Efficient kinetic resolution of (R,S)-1-trimethylsilylethanol via lipase-mediated enantioselective acylation in ionic liquids

Chirality ◽  
2006 ◽  
Vol 18 (10) ◽  
pp. 814-821 ◽  
Author(s):  
Wen-Yong Lou ◽  
Min-Hua Zong
Keyword(s):  
Ionic Liquids ◽  
Kinetic Resolution ◽  
Enantioselective Acylation

Long term continuous chemoenzymatic dynamic kinetic resolution of rac-1-phenylethanol using ionic liquids and supercritical carbon dioxide

2009 ◽  
Vol 11 (4) ◽  
pp. 538 ◽  
Author(s):  
Pedro Lozano ◽  
Teresa De Diego ◽  
Corina Mira ◽  
Kimberley Montague ◽  
Michel Vaultier ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Ionic Liquids ◽  
Supercritical Carbon Dioxide ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Supercritical Carbon

On the development of an integrated membrane process with ionic liquids for the kinetic resolution of rac-2-pentanol

2008 ◽  
Vol 314 (1-2) ◽  
pp. 238-246 ◽  
Author(s):  
F.J. Hernández-Fernández ◽  
A.P. de los Ríos ◽  
F. Tomás-Alonso ◽  
D. Gómez ◽  
G. Víllora
Keyword(s):  
Ionic Liquids ◽  
Kinetic Resolution ◽  
Membrane Process

scholarly journals Catalytic Kinetic Resolution of Disubstituted Piperidines by Enantioselective Acylation: Synthetic Utility and Mechanistic Insights

2015 ◽  
Vol 137 (35) ◽  
pp. 11491-11497 ◽  
Author(s):  
Benedikt Wanner ◽  
Imants Kreituss ◽  
Osvaldo Gutierrez ◽  
Marisa C. Kozlowski ◽  
Jeffrey W. Bode
Keyword(s):  
Kinetic Resolution ◽  
Synthetic Utility ◽  
Enantioselective Acylation

scholarly journals Kinetic resolution of Pent-4-ene-1,3-diol by Pd(II)-catalysed Oxycarbonylation in Ionic Liquids

2012 ◽  
Author(s):  
Giang Vo-Thanh ◽  
Jana Doháňošová ◽  
Tibor Gracza ◽  
Angelika Lásiková ◽  
Martial Toffano
Keyword(s):  
Ionic Liquids ◽  
Kinetic Resolution

Dynamic Kinetic Resolution of Sec-Alcohols in Ionic Liquids/Supercritical Carbon Dioxide Biphasic Systems

2009 ◽  
Vol 7 (1) ◽  
Author(s):  
Pedro Lozano ◽  
Teresa De Diego ◽  
Michel Vaultier ◽  
Jose L Iborra
Keyword(s):  
Carbon Dioxide ◽  
Ionic Liquids ◽  
Supercritical Carbon Dioxide ◽  
Kinetic Resolution ◽  
Immobilized Lipase ◽  
Enzymatic Catalysis ◽  
Chemical Properties ◽  
Dynamic Kinetic Resolution ◽  
Biphasic Systems ◽  
Supercritical Carbon

Supercritical fluids and ionic liquids are neoteric solvents that can be used as non-conventional reaction media for enzymatic catalysis under optimised conditions. These solvents exhibit many different physical and chemical properties, but have two cross-points: they are not-miscible and can be easily separated from substrates and products, and they can be reused. As supercritical carbon dioxide (scCO2) can dissolve in the ionic liquid (IL) phase (up to 0.7 mole fraction), a new concept of biphasic bioreactors for Fine Chemicals syntheses may be developed by using both enzyme and chemical catalysts "immobilized" into the IL phase, and substrates transported by the scCO2 phase. The system was tested for the continuous chemoenzymatic dynamic kinetic resolution (DKR) of rac-1-phenylethanol in IL/scCO2 by using simultaneously immobilized lipase (Novozym 435) and acid zeolites catalysts at 50°C and 100 bars, providing good yields (up 98.0 %) for R-phenylethyl propionate ester with excellent enantioselectivity (up to 97.3 %), and without any activity loss after 14 days of operation.

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