Activity optimization of pyridinyl N-oxide urea cytokinin mimics

1988 ◽  
Vol 36 (3) ◽  
pp. 626-633 ◽  
Author(s):  
Robert N. Henrie ◽  
Christine M. Green ◽  
Walter H. Yeager ◽  
Thomas F. Ball
Keyword(s):  
Activity Optimization

scholarly journals Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation

2020 ◽  
Vol 11 (9) ◽  
pp. 1023-1031
Author(s):  
Marion Poirier ◽  
Jonai Pujol-Giménez ◽  
Cristina Manatschal ◽  
Sven Bühlmann ◽  
Ahmed Embaby ◽  
...  
Keyword(s):  
Carrier Protein ◽  
Metal Chelation ◽  
Mechanistic Studies ◽  
Iron Transporter ◽  
Solute Carrier ◽  
Activity Optimization

Activity optimization of a pyrazolyl-pyrimidone against the iron transporter SLC11A2 (hDMT1) and mechanistic studies revealed that this class of inhibitors act by metal chelation.

scholarly journals First Synthesis of (−)-Altenuene-D3 Suitable as Internal Standard for Isotope Dilution Mass Spectrometry

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4563
Author(s):  
Michael A. Sebald ◽  
Julian Gebauer ◽  
Thomas Sommerfeld ◽  
Matthias Koch
Keyword(s):  
Mass Spectrometry ◽  
Antimicrobial Activity ◽  
Stable Isotope ◽  
Total Synthesis ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Internal Standard ◽  
Biological Properties ◽  
Mycotoxin Analysis ◽  
Activity Optimization

Metabolites from Alternaria fungi exhibit a variety of biological properties such as phytotoxic, cytotoxic, or antimicrobial activity. Optimization of a literature procedure culminated in an efficient total synthesis of (−)-altenuene as well as a stable isotope-labeled derivative suitable for implementation in a LC-MS/MS method for mycotoxin analysis.

scholarly journals Pomegranate seed oil nanoemulsions with selective antiglioma activity: optimization and evaluation of cytotoxicity, genotoxicity and oxidative effects on mononuclear cells

2016 ◽  
Vol 54 (12) ◽  
pp. 2968-2977 ◽  
Author(s):  
Luana Mota Ferreira ◽  
Mailine Gehrcke ◽  
Verônica Ferrari Cervi ◽  
Paula Eliete Rodrigues Bitencourt ◽  
Elita Ferreira da Silveira ◽  
...  
Keyword(s):  
Seed Oil ◽  
Mononuclear Cells ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed ◽  
Antiglioma Activity ◽  
Oxidative Effects ◽  
Activity Optimization

Financial Condition and Solvency of Russian Business in Modern Conditions

2019 ◽  
Vol 7 (2) ◽  
pp. 45-48
Author(s):  
И. Лысенко ◽  
I. Lysenko
Keyword(s):  
Economic Activity ◽  
Positive Impact ◽  
Successful Development ◽  
Economic Interests ◽  
Financial Position ◽  
Financial Condition ◽  
The Future ◽  
Statistical Indicators ◽  
National Business ◽  
Activity Optimization

Financial condition of the enterprise determines solvency and competitiveness of the enterprise, its potential in business cooperation, is the guarantor of effective realization of economic interests of all participants of economic activity. Optimization of the financial condition of the enterprise is one of the main conditions for its successful development in the future. The financial condition of the enterprise, its stability and stability depend on the results of its production, commercial and financial activities. If the production and financial plans are successfully implemented, it has a positive impact on the financial position of the enterprise. Conversely, as a result of the failure to fulfill the plan for the production and sale of products, there is an increase in its cost, a decrease in revenue and the amount of profit, and as a consequence, the deterioration of the financial condition of the enterprise and its solvency. The article analyzes the dynamics of statistical indicators characterizing the financial condition of Russian enterprises in the period 2010-2018. The branch structure of distribution of the profitable companies is described. Indicators of solvency of national business in the conditions of macroeconomic instability are investigated.

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