scholarly journals A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging

2019 ◽  
Vol 10 (30) ◽  
pp. 7222-7227 ◽  
Author(s):  
Rongchen Wang ◽  
Jian Chen ◽  
Jie Gao ◽  
Ji-An Chen ◽  
Ge Xu ◽  
...  
Keyword(s):  
Real Time ◽  
Enzyme Activities ◽  
Near Infrared ◽  
Molecular Design ◽  
Cancer Imaging ◽  
Design Strategy ◽  
Real Time Monitoring ◽  
Stokes Shifts

A molecular design strategy is established to access diverse enzyme-activated probes that are excitable and emit in the NIR (I and II) region with favorable Stokes shifts, enabling targeted cancer imaging by real-time monitoring enzyme activities.

scholarly journals Non-invasive, real-time reporting drug release in vitro and in vivo

2015 ◽  
Vol 51 (32) ◽  
pp. 6948-6951 ◽  
Author(s):  
Yanfeng Zhang ◽  
Qian Yin ◽  
Jonathan Yen ◽  
Joanne Li ◽  
Hanze Ying ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Reporting System ◽  
Real Time Monitoring ◽  
Near Infrared Fluorescence ◽  
Non Invasive ◽  
Fluorescence Dye

Anin vitroandin vivodrug-reporting system is developed for real-time monitoring of drug release via the analysis of the concurrently released near-infrared fluorescence dye.

Process modeling and control applied to real-time monitoring of distillation processes by near-infrared spectroscopy

2017 ◽  
Vol 985 ◽  
pp. 41-53 ◽  
Author(s):  
Rodrigo R. de Oliveira ◽  
Ricardo H.P. Pedroza ◽  
A.O. Sousa ◽  
Kássio M.G. Lima ◽  
Anna de Juan
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Near Infrared Spectroscopy ◽  
Process Modeling ◽  
Near Infrared ◽  
Real Time Monitoring ◽  
Modeling And Control ◽  
And Control

Ratiometric and light-up near-infrared fluorescent DCM-based probe for real-time monitoring endogenous tyrosinase activity

2019 ◽  
Vol 162 ◽  
pp. 802-807 ◽  
Author(s):  
Qiang Li ◽  
Chenxu Yan ◽  
Jie Zhang ◽  
Zhiqian Guo ◽  
Wei-Hong Zhu
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Tyrosinase Activity ◽  
Real Time Monitoring

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

scholarly journals Near infrared spectroscopic calibration models for real time monitoring of powder density

2016 ◽  
Vol 512 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Andrés D. Román-Ospino ◽  
Ravendra Singh ◽  
Marianthi Ierapetritou ◽  
Rohit Ramachandran ◽  
Rafael Méndez ◽  
...  
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Real Time Monitoring ◽  
Powder Density ◽  
Calibration Models ◽  
Infrared Spectroscopic

scholarly journals A New 3D Cultured Liver Chip and Real-Time Monitoring System Based on Microfluidic Technology

Micromachines ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1118
Author(s):  
Yao Zhang ◽  
Ning Yang ◽  
Liangliang Xie ◽  
Fangyu Shu ◽  
Qian Shi ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Monitoring System ◽  
Near Infrared Spectroscopy ◽  
In Vitro Model ◽  
Near Infrared ◽  
Real Time Monitoring ◽  
Microfluidic Technology ◽  
Vitro Model

In vitro models of the liver have a good simulation of the micro-liquid environment inside the human liver and the communication between cell tissues, which provides an important research tool for drug research and liver disease treatment. In this paper, we designed a 3D liver chip and real-time monitoring system based on microfluidic technology. The in vitro model of the liver on the chip was established by the three-dimensional microfluidic chip pipeline and the corresponding microwell array. Meanwhile, the culture medium is continuously injected on the chip, and the electrochemical impedance spectroscopy and near-infrared spectroscopy of the liver chip are recorded and analyzed from day one to day five. When the 3D cultured liver chip in vitro model reached a certain period and stabilized, paracetamol with varying gradients of concentration was applied to the cultured cells for drug resistance testing. The experimental results show that the liver chip and its monitoring system designed in this paper can maintain 100% cell viability of hepatocytes in vitro for a long time. Furthermore, it can meet the requirements of measurement technologies such as electrical impedance measurement and near-infrared spectroscopy in real-time, providing a stable culture platform for the further study of organ chips.

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