Grape seed proanthocyanidins prevent DOCA-salt hypertension-induced renal injury and its mechanisms in rats

2015 ◽  
Vol 6 (7) ◽  
pp. 2179-2186 ◽  
Author(s):  
Chao-zong Lan ◽  
Ling Ding ◽  
Yi-lin Su ◽  
Kun Guo ◽  
Li Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Dysfunction ◽  
Renal Injury ◽  
Grape Seed ◽  
Deoxycorticosterone Acetate ◽  
Grape Seed Proanthocyanidins ◽  
Acetate Salt ◽  
Salt Hypertension

Renal dysfunction is one of the major effects of DOCA (deoxycorticosterone acetate)-salt hypertension and there is an increasing amount of evidence that oxidative stress damages the function of the kidney.

scholarly journals Role of angiotensin II type 1a receptor in renal injury induced by deoxycorticosterone acetate–salt hypertension

2016 ◽  
Vol 31 (1) ◽  
pp. 72-84 ◽  
Author(s):  
Mikako Hisamichi ◽  
Atsuko Kamijo‐Ikemori ◽  
Takeshi Sugaya ◽  
Daisuke Ichikawa ◽  
Takayuki Natsuki ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Renal Injury ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension

Grape seed proanthocyanidins ameliorates cadmium-induced renal injury and oxidative stress in experimental rats through the up-regulation of nuclear related factor 2 and antioxidant responsive elements

2015 ◽  
Vol 93 (3) ◽  
pp. 210-226 ◽  
Author(s):  
Bashir Nazima ◽  
Vaihundam Manoharan ◽  
Selvaraj Miltonprabu
Keyword(s):  
Oxidative Stress ◽  
Renal Injury ◽  
Caspase 3 ◽  
Grape Seed ◽  
Ionic Form ◽  
Related Factor ◽  
Enzymatic Antioxidants ◽  
Grape Seed Proanthocyanidins ◽  
Tnf Α ◽  
And Oxidative Stress

Cadmium (Cd) preferentially accumulates in the kidney, the major target for Cd-related toxicity. Cd-induced reactive oxygen species (ROS) have been considered crucial mediators for renal injury. The biologically significant ionic form of cadmium (Cd+) binds to many bio-molecules, and these interactions underlie the toxicity mechanisms of Cd. The present study was hypothesized to explore the protective effect of grape seed proanthocyanidins (GSP) on Cd-induced renal toxicity and to elucidate the potential mechanism. Male Wistar rats were treated with Cd as cadmium chloride (CdCl2, 5 mg·kg−1 bw, orally) and orally pre-administered with GSP (100 mg·kg−1 bw) 90 min before Cd intoxication for 4 weeks to evaluate renal damage of Cd and antioxidant potential of GSP. Serum renal function parameters (blood urea nitrogen and creatinine) levels in serum and urine, renal oxidative stress (lipid peroxidation, protein carbonylation, enzymatic, and non-enzymatic antioxidants), inflammatory (NF-κB p65, NO, TNF-α, IL-6), apoptotic (caspase-3, caspase-9, Bax, Bcl-2), membrane bound ATPases, and Nrf2 (HO-1, keap1, γ-GCS, and μ-GST) markers were evaluated in Cd-treated rats. Pretreatment with GSP revealed a significant improvement in renal oxidative stress markers in kidneys of Cd-treated rats. In addition, GSP treatment decreases the amount of iNOS, NF-κB, TNF-α, caspase-3, and Bax and increases the levels Bcl-2 protein expression. Similarly, mRNA and protein analyses substantiated that GSP treatment notably normalizes the renal expression of Nrf2/Keap1 and its downstream regulatory proteins in the Cd-treated rats. Histopathological and ultra-structural observations also demonstrated that GSP effectively protects the kidney from Cd-induced oxidative damage. These findings suggest that GSP ameliorates renal dysfunction and oxidative stress through the activation of Nrf2 pathway in Cd-intoxicated rats.

Kinin-Mediated Antihypertensive Effect of Captopril in Deoxycorticosterone Acetate–Salt Hypertension

Hypertension ◽  
1996 ◽  
Vol 27 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Ke Chen ◽  
Xuewei Zhang ◽  
Earl W. Dunham ◽  
Ben G. Zimmerman
Keyword(s):  
Antihypertensive Effect ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension

scholarly journals Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension

Hypertension ◽  
2013 ◽  
Vol 61 (3) ◽  
pp. 716-722 ◽  
Author(s):  
Aline M. Hilzendeger ◽  
Martin D. Cassell ◽  
Deborah R. Davis ◽  
Harald M. Stauss ◽  
Allyn L. Mark ◽  
...  
Keyword(s):  
Subfornical Organ ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension ◽  
Angiotensin Type

The Vascular Ornithine Decarboxylase/Polyamine System in Deoxycorticosterone Acetate-Salt Hypertension

1994 ◽  
pp. 279-288
Author(s):  
E. E. Soltis ◽  
P. S. Newman ◽  
M. E. Brown ◽  
J. L. Trowbridge ◽  
H. Guo ◽  
...  
Keyword(s):  
Ornithine Decarboxylase ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension

Chronic Caffeine Ingest ion Exacerbates 2-Kidney, 1-Clip Hypertension and Ameliorates Deoxycorticosterone Acetate-Salt Hypertension in Rats

Nephron ◽  
1993 ◽  
Vol 65 (4) ◽  
pp. 619-622 ◽  
Author(s):  
Ki Chul Choi ◽  
Jongeun Lee ◽  
Kyoung Hyup Moon ◽  
Kwang Ki Park ◽  
Soo Wan Kim ◽  
...  
Keyword(s):  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension ◽  
Chronic Caffeine

scholarly journals In vivo transfer of antisense oligonucleotide against urinary kininase blunts deoxycorticosterone acetate-salt hypertension in rats

2000 ◽  
Vol 131 (4) ◽  
pp. 820-826 ◽  
Author(s):  
Izumi Hayashi ◽  
Masataka Majima ◽  
Tomoe Fujita ◽  
Toshiaki Okumura ◽  
Yuji Kumagai ◽  
...  
Keyword(s):  
Antisense Oligonucleotide ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension
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