Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology

2018 ◽  
Vol 140 (44) ◽  
pp. 15114-15123 ◽  
Author(s):  
Srinivasa Rao Adusumalli ◽  
Dattatraya Gautam Rawale ◽  
Usha Singh ◽  
Prabhanshu Tripathi ◽  
Rajesh Paul ◽  
...  
Keyword(s):  
Chemical Technology ◽  
Single Site ◽  
Native Proteins ◽  
Selective Chemical ◽  
Site Selective

Chemoselective and Site‐Selective Lysine‐Directed Lysine Modification Enables Single‐Site Labeling of Native Proteins

2020 ◽  
Vol 59 (26) ◽  
pp. 10332-10336 ◽  
Author(s):  
Srinivasa Rao Adusumalli ◽  
Dattatraya Gautam Rawale ◽  
Kalyani Thakur ◽  
Landa Purushottam ◽  
Neelesh C. Reddy ◽  
...  
Keyword(s):  
Single Site ◽  
Native Proteins ◽  
Lysine Modification ◽  
Site Selective

Chemoselective and Site‐Selective Lysine‐Directed Lysine Modification Enables Single‐Site Labeling of Native Proteins

2020 ◽  
Vol 132 (26) ◽  
pp. 10418-10422 ◽  
Author(s):  
Srinivasa Rao Adusumalli ◽  
Dattatraya Gautam Rawale ◽  
Kalyani Thakur ◽  
Landa Purushottam ◽  
Neelesh C. Reddy ◽  
...  
Keyword(s):  
Single Site ◽  
Native Proteins ◽  
Lysine Modification ◽  
Site Selective

Chemoselective and site-selective peptide and native protein modification enabled by aldehyde auto-oxidation

2017 ◽  
Vol 53 (5) ◽  
pp. 959-962 ◽  
Author(s):  
Landa Purushottam ◽  
Srinivasa Rao Adusumalli ◽  
Maheshwerreddy Chilamari ◽  
Vishal Rai
Keyword(s):  
Protein Modification ◽  
Lysine Residue ◽  
Chemical Technology ◽  
Single Site ◽  
Native Protein ◽  
Protein Backbone ◽  
Precision Engineering ◽  
One Pot ◽  
Site Selective

Chemical technology delivers precision engineering of the native protein backbone. A lysine residue undergoes single-site formylation or acylation in a multi-step yet operationally simple one-pot process.

scholarly journals Rational Generation of Lasso Peptides Based on Biosynthetic Gene Mutations and Site-Selective Chemical Modifications

2021 ◽  
Author(s):  
Tan Liu ◽  
Xiaojie Ma ◽  
Jiahui Yu ◽  
Wensheng Yang ◽  
guiyang wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Gene Mutations ◽  
Proteolytic Degradation ◽  
Biosynthetic Gene ◽  
Chemical Modifications ◽  
Lasso Peptides ◽  
Selective Chemical ◽  
Site Selective

Lasso peptides are a unique family of natural products whose structures feature a specific threaded fold, which confers these peptides the resistance to thermal and proteolytic degradation. This stability gives...

scholarly journals A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

2019 ◽  
Vol 10 (3) ◽  
pp. 694-700 ◽  
Author(s):  
Stephen J. Walsh ◽  
Soleilmane Omarjee ◽  
Warren R. J. D. Galloway ◽  
Terence T.-L. Kwan ◽  
Hannah F. Sore ◽  
...  
Keyword(s):  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Native Proteins ◽  
Site Selective ◽  
Antibody Drug

Divinylpyrimidine (DVP) linkers enable access to highly stable and functional antibody–drug conjugates.

scholarly journals Site-Selective Chemical State Analysis for Magnetite Structure Using Powder Spectro-Diffractometry

1999 ◽  
Vol 38 (S1) ◽  
pp. 381 ◽  
Author(s):  
Yanan Xiao ◽  
Shinjiro Hayakawa ◽  
Yohichi Gohshi ◽  
Masaharu Oshima ◽  
Hiroki Okudera ◽  
...  
Keyword(s):  
Chemical State ◽  
Selective Chemical ◽  
Site Selective ◽  
State Analysis
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