Virgin Olive Oil Normalizes the Altered Triacylglycerol Molecular Species Composition of Adipose Tissue in Spontaneously Hypertensive Rats

2004 ◽  
Vol 52 (13) ◽  
pp. 4227-4233 ◽  
Author(s):  
Javier S. Perona ◽  
Valentina Ruiz-Gutierrez
Keyword(s):  
Adipose Tissue ◽  
Species Composition ◽  
Olive Oil ◽  
Molecular Species ◽  
Spontaneously Hypertensive Rats ◽  
Virgin Olive Oil ◽  
Hypertensive Rats ◽  
Molecular Species Composition ◽  
Spontaneously Hypertensive ◽  
Triacylglycerol Molecular Species

scholarly journals Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1728 ◽  
Author(s):  
Alejandra Vazquez ◽  
Estefania Sanchez-Rodriguez ◽  
Félix Vargas ◽  
Sebastián Montoro-Molina ◽  
Miguel Romero ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Phenolic Compounds ◽  
Olive Oil ◽  
Bioactive Compounds ◽  
Spontaneously Hypertensive Rats ◽  
Virgin Olive Oil ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Cholesterol Levels ◽  
Group 1

Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), enriched in bioactive compounds from olive fruit and leaves, on blood pressure, endothelial function, oxidative and inflammatory status, and circulating cholesterol levels, in spontaneously hypertensive rats (SHR). Thirty SHR were randomly assigned to three groups: a control untreated SHR group, an SHR group (1 mL/rat/day) of a control olive oil (17.6 mg/kg of phenolic compounds), and an SHR group (1 mL/rat/day) of the enriched EVOO (750 mg/kg of phenolic compounds) for eight weeks. Ten Wistar Kyoto rats (WKY) were included as healthy controls. Long-term administration of the enriched EVOO decreased systolic blood pressure and cardiac hypertrophy, and improved the ex vivo aortic endothelial dysfunction measured in SHR. Moreover, enriched oil supplementation reduced the plasma levels of Angiotensin II and total cholesterol, and the urinary levels of endothelin-1 and oxidative stress biomarkers, while pro-inflammatory cytokines were unaffected. In conclusion, sustained treatment with EVOO, enriched in bioactive compounds from the olive fruit and leaves, may be an effective tool for reducing blood pressure and cholesterol levels alone or in combination with pharmacological anti-hypertensive treatment.

Influence of Extra Virgin Olive Oil on Blood Pressure and Kidney Angiotensinase Activities in Spontaneously Hypertensive Rats

Planta Medica ◽  
2014 ◽  
Vol 81 (08) ◽  
pp. 664-669 ◽  
Author(s):  
Ana Villarejo ◽  
Manuel Ramírez-Sánchez ◽  
Ana Segarra ◽  
Magdalena Martínez-Cañamero ◽  
Isabel Prieto
Keyword(s):  
Blood Pressure ◽  
Olive Oil ◽  
Spontaneously Hypertensive Rats ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Role of the antiglucocorticoid RU 486 in the prevention of steroid-induced hypertension

1992 ◽  
Vol 127 (3) ◽  
pp. 258-261 ◽  
Author(s):  
Justicia Opoku ◽  
Mohammed Kalimi
Keyword(s):  
Blood Pressure ◽  
Olive Oil ◽  
Water Intake ◽  
Urine Output ◽  
Spontaneously Hypertensive Rats ◽  
Experimental Models ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Ru 486

In the present study, we determined the effect of RU 486 on two experimental models of hypertension in the rat, deoxycorticosterone acetate (DOCA)-salt in nephrectomized rats and spontaneously hypertensive rats. Uni-nephrectomized saline-drinking male Sprague-Dawley rats were divided into three groups and each animal was given either 0.2ml olive oil (control), 1 mg DOCA, or 1 mg DOCA +10 mg RU 486 dissolved in 0.2 ml olive oil every third day for a period of three weeks. Within a week of steroid administration, there was a significant increase in the systolic blood pressure (SBP) in the DOCA-salt (157±3.8 mmHg) and DOCA+RU 486 (155±2.1 mmHg) treated rats over the control (116±2.6 mmHg) rats, which remained elevated throughout the experimental period. There was significant increase in the water intake and urine output in DOCA or DOCA+RU 486 treated rats as compared to the control untreated rats. In the experiment involving the spontaneously hypertensive rats, the rats were divided into three groups and each animal given 0.2 ml olive oil (control), 1 mg RU 486, or 5 mg RU 486 dissolved in 0.2 ml olive oil for six weeks. Instead of the expected decrease in the blood pressure, RU 486 significantly elevated blood pressure during the six weeks of drug administration. Water intake, urine output, and weights remained comparable in both groups. We conclude that RU 486 has no effect on the DOCA-salt model of hypertension but, surprisingly, elevates hypertension in the spontaneously hypertensive rats.

scholarly journals Perivascular Adipose Tissue and Mesenteric Vascular Function in Spontaneously Hypertensive Rats

2006 ◽  
Vol 26 (6) ◽  
pp. 1297-1302 ◽  
Author(s):  
Beatriz Gálvez ◽  
Javier de Castro ◽  
Diana Herold ◽  
Galyna Dubrovska ◽  
Silvia Arribas ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Vascular Function ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Perivascular Adipose Tissue ◽  
Spontaneously Hypertensive
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