scholarly journals Phenylboronic Acid Modification Augments the Lysosome Escape and Antitumor Efficacy of a Cylindrical Polymer Brush-Based Prodrug

2021 ◽  
Author(s):  
Ruonan Wang ◽  
Changfeng Yin ◽  
Changren Liu ◽  
Ying Sun ◽  
Panpan Xiao ◽  
...  
Keyword(s):  
Phenylboronic Acid ◽  
Polymer Brush ◽  
Antitumor Efficacy ◽  
Acid Modification

scholarly journals Phenylboronic acid modification augments the lysosome escape and antitumor efficacy of a cylindrical polymer brush-based prodrug

2021 ◽  
Author(s):  
Ruonan Wang ◽  
Changfeng Yin ◽  
Changren Liu ◽  
Ying Sun ◽  
Panpan Xiao ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Drug Loading ◽  
Phenylboronic Acid ◽  
Polymer Brush ◽  
Specific Interactions ◽  
Acid Modification ◽  
Tumor Penetration ◽  
Lysosomal Membrane Proteins ◽  
Shock Proteins ◽  
First Time

Abstract Timely lysosome escape is very important for nanomedicines to avoid premature degradation. Herein, we report an exciting finding that phenylboronic acid (PBA) modification can greatly facilitate the lysosome escape of cylindrical polymer brushes (CPBs), and further promote their exocytosis and transcellular transfer. This fundamental finding for the first time reveals that PBA groups improve the tumor penetration of nanomaterials via an active transcytosis mechanism. We speculate that the mechanism of the PBA-enhanced lysosome escape is associated with the specific interactions of the PBA group with the lysosomal membrane proteins and hot shock proteins. The featured advantage of the PBA modification over the known lysosome escape strategies is that it does not cause significant adverse effects on the properties of the CPBs. Furthermore, doxorubicin was conjugated to the PBA-modified CPBs with drug loading content larger than 20%. This CPBs-based prodrug could eradicate the tumors established in mice by multiple intravenous administration.

Peroxidase Activity of Cytochrome c Generated by Phenylboronic Acid Modification

1995 ◽  
Vol 24 (7) ◽  
pp. 529-530 ◽  
Author(s):  
Itaru Hamachi ◽  
Onari Kimura ◽  
Hiroshi Takeshita ◽  
Seiji Shinkai
Keyword(s):  
Cytochrome C ◽  
Peroxidase Activity ◽  
Phenylboronic Acid ◽  
Acid Modification

Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells

2013 ◽  
Vol 135 (20) ◽  
pp. 7603-7609 ◽  
Author(s):  
Hongliang Liu ◽  
Yingying Li ◽  
Kang Sun ◽  
Junbing Fan ◽  
Pengchao Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Phenylboronic Acid ◽  
Polymer Brush ◽  
Dual Responsive ◽  
Responsive Surfaces ◽  
Capture And Release

Sensing Capabilities of Colloidal Gold Monolayer Modified with a Phenylboronic Acid-Carrying Polymer Brush

2006 ◽  
Vol 7 (4) ◽  
pp. 1065-1071 ◽  
Author(s):  
Hiromi Kitano ◽  
Yasutaka Anraku ◽  
Hiroaki Shinohara
Keyword(s):  
Colloidal Gold ◽  
Phenylboronic Acid ◽  
Polymer Brush

Efficient enrichment of glycopeptides using phenylboronic acid polymer brush modified silica microspheres

2014 ◽  
Vol 2 (16) ◽  
pp. 2276-2281 ◽  
Author(s):  
Xiuling Li ◽  
Hongliang Liu ◽  
Guangyan Qing ◽  
Shutao Wang ◽  
Xinmiao Liang
Keyword(s):  
Synergistic Effect ◽  
High Selectivity ◽  
Phenylboronic Acid ◽  
Polymer Brush ◽  
Hydrogen Binding ◽  
Silica Microspheres ◽  
Modified Silica ◽  
Hydrophilic Nature

Phenylboronic acid (PBA) polymer brush modified silica demonstrated high selectivity for glycopeptides attributed to the synergistic effect of polyvalent interactions, hydrogen binding and hydrophilic nature provided by the polymer brush.

Cytotoxicity, NF-κB P65 inhibition, and in vivo antitumor efficacy of sesquiterpene lactones from Piptocoma rufescens

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
Y Ren ◽  
U Muñoz Acuña ◽  
DD Lantvit ◽  
F Jiménez ◽  
R García ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Antitumor Efficacy
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