Ferritin in turkey muscle tissue: a source of catalytic iron ions for lipid peroxidation

1991 ◽  
Vol 39 (2) ◽  
pp. 247-249 ◽  
Author(s):  
Joseph Kanner ◽  
Linda Doll
Keyword(s):  
Lipid Peroxidation ◽  
Muscle Tissue ◽  
Iron Ions

scholarly journals Antioxidants, lysosomes and elements status during the life cycle of sea trout Salmo trutta m. trutta L.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Natalia Kurhaluk ◽  
Halyna Tkachenko
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Muscle Tissue ◽  
Salmo Trutta ◽  
Protein Carbonyl ◽  
Oxidative Modification ◽  
Oxidative Stress Biomarkers ◽  
Development Stages ◽  
Stress Biomarkers ◽  
Element Contents

AbstractThe aim of our study was to elucidate the effects of both development stages (parr, smolt, adult, spawner), and kelt as a survival form and sex (male, female) on the functional stability of the lysosomal complex, biomarkers of oxidative stress, and element contents in the muscle tissue of the sea trout (Salmo trutta m. trutta L.) sampled in the Pomerania region (northern Poland). We have evaluated the maximal activities of lysosomal enzymes (alanyl aminopeptidase, leucyl aminopeptidase, β-N-acetylglucosaminidase, and acid phosphatase), lipid peroxidation level, and protein carbonyl derivatives as indices of muscle tissue degradation. The relationship between lysosomal activity and oxidative stress biomarkers estimated by the lipid peroxidation level and protein carbonyl derivatives was also assessed, as well as the relationships between element levels and oxidative stress biomarkers. Trends of the main effects (i.e., the development stages and sex alone, the interaction of the sex and development stage simultaneously) on oxidative stress biomarkers, lysosomal functioning, and element contents in the muscle tissue were evaluated. The study has shown sex-related relationships between the pro- and antioxidant balance and the tissue type in the adult stage as well as modifications in the lysosomal functioning induced by long-term environmental stress associated with changing the habitats from freshwater to seawater and intense migrations. The highest level of toxic products generated in oxidative reactions and oxidative modification of proteins was noted in both the spawner stage and the kelt form. The holistic model of analysis of all parameters of antioxidant defense in all development stages and sex demonstrated the following dependencies for the level of lipid peroxidation, oxidative modification of proteins, lysosomal activities, and element contents: TBARS > OMP KD > OMP AD > TAC, AcP > NAG > LAP > AAP and Cu > Fe > Ca > Mn > Zn > Mg, respectively.

scholarly journals The stimulatory effects of asbestos on NADPH-dependent lipid peroxidation in rat liver microsomes

1987 ◽  
Vol 241 (2) ◽  
pp. 561-565 ◽  
Author(s):  
M Fontecave ◽  
D Mansuy ◽  
M Jaouen ◽  
H Pezerat
Keyword(s):  
Lipid Peroxidation ◽  
Rat Liver ◽  
Active Sites ◽  
Oxygen Radicals ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Iron Ions ◽  
Ferrous Ions ◽  
Solid Iron ◽  
Ferric Oxides

Lipid peroxidation in rat liver microsomes induced by asbestos fibres, crocidolite and chrysotile, is greatly increased in the presence of NADPH, leading to malondialdehyde levels comparable with those induced by CCl4, a very strong inducer of lipid peroxidation. This synergic effect only occurs during the first minutes and could be explained by an increase or a regeneration of the ferrous active sites of asbestos by NADPH, which in turn could rapidly be prevented by the adsorption of microsomal proteins on the surface of the fibres. It is not inhibited by superoxide dismutase, catalase and mannitol, indicating that oxygen radicals are not involved in the reaction. It is also not inhibited by desferrioxamine, indicating that it is not due to a release of free iron ions in solution from the fibres. Lipid peroxidation in NADPH-supplemented microsomes is also greatly increased upon addition of magnetite. This could be linked to the presence of ferrous ions in this solid iron oxide, since the ferric oxides haematite and goethite are completely inactive.

Lipid Peroxidation Dependent on Oxygen and Catalytic Free Iron Ions in Situ Storage Muscle Foods

1988 ◽  
pp. 301-306 ◽  
Author(s):  
Stella Harel ◽  
Joseph Shagalovich ◽  
Bella Hazan ◽  
Joseph Kanner
Keyword(s):  
Lipid Peroxidation ◽  
Iron Ions ◽  
Free Iron ◽  
Muscle Foods

scholarly journals Oxidative stress and antioxidant defence markers in muscle tissue of rainbow trout (Oncorhynchus mykiss) after vaccination against Yersinia ruckeri

2016 ◽  
Vol 60 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Halyna Tkachenko ◽  
Joanna Grudniewska ◽  
Agnieszka Pękala ◽  
Elżbieta Terech-Majewska
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Rainbow Trout ◽  
Oncorhynchus Mykiss ◽  
Muscle Tissue ◽  
Yersinia Ruckeri ◽  
Antioxidant Defence ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Significant Difference ◽  
Derivatives Of

