 ◽  
Vol 60 (38) ◽  
pp. 9603-9608 ◽  
Author(s):  
Maria J. Jordán ◽  
Vanesa Lax ◽  
Maria C. Rota ◽  
Susana Lorán ◽  
José A. Sotomayor
Keyword(s):  
Rosmarinic Acid ◽  
Antimicrobial Activities ◽  
Rosmarinus Officinalis ◽  
Carnosic Acid ◽  
Methanolic Extracts ◽  
Rosmarinus Officinalis L ◽  
Antioxidant And Antimicrobial Activities

scholarly journals Effects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic acid

2019 ◽  
Vol 271 ◽  
pp. 393-400 ◽  
Author(s):  
Geferson A. Gonçalves ◽  
Rúbia C.G. Corrêa ◽  
Lillian Barros ◽  
Maria Inês Dias ◽  
Ricardo C. Calhelha ◽  
...  
Keyword(s):  
Rosmarinic Acid ◽  
Rosmarinus Officinalis ◽  
Gastrointestinal Digestion ◽  
Colonic Fermentation ◽  
In Vitro Gastrointestinal Digestion ◽  
Rosmarinus Officinalis L

scholarly journals Antioxidant Activity Analysis for the Selection of Rosmarinus officinalis L

2006 ◽  
Vol 1 (12) ◽  
pp. 1934578X0600101 ◽  
Author(s):  
Juan Antonio Garbarino ◽  
Nicolás Troncoso ◽  
Pia Delpiano ◽  
Loreto Carvajal ◽  
Alessandra Russo
Keyword(s):  
Antioxidant Activity ◽  
Chemical Composition ◽  
Acid Content ◽  
Radical Scavenging ◽  
Good Method ◽  
Rosmarinus Officinalis ◽  
Carnosic Acid ◽  
Methanolic Extracts ◽  
Rosmarinus Officinalis L ◽  
Selection Of

Rosmarinus officinalis L. presents a high genetic variability, which is reflected in the chemical composition of the different individuals, and consequently in its biological activity, including antioxidant capacity. The aim of the present research was to correlate the chemical composition of methanolic extracts of the dried leaves of eight rosemary accessions with their antioxidant activity for the selection of plants to optimize the use of rosemary. The eight samples examined, starting from a collection of more than 160 individuals selected by BOTANE Ltd, were cultivated at Illapel, north central Chile, using the same cultivation techniques. The free radical-scavenging capacity was tested by the ability of extracts to bleach the stable 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and to inhibit superoxide anion (O2-) and hydroxyl radical (.OH) production. The metal chelating activity was estimated by the ferrozine assay. All extracts (1–8) contained high concentrations of carnosic acid, and to a minor extent rosmarinic acid, and exhibited antioxidant activity. However, extracts 7 and 8, containing 31.7 and 26.1% of carnosic acid, respectively, have shown a higher biological effect, confirming that the antioxidant activity of R. officinalis leaves is primarily related to this phenolic diterpene and suggesting that the measure of antioxidant activity could be considered a good method in the selection of this plant for its optimization. Interestingly, our experimental evidence also suggests that air pollution negatively influences the carnosic acid content. In fact, samples 3 and 4, with a low carnosic acid content, originated from a highly polluted metropolitan area of Santiago city.

scholarly journals ANTIFUNGAL ACTIVITIES OF ETHANOL EXTRACT OF ROSEMARY LEAF (Rosemarinus officinalis L.) AGAINST Candida albicans

2020 ◽  
Vol 2 (1) ◽  
pp. 28
Author(s):  
Dewa Ayu Made Adnya Swari ◽  
I Wayan Martadi Santika ◽  
I Gusti Made Aman
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Rosmarinic Acid ◽  
Extraction Method ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Rosmarinus Officinalis ◽  
Control Group ◽  
Rosmarinus Officinalis L

