Solubility of Indinavir Sulfate in Different Solvents from (278.35 to 314.15) K

2009 ◽  
Vol 54 (7) ◽  
pp. 2106-2108 ◽  
Author(s):  
Guangyang Hou ◽  
Qiuxiang Yin ◽  
Meijing Zhang ◽  
Weiyi Su ◽  
Huilin Mao ◽  
...  
Keyword(s):  
Indinavir Sulfate

Optimization and statistical evaluation of dissolution tests for indinavir sulfate capsules

Il Farmaco ◽  
2004 ◽  
Vol 59 (11) ◽  
pp. 921-927 ◽  
Author(s):  
B. Carvalho-Silva ◽  
L.M. Moreira-Campos ◽  
E.A. Nunan ◽  
C.D. Vianna-Soares ◽  
B.L. Araujo-Alves ◽  
...  
Keyword(s):  
Statistical Evaluation ◽  
Dissolution Tests ◽  
Indinavir Sulfate

Single-Dose Pharmacokinetics of Indinavir and the Effect of Food

1998 ◽  
Vol 42 (2) ◽  
pp. 332-338 ◽  
Author(s):  
Kuang C. Yeh ◽  
Paul J. Deutsch ◽  
Heidi Haddix ◽  
Michael Hesney ◽  
Vicki Hoagland ◽  
...  
Keyword(s):  
Single Dose ◽  
Renal Clearance ◽  
Dose Range ◽  
Systemic Circulation ◽  
Tubular Secretion ◽  
Fed State ◽  
Fasted State ◽  
Indinavir Sulfate ◽  
Effect Of Food ◽  
Intrinsic Solubility

ABSTRACT Indinavir sulfate is a human immunodeficiency virus type 1 (HIV-1) protease inhibitor indicated for treatment of HIV infection and AIDS in adults. The purpose of this report is to summarize single-dose studies which characterized the pharmacokinetics of the drug and the effect of food in healthy volunteers. Indinavir concentrations in plasma and urine were obtained by high-pressure liquid chromatography and UV detection assay methods. The results indicate that indinavir was rapidly absorbed in the fasting state, with the time to the maximum concentration in plasma occurring at ∼0.8 h for all doses studied. Over the 40- to 1,000-mg dose range studied, concentrations in plasma and urinary excretion of unchanged drug increased greater than dose proportionally. The nonlinear pharmacokinetics were attributed to the dose-dependent oxidative metabolism of first-pass metabolism as well as to metabolism in the systemic circulation. Renal clearance slightly exceeded the glomerular filtration rate, suggesting a net tubular secretion component. At high concentrations in plasma, tubular secretion appeared to be lowered because there was a trend for a decreased renal clearance. Administration of 400 mg of indinavir sulfate following a high-fat breakfast resulted in a blunted and decreased absorption (areas under the concentration-time curves [AUCs], 6.86 μM·h in the fasted state versus 1.54 μM·h in the fed state; n = 10). However, two types of low-fat meals were found to have no significant effect on the absorption of 800 mg of indinavir sulfate (AUCs, 23.15 μM·h in the fasted state versus 22.71 and 21.36 μM·h, respectively, in the fed state; n = 11). Immediately following dosing, the concentrations of indinavir in urine often exceeded its intrinsic solubility. To reduce the risk of nephrolithiasis, it is recommended that indinavir sulfate be administered with water.

Desolvation behavior of indinavir sulfate ethanol and follow-up by terahertz spectroscopy

2019 ◽  
Vol 567 ◽  
pp. 118446 ◽  
Author(s):  
Masataka Ito ◽  
Reiko Tokuda ◽  
Hironori Suzuki ◽  
Tomoaki Sakamoto ◽  
Katsuhide Terada ◽  
...  
Keyword(s):  
Terahertz Spectroscopy ◽  
Indinavir Sulfate

ANURIA AND ACUTE RENAL FAILURE RESULTING FROM INDINAVIR SULFATE INDUCED NEPHROLITHIASIS

1998 ◽  
Vol 159 (2) ◽  
pp. 498-499 ◽  
Author(s):  
M. Witte ◽  
A. Tobon ◽  
J. Gruenenfelder ◽  
R. Goldfarb ◽  
M. Coburn
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Indinavir Sulfate

scholarly journals Validation and statistical analysis of two high performance liquid chromatography methods for the determination of indinavir sulfate raw material and capsules

Química Nova ◽  
2005 ◽  
Vol 28 (1) ◽  
pp. 50-53 ◽  
Author(s):  
Breno de Carvalho e Silva ◽  
Lígia Maria Moreira de Campos ◽  
Elzíria Aguiar Nunan ◽  
Cristina Duarte Vianna Soares ◽  
Gisele Rodrigues Silva ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Statistical Analysis ◽  
High Performance ◽  
Raw Material ◽  
Indinavir Sulfate

Indinavir Sulfate Renal Toxicity in a Pediatric Hemophiliac with HIV Infection

1997 ◽  
Vol 31 (10) ◽  
pp. 1146-1149 ◽  
Author(s):  
David P Ascher ◽  
Mitchell D Lucy
Keyword(s):  
Hiv Infection ◽  
Renal Toxicity ◽  
Nasal Congestion ◽  
Elevated Serum ◽  
Coagulation Factor ◽  
Low Grade ◽  
Cefpodoxime Proxetil ◽  
Case Summary ◽  
Indinavir Sulfate ◽  
Sterile Pyuria

OBJECTIVE: To report a case of renal toxicity associated with administration of indinavir sulfate in a pediatric hemophiliac with HIV infection. CASE SUMMARY: A 16-year-old white hemophiliac boy with HIV infection secondary to tainted coagulation factor VIII was treated with indinavir sulfate. The patient developed gross hematuria, proteinuria, pyuria, abdominal pain, increased bilirubin, an elevated serum creatinine (SCr) of 1.2 mg/dL (baseline 0.9–1.0), and symptoms of renal colic within 1 month of starting indinavir sulfate therapy. Approximately 2 months later the patient developed a low-grade fever with a further increase in SCr. He was prescribed a 10-day course of cefpodoxime proxetil for a possible urinary tract infection. One week later, the patient developed fever, chills, nausea, vomiting, decreased appetite, sterile pyuria, nasal congestion, and an elevated SCr of 1.3–1.7 mg/dL. Indinavir sulfate and cefpodoxime proxetil were discontinued and the patient was suspected of having tubulointerstitial nephritis secondary to indinavir sulfate. The patient's nephritis resolved and the SCr decreased to 1.1 mg/dL within 1 month of discontinuing indinavir sulfate. CONCLUSIONS: This case demonstrates the potential for renal toxicity with the use of indinavir sulfate in HIV-infected hemophiliacs.

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