Supercritical CO2-Extracted Tomato Oleoresins Enhance Gap Junction Intercellular Communications and Recover from Mercury Chloride Inhibition in Keratinocytes

2010 ◽  
Vol 58 (8) ◽  
pp. 4769-4778 ◽  
Author(s):  
Antonella Leone ◽  
Roberto Zefferino ◽  
Cristiano Longo ◽  
Lucia Leo ◽  
Giuseppe Zacheo
Keyword(s):  
Gap Junction ◽  
Supercritical Co2 ◽  
Mercury Chloride ◽  
Intercellular Communications ◽  
Gap Junction Intercellular Communications

Resveratrol and X rays affect gap junction intercellular communications in human glioblastoma cells

2008 ◽  
Vol 47 (8) ◽  
pp. 587-598 ◽  
Author(s):  
Stefano Leone ◽  
Mario Fiore ◽  
M. Giuliana Lauro ◽  
Samanta Pino ◽  
Tommaso Cornetta ◽  
...  
Keyword(s):  
Gap Junction ◽  
X Rays ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Intercellular Communications ◽  
Gap Junction Intercellular Communications

scholarly journals Gap Junction Intercellular Communications Regulate NK Cell Activation and Modulate NK Cytotoxic Capacity

2013 ◽  
Vol 192 (3) ◽  
pp. 1313-1319 ◽  
Author(s):  
Andrés Tittarelli ◽  
Ariadna Mendoza-Naranjo ◽  
Marcela Farías ◽  
Israel Guerrero ◽  
Fumitaka Ihara ◽  
...  
Keyword(s):  
Gap Junction ◽  
Cell Activation ◽  
Nk Cell ◽  
Intercellular Communications ◽  
Gap Junction Intercellular Communications

Rat mast cells communicate with fibroblasts via gap junction intercellular communications

2007 ◽  
Vol 100 (5) ◽  
pp. 1170-1177 ◽  
Author(s):  
Stephen R. Au ◽  
Katherine Au ◽  
Gregory C. Saggers ◽  
Neel Karne ◽  
H. Paul Ehrlich
Keyword(s):  
Mast Cells ◽  
Gap Junction ◽  
Intercellular Communications ◽  
Gap Junction Intercellular Communications ◽  
Rat Mast Cells

scholarly journals Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Roberto Zefferino ◽  
Claudia Piccoli ◽  
Nunzia Ricciardi ◽  
Rosella Scrima ◽  
Nazzareno Capitanio
Keyword(s):  
Gap Junction ◽  
Genetic Alterations ◽  
Environmental Pollutant ◽  
Tumor Promoter ◽  
Screening Methods ◽  
Chemical Agent ◽  
Present Contribution ◽  
Dna Mutation ◽  
Mediated Effects ◽  
Intercellular Communications

A number of observations indicate that heavy metals are able to alter cellular metabolic pathways through induction of a prooxidative state. Nevertheless, the outcome of heavy metal-mediated effects in the development of human diseases is debated and needs further insights. Cancer is a well-established DNA mutation-linked disease; however, epigenetic events are perhaps more important and harmful than genetic alterations. Unfortunately, we do not have reliable screening methods to assess/validate the epigenetic (promoter) effects of a physical or a chemical agent. We propose a mechanism of action whereby mercury acts as a possible promoter carcinogen. In the present contribution, we resume our previous studies on mercury tested at concentrations comparable with its occurrence as environmental pollutant. It is shown that Hg(II) elicits a prooxidative state in keratinocytes linked to inhibition of gap junction-mediated intercellular communication and proinflammatory cytokine production. These combined effects may on one hand isolate cells from tissue-specific homeostasis promoting their proliferation and on the other hand tamper the immune system defense/surveillance checkmating the whole organism. Since Hg(II) is not a mutagenic/genotoxic compound directly affecting gene expression, in a broader sense, mercury might be an example of an epigenetic tumor promoter or, further expanding this concept, a “metagenetic” effector.

Subcytotoxic mercury chloride inhibits gap junction intercellular communication by a redox- and phosphorylation-mediated mechanism

2012 ◽  
Vol 52 (5) ◽  
pp. 916-927 ◽  
Author(s):  
Claudia Piccoli ◽  
Annamaria D'Aprile ◽  
Rosella Scrima ◽  
Luigi Ambrosi ◽  
Roberto Zefferino ◽  
...  
Keyword(s):  
Gap Junction ◽  
Intercellular Communication ◽  
Mercury Chloride ◽  
Gap Junction Intercellular Communication
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