Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

2018 ◽  
Vol 141 (2) ◽  
pp. 1126-1134 ◽  
Author(s):  
Jing Ning ◽  
Tao Liu ◽  
Peipei Dong ◽  
Wei Wang ◽  
Guangbo Ge ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Molecular Design ◽  
Design Strategy ◽  
Human Cytochrome

A highly selective ratiometric two-photon fluorescent probe for human cytochrome P450 1A1 and its application

2017 ◽  
Vol 32 (1) ◽  
pp. S37
Author(s):  
Ziru Dai ◽  
Guang-Bo Ge ◽  
Ling Yang ◽  
Lei Feng ◽  
Jing-Nan Cui ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Fluorescent Probe ◽  
Cytochrome P450 1A1 ◽  
Two Photon ◽  
Human Cytochrome

A Highly Selective Ratiometric Two-Photon Fluorescent Probe for Human Cytochrome P450 1A

2015 ◽  
Vol 137 (45) ◽  
pp. 14488-14495 ◽  
Author(s):  
Zi-Ru Dai ◽  
Guang-Bo Ge ◽  
Lei Feng ◽  
Jing Ning ◽  
Liang-Hai Hu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Fluorescent Probe ◽  
Two Photon ◽  
Human Cytochrome ◽  
Cytochrome P450 1A

scholarly journals A Two-in-One Janus NIR-II AIEgen with Balanced Absorption and Emission for Image-Guided Precision Surgery

2020 ◽  
Author(s):  
shunjie liu ◽  
yuanyuan li ◽  
Jianquan Zhang ◽  
Haoke Zhang ◽  
yong wang ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Near Infrared ◽  
Molecular Design ◽  
Parent Compound ◽  
Design Strategy ◽  
Molar Absorptivity ◽  
Absorption And Emission ◽  
Image Guided ◽  
High Fluorescence ◽  
Further Development

<p>Fluorescence imaging in the near-infrared II (NIR-II, 1000-1700 nm) region opens up new avenues for biological systems due to suppressed scattering and low autofluorescence at longer-wavelength photons. Nonetheless, the development of organic NIR-II fluorophores is still limited mainly due to the shortage of efficient molecular design strategy. Herein, we propose an approach of designing Janus NIR-II fluorophores by introducing electronic donors with distinct properties into one molecule. As a proof-of-concept, fluorescent dye 2TT-<i>m,o</i>C6B with both twisted and planar electronic donors displayed balanced absorption and emission which were absent in its parent compound. The key design strategy for Janus molecule is that it combines the merits of intense absorption from planar architecture and high fluorescence quantum yield from twisted motif. The resulting 2TT-<i>m,o</i>C6B nanoparticles exhibit a high molar absorptivity of 1.12 ⨯10<sup>4</sup> M<sup>-1</sup> cm<sup>-1 </sup>at 808 nm and a NIR-II quantum yield of 3.7%, displaying a typical aggregation-induced emission (AIE) attribute. The highly bright and stable 2TT-<i>m,o</i>C6B nanoparticles assured NIR-II image-guided cancer surgery to resect submillimeter tumor nodules. The present study may inspire further development of molecular design philosophy for highly bright NIR-II fluorophores for biomedical applications.</p>

Synthesis of a selective ratiometric fluorescent probe based on Naphthalimide and its application in human cytochrome P450 1A

Talanta ◽  
2018 ◽  
Vol 186 ◽  
pp. 413-420 ◽  
Author(s):  
Xiuxuan Zhang ◽  
Yan Zhou ◽  
Xiaofei Gu ◽  
Yu Cheng ◽  
Manxin Hong ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Fluorescent Probe ◽  
Human Cytochrome ◽  
Cytochrome P450 1A ◽  
Ratiometric Fluorescent Probe

scholarly journals A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging

2019 ◽  
Vol 10 (30) ◽  
pp. 7222-7227 ◽  
Author(s):  
Rongchen Wang ◽  
Jian Chen ◽  
Jie Gao ◽  
Ji-An Chen ◽  
Ge Xu ◽  
...  
Keyword(s):  
Real Time ◽  
Enzyme Activities ◽  
Near Infrared ◽  
Molecular Design ◽  
Cancer Imaging ◽  
Design Strategy ◽  
Real Time Monitoring ◽  
Stokes Shifts

A molecular design strategy is established to access diverse enzyme-activated probes that are excitable and emit in the NIR (I and II) region with favorable Stokes shifts, enabling targeted cancer imaging by real-time monitoring enzyme activities.

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