Background: This study was a preliminary study aimed to investigating the in vitro activity of rosmarinic acid contained on Rosemary leaves (Rosemarinus officinalis L.) on the Candida albicans. Rosmarinic acid can be an inhibitor of the RTPase enzyme in the fungus Candida albicans. Objective: This study is expected to provide information in the development of science about the antifungal activity of ethanol extract of Rosemary leave (Rosmarinus officinalis L.) againsts C.albicans. The recent research was an laboratory experimental. Experiments on an ethanol extract of Rosemary leaves (Rosemarinus officinalis L.) and post-test design of the control group. Methods: The extraction method used in this study was a multilevel extraction method. The antifungal activity testing method uses discs and MIC methods. Replication was done six times at two concentration namely, 80% (b/v) and 100% for each measurement. Results: The data analysis was carried out using SPSS with 95% of confidence level with the Kruskal Wallis analysis then completed with the Mann Whitney U test. The results of the MIC experiment showed all the various concentrations of ethanol extract performed Candida albicans growth on the surface of the media. Extract with 80% (b/v) concentration showed greater antifungal activity. Furthermore the MIC was shown by 80% (b/v) concentration of the ethanol extract of Rosemary leaves against Candida albicans. The test results of the antifungal activity of the Rosemary leaf ethanol extract showed the presence of inhibitory diameter in the ethanol extract of the Rosemary leaf concentration of 80% (b/v) with a mean ± SD of 10.6 ± 0.57735 and RSD of 5.774%. Conclusion: The ethanol extract of Rosemary leaves (Rosmarinus officinalis L.) has an inhibitory effect on the fungus Candida albicans at a concentration of 80% (b / v) Keywords: Antifungal activity, Candida albicans, Rosemary, RTPase, ethanol extract

scholarly journals Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity

2019 ◽  
Vol 9 (1) ◽  
pp. 323-330 ◽  
Author(s):  
Akshay Kompelly ◽  
Swathi Kompelly ◽  
Bakshi Vasudha ◽  
Boggula Narender
Keyword(s):  
Medicinal Plants ◽  
Rosmarinic Acid ◽  
Biological Activities ◽  
Research Work ◽  
Rosmarinus Officinalis ◽  
New Drugs ◽  
Carnosic Acid ◽  
Neuroprotective Activity ◽  
Future Market ◽  
Rosmarinus Officinalis L

Herbal medicine is one of the oldest valuable bestowals that were given to mankind. Many plants and herbs hold their prestigious position in the field of medicine. The worldwide interest in the use of medicinal plants has been growing, and its beneficial effects being rediscovered for the development of new drugs. Based on their vast ethnopharmacological applications, which inspired current research in drug discovery, natural products can provide new and important leads against various pharmacological targets. This work pioneers an extensive and an updated literature review on the current state of research on Rosmarinus officinalis L., elucidating which compounds and biological activities are the most relevant. According to these references, there has been an increasing interest in the therapeutic properties of this plant, regarding carnosic acid, carnosol, rosmarinic acid and the essential oil. The present manuscript provides an updated review upon the most reported activities on R. officinalis and its active constituents. This knowledge about the medicinal plants usage can also be extended to other fields like field of pharmacology. In view of the nature of the plant, more research work can be done on humans so that a drug with multifarious effects will be available in the future market. Keywords: Rosmarinus officinalis, phytochemicals, carnosic acid, rosmarinic acid, neuroprotective activity, anti-diabetic activity.

scholarly journals Within-Plant Variation in Rosmarinus officinalis L. Terpenes and Phenols and Their Antimicrobial Activity against the Rosemary Phytopathogens Alternaria alternata and Pseudomonas viridiflava

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3425
Author(s):  
Maria Bellumori ◽  
Marzia Innocenti ◽  
Federica Congiu ◽  
Gabriele Cencetti ◽  
Aida Raio ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Alternaria Alternata ◽  
Rosmarinic Acid ◽  
Total Concentration ◽  
Rosmarinus Officinalis ◽  
Carnosic Acid ◽  
Plant Variation ◽  
Pseudomonas Viridiflava ◽  
Young Leaves ◽  
Rosmarinus Officinalis L

This study investigated within-plant variability of the main bioactive compounds in rosemary (Rosmarinus officinalis L.). Volatile terpenes, including the enantiomeric distribution of monoterpenes, and phenols were analyzed in young and mature foliar, cortical and xylem tissues. In addition, antimicrobial activity of rosmarinic acid and selected terpenes was evaluated against two rosemary pathogens, Alternaria alternata and Pseudomonas viridiflava. Data showed that total concentration and relative contents of terpenes changed in relation to tissue source and age. Their highest total concentration was observed in the young leaves, followed by mature leaves, cortical and xylem tissues. Rosmarinic acid and carnosic acid contents did not show significant differences between leaf tissues of different ages, while young and mature samples showed variations in the content of four flavonoids. These results are useful for a more targeted harvesting of rosemary plants, in order to produce high-quality essential oils and phenolic extracts. Microbial tests showed that several terpenes and rosmarinic acid significantly inhibited the growth of typical rosemary pathogens. Overall, results on antimicrobial activity suggest the potential application of these natural compounds as biochemical markers in breeding programs aimed to select new chemotypes less susceptible to pathogen attacks, and as eco-friendly chemical alternatives to synthetic pesticides.

