Increased sensitivity of adipose tissue of spontaneously hypertensive rats to ACTH

1979 ◽  
Vol 88 (1) ◽  
pp. 696-699
Author(s):  
M. B. Reznikova ◽  
Yu. V. Postnov
Keyword(s):  
Adipose Tissue ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Increased Sensitivity

Decreased CGRP level with increased sensitivity to CGRP in the pial arteries of spontaneously hypertensive rats

Life Sciences ◽  
1997 ◽  
Vol 60 (10) ◽  
pp. 697-705 ◽  
Author(s):  
Ki Whan Hong ◽  
Sung Suk Yu ◽  
Yung Woo Shin ◽  
Chi Dae Kim ◽  
Byung Yong Rhim ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Pial Arteries ◽  
Spontaneously Hypertensive ◽  
Increased Sensitivity

scholarly journals Perivascular Adipose Tissue and Mesenteric Vascular Function in Spontaneously Hypertensive Rats

2006 ◽  
Vol 26 (6) ◽  
pp. 1297-1302 ◽  
Author(s):  
Beatriz Gálvez ◽  
Javier de Castro ◽  
Diana Herold ◽  
Galyna Dubrovska ◽  
Silvia Arribas ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Vascular Function ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Perivascular Adipose Tissue ◽  
Spontaneously Hypertensive

scholarly journals Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension

2021 ◽  
Vol 22 (21) ◽  
pp. 11812
Author(s):  
Atsunori Yamamoto ◽  
Kosuke Otani ◽  
Muneyoshi Okada ◽  
Hideyuki Yamawaki
Keyword(s):  
Adipose Tissue ◽  
Protein Expression ◽  
Western Blotting ◽  
Spontaneously Hypertensive Rats ◽  
Biologically Active ◽  
Systemic Hypertension ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Peripheral Protein ◽  
Wistar Kyoto

Adipocytokine chemerin is a biologically active molecule secreted from adipose tissue. Chemerin elicits a variety of functions via chemokine-like receptor 1 (CMKLR1). The cardiovascular center in brain that regulates blood pressure (BP) is involved in pathophysiology of systemic hypertension. Thus, we explored the roles of brain chemerin/CMKLR1 on regulation of BP in spontaneously hypertensive rats (SHR). For this aim, we examined effects of intracerebroventricular (i.c.v.) injection of CMKLR1 small interfering (si)RNA on both systemic BP as measured by tail cuff system and protein expression in paraventricular nucleus (PVN) of SHR as determined by Western blotting. We also examined both central and peripheral protein expression of chemerin by Western blotting. Systolic BP of SHR but not normotensive Wistar Kyoto rats (WKY) was decreased by CMKLR1 siRNA. The decrease of BP by CMKLR1 siRNA persisted for 3 days. Protein expression of CMKLR1 in PVN of SHR tended to be increased compared with WKY, which was suppressed by CMKLR1 siRNA. Protein expression of chemerin in brain, peripheral plasma, and adipose tissue was not different between WKY and SHR. In summary, we for the first time revealed that the increased protein expression of CMKLR1 in PVN is at least partly responsible for systemic hypertension in SHR.

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