scholarly journals Catalytic Kinetic Resolution of Disubstituted Piperidines by Enantioselective Acylation: Synthetic Utility and Mechanistic Insights

2015 ◽  
Vol 137 (35) ◽  
pp. 11491-11497 ◽  
Author(s):  
Benedikt Wanner ◽  
Imants Kreituss ◽  
Osvaldo Gutierrez ◽  
Marisa C. Kozlowski ◽  
Jeffrey W. Bode
Keyword(s):  
Kinetic Resolution ◽  
Synthetic Utility ◽  
Enantioselective Acylation

ChemInform Abstract: Catalytic Kinetic Resolution of Disubstituted Piperidines by Enantioselective Acylation: Synthetic Utility and Mechanistic Insights.

ChemInform ◽  
2016 ◽  
Vol 47 (5) ◽  
pp. no-no
Author(s):  
Benedikt Wanner ◽  
Imants Kreituss ◽  
Osvaldo Gutierrez ◽  
Marisa C. Kozlowski ◽  
Jeffrey W. Bode
Keyword(s):  
Kinetic Resolution ◽  
Synthetic Utility ◽  
Enantioselective Acylation

scholarly journals Progress on the Stereoselective Synthesis of Chiral Molecules Based on Metal-Catalyzed Dynamic Kinetic Resolution of Alcohols with Lipases

Symmetry ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1744
Author(s):  
Raffaella Ferraccioli
Keyword(s):  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Cascade Reactions ◽  
Allylic Alcohols ◽  
Chiral Molecules ◽  
Dynamic Kinetic Resolution ◽  
Multiple Bonds ◽  
One Pot ◽  
Synthetic Utility ◽  
Metal Catalyzed

Metal/lipase-combo catalyzed dynamic kinetic resolution (DKR) of racemic chiral alcohols is a general and practical process to obtain the corresponding enantiopure esters R with quantitative conversion. The use of known Ru-catalysts as well as newly developed homogeneous and heterogeneous metal catalysts (Fe, V) contributed to make the DKR process more sustainable and to expand the substrate scope of the reaction. In addition to classical substrates, challenging allylic alcohols, tertiary alcohols, C1-and C2-symmetric biaryl diols turned out to be competent substrates. Synthetic utility further emerged from the integration of this methodology into cascade reactions leading to linear/cyclic chiral molecules with high ee through the formation of multiple bonds, in a one-pot procedure.

Enzymatic kinetic resolution of racemic cyanohydrins via enantioselective acylation

Tetrahedron ◽  
2010 ◽  
Vol 66 (3) ◽  
pp. 624-630 ◽  
Author(s):  
Qing Xu ◽  
Yongli Xie ◽  
Xiaohong Geng ◽  
Peiran Chen
Keyword(s):  
Kinetic Resolution ◽  
Enzymatic Kinetic Resolution ◽  
Enantioselective Acylation

Highly Enantioselective Acylation of AcyclicMeso1,3-Diols through Synergistic Isothiourea-Catalyzed Desymmetrization/Chiroablative Kinetic Resolution

2015 ◽  
Vol 17 (9) ◽  
pp. 2118-2121 ◽  
Author(s):  
Jérémy Merad ◽  
Prashant Borkar ◽  
Tracy Bouyon Yenda ◽  
Christèle Roux ◽  
Jean-Marc Pons ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Enantioselective Acylation
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