Development of Targetable Two-Photon Fluorescent Probes to Image Hypochlorous Acid in Mitochondria and Lysosome in Live Cell and Inflamed Mouse Model

2015 ◽  
Vol 137 (18) ◽  
pp. 5930-5938 ◽  
Author(s):  
Lin Yuan ◽  
Lu Wang ◽  
Bikram Keshari Agrawalla ◽  
Sung-Jin Park ◽  
Hai Zhu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fluorescent Probes ◽  
Hypochlorous Acid ◽  
Live Cell ◽  
Two Photon

scholarly journals Silafluorene as a promising core for cell-permeant, highly bright and two-photon excitable fluorescent probes for live-cell imaging

2021 ◽  
Vol 187 ◽  
pp. 109083
Author(s):  
Marie Auvray ◽  
Frédéric Bolze ◽  
Gilles Clavier ◽  
Florence Mahuteau-Betzer
Keyword(s):  
Fluorescent Probes ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Two Photon

scholarly journals Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice

2018 ◽  
Vol 9 (43) ◽  
pp. 8207-8212 ◽  
Author(s):  
Xinfu Zhang ◽  
Weiyu Zhao ◽  
Bin Li ◽  
Wenqing Li ◽  
Chengxiang Zhang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fluorescent Probe ◽  
Intravenous Administration ◽  
Fluorescent Probes ◽  
Lung Inflammation ◽  
Hypochlorous Acid ◽  
Ratiometric Fluorescent Probe

ClO1, a ratiometric fluorescent probe, effectively captured endogenous HClO in the lungs of a lipopolysaccharide (LPS)-induced lung inflammation mouse model after intravenous administration.

scholarly journals Fluorescent Probes for Live Cell Thiol Detection

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3575
Author(s):  
Shenggang Wang ◽  
Yue Huang ◽  
Xiangming Guan
Keyword(s):  
Fluorescent Probes ◽  
Biological System ◽  
High Sensitivity ◽  
Intracellular Distribution ◽  
Live Cell ◽  
Live Cells ◽  
High Demand ◽  
Non Invasive

Thiols play vital and irreplaceable roles in the biological system. Abnormality of thiol levels has been linked with various diseases and biological disorders. Thiols are known to distribute unevenly and change dynamically in the biological system. Methods that can determine thiols’ concentration and distribution in live cells are in high demand. In the last two decades, fluorescent probes have emerged as a powerful tool for achieving that goal for the simplicity, high sensitivity, and capability of visualizing the analytes in live cells in a non-invasive way. They also enable the determination of intracellular distribution and dynamitic movement of thiols in the intact native environments. This review focuses on some of the major strategies/mechanisms being used for detecting GSH, Cys/Hcy, and other thiols in live cells via fluorescent probes, and how they are applied at the cellular and subcellular levels. The sensing mechanisms (for GSH and Cys/Hcy) and bio-applications of the probes are illustrated followed by a summary of probes for selectively detecting cellular and subcellular thiols.

scholarly journals Polarity-active NIR probes with strong two-photon absorption and ultrahigh binding affinity of insulin amyloid fibrils

2021 ◽  
Author(s):  
Li Li ◽  
Zheng Lv ◽  
Zhongwei Man ◽  
Zhenzhen Xu ◽  
YuLing Wei ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Binding Affinity ◽  
Fluorescent Probes ◽  
Amyloid Fibrils ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Medical Diagnostic

Amyloid fibrils are associated with many neurodegenerative diseases. In-situ and in-vivo visualization of amyloid fibrils is important for medical diagnostic and requires fluorescent probes with both excitation and emission wavelengths in...

scholarly journals In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis

2012 ◽  
Vol 278 (1-2) ◽  
pp. 158-165 ◽  
Author(s):  
Tamás Kobezda ◽  
Sheida Ghassemi-Nejad ◽  
Tibor T. Glant ◽  
Katalin Mikecz
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
Mouse Model ◽  
Lymph Nodes ◽  
Cell Motility ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging ◽  
Draining Lymph Nodes

Instant Live-Cell Super-Resolution Imaging of Cellular Structures by Nanoinjection of Fluorescent Probes

Nano Letters ◽  
2015 ◽  
Vol 15 (2) ◽  
pp. 1374-1381 ◽  
Author(s):  
Simon Hennig ◽  
Sebastian van de Linde ◽  
Martina Lummer ◽  
Matthias Simonis ◽  
Thomas Huser ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Super Resolution ◽  
Live Cell ◽  
Cellular Structures ◽  
Resolution Imaging

NIR-region two-photon fluorescent probes for Fe3+/Cu2+ ions based on pyrimidine derivatives with different flexible chain

2016 ◽  
Vol 222 ◽  
pp. 574-578 ◽  
Author(s):  
Qiong Zhang ◽  
Xiaohe Tian ◽  
Hui Wang ◽  
Zhangjun Hu ◽  
Jieying Wu ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Pyrimidine Derivatives ◽  
Flexible Chain ◽  
Two Photon
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