scholarly journals Evaluation of Hepatoprotective Activity and Oxidative Stress Reduction of Rosmarinus officinalis L. Shoots Tincture in Rats with Experimentally Induced Hepatotoxicity

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1737 ◽  
Author(s):  
Irina Ielciu ◽  
Bogdan Sevastre ◽  
Neli-Kinga Olah ◽  
Andreea Turdean ◽  
Elisabeta Chișe ◽  
...  
Keyword(s):  
Hepatoprotective Activity ◽  
Rosmarinus Officinalis ◽  
Raw Material ◽  
Carnosic Acid ◽  
Medicinal Uses ◽  
Antioxidant Mechanism ◽  
Rosmarinus Officinalis L ◽  
Experimentally Induced

Rosmarinus officinalis L. is a widely known species for its medicinal uses, that is also used as raw material for the food and cosmetic industry. The aim of the present study was to offer a novel perspective on the medicinal product originating from this species and to test its hepatoprotective activity. The tested sample consisted in a tincture obtained from the fresh young shoots. Compounds that are evaluated for this activity are polyphenols and terpenoids, that are identified and quantified by HPLC–UV–MS and GC–MS. Antioxidant activity was assessed in vitro, using the DPPH, FRAP and SO assays. Hepatoprotective activity was tested in rats with experimentally-induced hepatotoxicity. In the chemical composition of the tincture, phenolic diterpenes (carnosic acid, carnosol, rosmanol, rosmadial) and rosmarinic acid were found to be the majority compounds, alongside with 1,8-cineole, camphene, linalool, borneol and terpineol among monoterpenes. In vitro, the tested tincture proved significant antioxidant capacity. Results of the in vivo experiment showed that hepatoprotective activity is based on an antioxidant mechanism. In this way, the present study offers a novel perspective on the medicinal uses of the species, proving significant amounts of polyphenols and terpenes in the composition of the fresh young shoots tincture, that has proved hepatoprotective activity through an antioxidant mechanism.

The antioxidant and antimicrobial activities of methanolic extracts from houseleek (Sempervivum marmoreum L.) leaves

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
S Stojièević ◽  
I Stanisavljević ◽  
D Velièković ◽  
V Veljković ◽  
M Lazić
Keyword(s):  
Antimicrobial Activities ◽  
Methanolic Extracts ◽  
Antioxidant And Antimicrobial Activities

scholarly journals The Effect of Carnosol, Carnosic Acid and Rosmarinic Acid on the Oxidative Stability of Fat-Filled Milk Powders throughout Accelerated Oxidation Storage

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 762
Author(s):  
Katerina Tzima ◽  
Nigel P. Brunton ◽  
Noel A. McCarthy ◽  
Kieran N. Kilcawley ◽  
David T. Mannion ◽  
...  
Keyword(s):  
Rosmarinic Acid ◽  
Solid Phase ◽  
Thiobarbituric Acid ◽  
Butylated Hydroxytoluene ◽  
Carnosic Acid ◽  
Gas Chromatography Mass Spectrometry ◽  
Peroxide Values ◽  
Antioxidant Potency ◽  
Antioxidant Effects

The in vitro antioxidant effects of the most potent antioxidants of rosemary, namely carnosol, carnosic acid and rosmarinic acid (c: ca: ra) were assessed in fat-filled milk powders (FFMPs) under accelerated conditions (40 °C and relative humidity (RH) 23%) over 90 days. Lipid oxidation was assessed in FFMPs by measuring peroxide values (PVs), thiobarbituric acid reactive substances (TBARS) and aroma volatiles using headspace (HS) solid-phase microextraction (SPME) coupled to gas-chromatography-mass spectrometry (GC-MS). The antioxidant potency of c: ca: ra exhibited a concentration-related effect (308 ppm > 200 ppm > 77 ppm), with the highest concentration being the most effective at controlling the formation of TBARS and PVs. At a concentration of 308 ppm c: ca: ra were particularly effective (p < 0.05) in inhibiting all the evaluated oxidation indices (primary and secondary) compared to the control samples, but in some cases less effectively (p < 0.05) than butylated hydroxyanisole: butylated hydroxytoluene (BHA: BHT) (200 ppm).

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