Grape Seed Proanthocyanidins Prevent Plasma Postprandial Oxidative Stress in Humans

2002 ◽  
Vol 50 (26) ◽  
pp. 7720-7725 ◽  
Author(s):  
Fausta Natella ◽  
Federica Belelli ◽  
Vincenzo Gentili ◽  
Fulvio Ursini ◽  
Cristina Scaccini
Keyword(s):  
Oxidative Stress ◽  
Grape Seed ◽  
Grape Seed Proanthocyanidins

Grape seed proanthocyanidins prevent DOCA-salt hypertension-induced renal injury and its mechanisms in rats

2015 ◽  
Vol 6 (7) ◽  
pp. 2179-2186 ◽  
Author(s):  
Chao-zong Lan ◽  
Ling Ding ◽  
Yi-lin Su ◽  
Kun Guo ◽  
Li Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Dysfunction ◽  
Renal Injury ◽  
Grape Seed ◽  
Deoxycorticosterone Acetate ◽  
Grape Seed Proanthocyanidins ◽  
Acetate Salt ◽  
Salt Hypertension

Renal dysfunction is one of the major effects of DOCA (deoxycorticosterone acetate)-salt hypertension and there is an increasing amount of evidence that oxidative stress damages the function of the kidney.

Grape seed proanthocyanidins improves mitochondrial function and reduces oxidative stress through an increase in sirtuin 3 expression in EA.hy926 cells in high glucose condition

2020 ◽  
Vol 47 (5) ◽  
pp. 3319-3330 ◽  
Author(s):  
Aline Fagundes Cerbaro ◽  
Victoria Soldatelli Borges Rodrigues ◽  
Marina Rigotti ◽  
Catia Santos Branco ◽  
Giovana Rech ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Function ◽  
High Glucose ◽  
Grape Seed ◽  
Sirtuin 3 ◽  
Grape Seed Proanthocyanidins ◽  
High Glucose Condition ◽  
Ea.Hy926 Cells ◽  
Glucose Condition

scholarly journals The molecular and biochemical insight view of grape seed proanthocyanidins in ameliorating cadmium-induced testes-toxicity in rat model: implication of PI3K/Akt/Nrf-2 signaling

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Nazima Bashir ◽  
Kalist Shagirtha ◽  
Vaikundam Manoharan ◽  
Selvaraj Miltonprabu
Keyword(s):  
Oxidative Stress ◽  
Protective Action ◽  
Grape Seed ◽  
Histological Changes ◽  
Grape Seed Proanthocyanidins ◽  
Protein Expressions ◽  
Male Wistar Rats ◽  
And Oxidative Stress ◽  
Enos Protein ◽  
Significant Increment

Abstract The present study aims to evaluate the protective effect of grape seed proanthocyanidins (GSP) on cadmium (Cd)-induced testicular apoptosis, inflammation, and oxidative stress in rats. A total of 24 male Wistar rats were divided into four groups, namely control, GSP (100 mg/kg BW), Cd (5 mg/kg BW), and Cd+GSP. Cd-treated rat testes exhibited a significant increment in oxidative stress mediated inflammation and apoptosis. Pre-administration of GSP exhibit significant protection against the apoptotic and inflammatory damages elicited by Cd and uphold the intercellular antioxidant status in testes. Histological changes were studied and the immunohistochemical staining for caspase 3, HSP70, and eNOS protein expressions were also analyzed to justify the protective action of GSP. Furthermore, GSP prevented DNA damage, and enhanced the expression of antioxidant responsive elements Nrf2/HO-1 by PI3K/Akt-dependent pathway. Therefore, our results suggest that GSP acts as a multipotent antioxidant entity against Cd-induced oxidative testicular toxicity in rats.

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