Solvent Effects on pKaValues of Some Anticancer Agents in Acetonitrile–Water Binary Mixtures

2014 ◽  
Vol 59 (12) ◽  
pp. 4015-4020 ◽  
Author(s):  
Senem Sanli ◽  
Yuksel Altun ◽  
Gulsen Guven
Keyword(s):  
Binary Mixtures ◽  
Anticancer Agents ◽  
Solvent Effects

Solvent Effects on pKavalues of Some Substituted Sulfonamides in Acetonitrile−Water Binary Mixtures by the UV-Spectroscopy Method

2009 ◽  
Vol 54 (11) ◽  
pp. 3014-3021 ◽  
Author(s):  
Senem Şanli ◽  
Yüksel Altun ◽  
Nurullah Şanli ◽  
Güleren Alsancak ◽  
Jose L. Beltran
Keyword(s):  
Binary Mixtures ◽  
Solvent Effects ◽  
Uv Spectroscopy ◽  
Spectroscopy Method

Substituent and solvent effects on the reaction between 2,6-Di-t-butyl-α-(3,5-di-t-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)-p-tolyloxyl (galvinoxyl) and phenols

1978 ◽  
Vol 31 (6) ◽  
pp. 1201 ◽  
Author(s):  
N Nishimura ◽  
K Okahashi ◽  
T Yukutomi ◽  
A Fujiwara ◽  
S Kubo
Keyword(s):  
Carbon Tetrachloride ◽  
Binary Mixtures ◽  
Solvent Effects ◽  
Rate Constants ◽  
Isotope Effects ◽  
Mixed Solvents ◽  
Transition States ◽  
Activation Parameters ◽  
Substituted Phenols ◽  
Kinetic Behaviour

Rate constants and associated activation parameters for the reaction of galvinoxyl with substituted phenols were obtained in carbon tetrachloride and in cyclohexane-dioxan binary mixtures. Substantial isotope effects were observed for O-deuterated phenols. The rate constants are correlated with σ+ values. These findings are discussed by considering the polar contribution of substituents to the stabilization of the transition states. In the mixed solvents, the kinetic behaviour is well expressed by the equations which are based on the theory of Kondo and Tokura.

SULPHONIUM SALT SOLVOLYSIS: PART IV. SOLVENT EFFECTS

1963 ◽  
Vol 41 (7) ◽  
pp. 1679-1685 ◽  
Author(s):  
J. B. Hyne ◽  
J. H. Jensen
Keyword(s):  
Dielectric Constant ◽  
Ethylene Glycol ◽  
Binary Mixtures ◽  
Solvent Effects ◽  
Solvent Composition ◽  
Activation Process

The variation of rate of solvolysis of dimethyl-t-butyl sulphonium iodide as a function of solvent composition is reported for various binary mixtures of water with ethanol, N,N-dimethylformamide, N-methylformamide, dioxane, and ethylene glycol. The inadequacy of solvent bulk dielectric constant as a correlating parameter is demonstrated and solvent Y and Z parameters are compared in this respect. The importance of the specific microscopic role of the solvent in the activation process is demonstrated and a possible important nucleophilic role for the amides suggested. Deviations in dioxane and ethylene glycol systems are discussed.

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