Physiological Difference between Free and Triglyceride-type Conjugated Linoleic Acid on the Immune Function of C57BL/6N Mice

2004 ◽  
Vol 52 (11) ◽  
pp. 3644-3648 ◽  
Author(s):  
Masao Yamasaki ◽  
Takae Kitagawa ◽  
Hitomi Chujo ◽  
Nami Koyanagi ◽  
Eri Nishida ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Immune Function ◽  
Conjugated Linoleic Acid ◽  
Physiological Difference ◽  
Triglyceride Type

Modulation of immune function by conjugated linoleic acid in chickens

2007 ◽  
Vol 18 (3-4) ◽  
pp. 169-178 ◽  
Author(s):  
Xi He ◽  
Haijun Zhang ◽  
Xiaojun Yang ◽  
Shirui Zhang ◽  
Qiuzhong Dai ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Immune Function ◽  
Conjugated Linoleic Acid

scholarly journals The effects of conjugated linoleic acid on human health-related outcomes

2005 ◽  
Vol 64 (2) ◽  
pp. 171-182 ◽  
Author(s):  
Sabine Tricon ◽  
Graham C. Burdge ◽  
Christine M. Williams ◽  
Philip C. Calder ◽  
Parveen Yaqoob
Keyword(s):  
Body Composition ◽  
Linoleic Acid ◽  
Immune Function ◽  
Conjugated Linoleic Acid ◽  
Human Subjects ◽  
Blood Lipid ◽  
Immune Functions ◽  
Blood Lipid Profile ◽  
Specific Effects ◽  
Health Related

Conjugated linoleic acid (CLA) is a collective term for a mixture of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. CLA has received considerable attention as a result of animal experiments that report anti-carcinogenic, anti-atherogenic and anti-diabetic properties, and modulation of body composition and immune function. Several studies of CLA supplementation in human subjects have now been published, but in contrast to animal studies there has been marked variation between reports on the health-related outcomes. The consensus from seventeen published studies in human subjects is that CLA does not affect body weight or body composition. Some detrimental effects of thetrans-10,cis-12 CLA isomer have also been reported in terms of altered blood lipid composition and impaired insulin sensitivity. Finally, CLA has only limited effects on immune functions in man. However, there have been reports of some interesting isomer-specific effects of CLA on the blood lipid profile, but not on immune function. These isomer-specific effects need further investigation. Until more is known, CLA supplementation in man should be considered with caution.

scholarly journals Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men

2003 ◽  
Vol 57 (4) ◽  
pp. 595-603 ◽  
Author(s):  
R Albers ◽  
R P J van der Wielen ◽  
E J Brink ◽  
H F J Hendriks ◽  
V N Dorovska-Taran ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Immune Function ◽  
Conjugated Linoleic Acid ◽  
Healthy Men ◽  
Cla Isomers

scholarly journals The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers

2005 ◽  
Vol 59 (6) ◽  
pp. 742-750 ◽  
Author(s):  
A P Nugent ◽  
H M Roche ◽  
E J Noone ◽  
A Long ◽  
D K Kelleher ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Healthy Volunteers ◽  
Immune Function ◽  
Conjugated Linoleic Acid ◽  
Acid Supplementation

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

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