Ascorbic Acid Inhibits Lipid Peroxidation but Enhances DNA Damage in Rat Liver Nuclei Incubated with Iron Ions

1997 ◽  
Vol 26 (6) ◽  
pp. 585-592 ◽  
Author(s):  
Miao-Lin Hu ◽  
Ming-Kuei Shih
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Ascorbic Acid ◽  
Rat Liver ◽  
Iron Ions ◽  
Rat Liver Nuclei ◽  
Liver Nuclei

scholarly journals Iron-induced DNA damage and synthesis in isolated rat liver nuclei

1982 ◽  
Vol 205 (2) ◽  
pp. 321-329 ◽  
Author(s):  
T K Shires
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Rat Liver ◽  
Reactive Oxygen ◽  
Direct Interaction ◽  
Isolated Rat Liver ◽  
Rat Liver Nuclei ◽  
Liver Nuclei ◽  
Isolated Rat ◽  
Dna Incorporation

Incubation of iron with isolated rat liver nuclei stimulated fragmentation of single-stranded DNA, incorporation of [3H]thymidine into DNA and the binding of 59Fe to DNA. FeCl2 was about twice as active as FeCl3. Lipid peroxidation took place in nuclei incubated with FeCl2, but not with FeCl3. Generation of reactive forms of oxygen was required for iron-mediated DNA damage, but evidence for direct interaction of reactive oxygen with DNA was not found. Apparent adducts of iron bound to DNA seemed to be formed by an enzymic mechanism.

NADPH-driven lipid peroxidation in rat liver nuclei and nuclear membranes

1980 ◽  
Vol 200 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Malcolm B. Baird ◽  
Linda S. Birnbaum ◽  
George T. Sfeir
Keyword(s):  
Lipid Peroxidation ◽  
Rat Liver ◽  
Rat Liver Nuclei ◽  
Nuclear Membranes ◽  
Liver Nuclei

Carcinogen induced DNA damage in isolated rat liver nuclei

1983 ◽  
Vol 18 (2) ◽  
pp. 163-167 ◽  
Author(s):  
Arthur M. Cohen ◽  
Hassan Prabhakar
Keyword(s):  
Dna Damage ◽  
Rat Liver ◽  
Isolated Rat Liver ◽  
Rat Liver Nuclei ◽  
Liver Nuclei ◽  
Isolated Rat
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