AbstractIntroduction: The goal of this study was to assess the influence of vaccination against enteric redmouth disease on oxidative stress biomarkers and antioxidant defence in the muscle tissue of rainbow trout (Oncorhynchus mykiss Walbaum) vaccinated against Yersinia ruckeri in the first and second month after immunisation. Material and Methods: Healthy fish were vaccinated orally with inactivated whole cells of a virulent strain of Y. ruckeri. One and two months after immunisation the muscle samples were collected. Results: No significant difference was noted in lipid peroxidation level in either the first or second month after vaccination, while aldehydic and ketonic derivatives of oxidatively modified proteins (OMB) in the vaccinated group were significantly lower in the second month compared to those in the first month after vaccination (P < 0.05). The content of ketonic derivatives of OMB in muscles in the first month after immunisation was higher compared to untreated control. All these culminated in a depletion of glutathione peroxidase (GPx) activity and low level of total antioxidant capacity (TAC). Conclusion: Correlations between catalase activity and lipid peroxidation and TAC confirmed the pivotal role of catalase in antioxidant defence during immunisation. From a broader perspective, it is suggested that immunisation of fish with Yersinia vaccine is associated with induced free radical formation and oxidative stress. Free radicals would therefore be at least partially responsible for the induction of both humoral and cellular elements of the immunity and increased protective immunity against Y. ruckeri infection.

Lipid peroxidation of skeletal muscle: an in vitro study

1983 ◽  
Vol 3 (7) ◽  
pp. 609-619 ◽  
Author(s):  
M. J. Jackson ◽  
D. A. Jones ◽  
R. H. T. Edwards
Keyword(s):  
Skeletal Muscle ◽  
Lipid Peroxidation ◽  
Free Radical ◽  
Vitamin E ◽  
Hydroxyl Radicals ◽  
Muscle Tissue ◽  
In Vitro Study ◽  
Muscle Tissues ◽  
In Vitro Technique

The process of lipid peroxidation of skeletal muscle has been examined in vitro by monitoring the autoxidation of skeletal-muscle homogenates. Skeletal-muscle tissue has been shown to have considerable capacity for autoxidation and the process has been found to be initiated by a free-radical-mediated mechanism, critically dependent on the presence of free iron in the homogenate. The initiating radicals have not been firmly identified, but the results suggest that neither superoxide or hydroxyl radicals are involved. An in vitro technique for assessment of the antioxidant capacity of muscle tissue has also been developed which is capable of demonstrating differences between muscle tissues with differing vitamin E contents.

Esterases activities and lipid peroxidation levels in muscle tissue of the shanny Lipophrys pholis along several sites from the Portuguese Coast

2008 ◽  
Vol 56 (5) ◽  
pp. 999-1007 ◽  
Author(s):  
Montserrat Solé ◽  
Gemma Lobera ◽  
Daniela Lima ◽  
Maria Armanda Reis-Henriques ◽  
Miguel Machado Santos
Keyword(s):  
Lipid Peroxidation ◽  
Muscle Tissue ◽  
Portuguese Coast

Iron Release from the Active Site of Lipoxygenase

2000 ◽  
Vol 55 (7-8) ◽  
pp. 643-648 ◽  
Author(s):  
Claus Fuchs ◽  
Gerhard Spiteller
Keyword(s):  
Myocardial Infarction ◽  
Lipid Peroxidation ◽  
Active Site ◽  
Ferrous Iron ◽  
Oxygen Supply ◽  
Octadecadienoic Acid ◽  
Spectrophotometric Assay ◽  
Disodium Salt ◽  
Iron Ions ◽  
Iron Release

Abstract In the course of the lipoxygenase-catalyzed transformation of linoleic acid to 13S-hydroperoxy- 9Z,11E-octadecadienoic acid, iron ions are liberated. This iron release has been determined using a spectrophotometric assay based on the complexation of ferrous iron by 3-(2-pyridyl)-5,6-bis-(4-phenylsulfonic acid)-1,2,4-triazine disodium salt (ferrozine). Further comparative measurements demonstrated that iron release correlates to deficient oxygen supply. We speculate that release of iron ions is caused by modifications of histidine residues located at the active site of the enzyme. Liberation of iron ions may be responsible for increased generation of lipid peroxidation (LPO) products observed after a myocardial infarction since iron ions induce nonenzymic LPO processes.

Protective Effect of Egg Yolk Phosvitin Against Ultraviolet- Light-Induced Lipid Peroxidation in the Presence of Iron Ions

2005 ◽  
Vol 105 (1-3) ◽  
pp. 249-256 ◽  
Author(s):  
Shin-ichi Ishikawa ◽  
Shizuna Ohtsuki ◽  
Kentarou Tomita ◽  
Keizo Arihara ◽  
Makoto Itoh
Keyword(s):  
Lipid Peroxidation ◽  
Protective Effect ◽  
Ultraviolet Light ◽  
Egg Yolk ◽  
Iron Ions

scholarly journals The potential of using the bioluminescent system of Chaetopterus variopedatus to study ferroptosis in living organisms

2021 ◽  
Author(s):  
AS Shcheglov AS ◽  
AS Tsarkova
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Cell Death ◽  
Neurodegenerative Disorders ◽  
Living Cells ◽  
Laboratory Animals ◽  
Iron Ions ◽  
Chaetopterus Variopedatus ◽  
Organic Hydroperoxides ◽  
Living Organisms

Ferroptosis is a form of programmed cell death associated with iron-dependent lipid peroxidation. Novel ferroptosis inducers and suppressors could be instrumental in developing drugs against neurodegenerative disorders and cancer. Prior to embarking on a search for ferroptosis inducers/suppressors, this form of cell death must be studied in living cells and laboratory animals. In addition to two cofactors, luciferase (or photoprotein) of the parchment tubeworm Chaetopterus variopedatus requires the presence of iron ions and hydrogen peroxide or organic hydroperoxides to exert its activity. Therefore, the bioluminescence system of the parchment tubeworm can be used to study ferroptosis in living organisms.

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