Inhibition of Advanced Glycation End Product Formation by Pu-erh Tea Ameliorates Progression of Experimental Diabetic Nephropathy

2012 ◽  
Vol 60 (16) ◽  
pp. 4102-4110 ◽  
Author(s):  
Shi-Jun Yan ◽  
Lei Wang ◽  
Zhi Li ◽  
Di-Na Zhu ◽  
Shao-Chen Guo ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Product Formation ◽  
Advanced Glycation ◽  
Advanced Glycation End Product

scholarly journals Diphlorethohydroxycarmalol Attenuates Methylglyoxal-Induced Oxidative Stress and Advanced Glycation End Product Formation in Human Kidney Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Seon-Heui Cha ◽  
Yongha Hwang ◽  
Soo-Jin Heo ◽  
Hee-Sook Jun
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Mrna Expression ◽  
Human Kidney ◽  
Product Formation ◽  
Diabetic Patients ◽  
Kidney Cells ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Hek Cells

Diabetic nephropathy is the leading cause of end-stage renal disease in patients with diabetes mellitus. Oxidative stress has been shown to play an important role in pathogeneses of renal damage in diabetic patients. Here, we investigated the protective effect of diphlorethohydroxycarmalol (DPHC), which is a polyphenol isolated from an edible seaweed, Ishige okamurae, on methylglyoxal-induced oxidative stress in HEK cells, a human embryonic kidney cell line. DPHC treatment inhibited methylglyoxal- (MGO-) induced cytotoxicity and ROS production. DPHC activated the Nrf2 transcription factor and increased the mRNA expression of antioxidant and detoxification enzymes, consequently reducing MGO-induced advanced glycation end product formation. In addition, DPHC increased glyoxalase-1 mRNA expression and attenuated MGO-induced advanced glycation end product formation in HEK cells. These results suggest that DPHC possesses a protective activity against MGO-induced cytotoxicity in human kidney cells by preventing oxidative stress and advanced glycation end product formation. Therefore, it could be used as a potential therapeutic agent for the prevention of diabetic nephropathy.

The inhibitory effect of the catechin structure on advanced glycation end product formation in alcoholic media

2020 ◽  
Vol 11 (6) ◽  
pp. 5396-5408
Author(s):  
Qian Wu ◽  
Shimiao Tang ◽  
Liang Zhang ◽  
Jinsong Xiao ◽  
Qing Luo ◽  
...  
Keyword(s):  
Maillard Reaction ◽  
Product Formation ◽  
Inhibitory Effect ◽  
Advanced Glycation ◽  
Advanced Glycation End Product

Catechin has a good inhibitory effect on advanced glycation end product (AGE) formation in alcoholic media, which is generated by Maillard reaction is closely related to diabetes.

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