A Tumor-Targeting Near-Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging-Guided Cancer Phototherapy

2021 ◽  
Author(s):  
Xiujie Zhao ◽  
Hongjie Zhao ◽  
Shuo Wang ◽  
Zhiwen Fan ◽  
Yan Ma ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Enhanced Imaging

scholarly journals Synthesis, Mesomorphism and the Optical Properties of Alkyl-deuterated Nematogenic 4-[(2,6-difluorophenyl)ethynyl]biphenyls

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4653
Author(s):  
Jakub Herman ◽  
Piotr Harmata ◽  
Michał Czerwiński ◽  
Olga Strzeżysz ◽  
Marta Pytlarczyk ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Mass Spectrometry ◽  
Differential Scanning Calorimetry ◽  
Optical Properties ◽  
Liquid Crystalline ◽  
Near Infrared ◽  
Synthesis And Characterization ◽  
Molecular Approach ◽  
Scanning Calorimetry

The synthesis and characterization of new deuterated liquid crystal (LC) compounds based on phenyl tolane core is described in this paper. The work presents an alternative molecular approach to the conventional LC design. Correlations between molecular structure and mesomorphic and optical properties for compounds which are alkyl-hydrogen terminated and alkyl-deuterium, have been drawn. The compounds are characterized by mass spectrometry (electron ionization) analysis and infrared spectroscopy. They show enantiotropic nematic behavior in a broad temperature range, confirmed by a polarizing thermomicroscopy and differential scanning calorimetry. Detailed synthetic procedures are attached. Synthesized compounds show a significantly reduced absorption in the near-infrared (NIR) and medium-wavelength infrared (MWIR) radiation range, and stand as promising components of medium to highly birefringent liquid crystalline mixtures.

scholarly journals Polyfluorenylacetylene for near-infrared laser protection: polymer synthesis, optical limiting mechanism and relationship between molecular structure and properties

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 53785-53796 ◽  
Author(s):  
Gang Zhao ◽  
Yan Feng ◽  
Shanyi Guang ◽  
Hongyao Xu ◽  
Naibo Lin ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Near Infrared ◽  
Optical Limiting ◽  
High Thermal Stability ◽  
Photon Absorption ◽  
Structure And Properties ◽  
Absorption Mechanism ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Good Solubility

The incorporation of styryl/stilbene–fluorene into polyacetylenes not only endowed the polymers with novel near-infrared optical limiting properties based on a two-photon absorption mechanism but good solubility and high thermal stability.

scholarly journals Unsymmetrical Heptamethine Dyes for NIR Dye-Sensitized Solar Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Thomas Geiger ◽  
Iuliia Schoger ◽  
Daniel Rentsch ◽  
Anna Christina Véron ◽  
Frédéric Oswald ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Solar Cells ◽  
Solar Cell ◽  
Near Infrared ◽  
Photophysical Properties ◽  
Dye Sensitized Solar Cells ◽  
Dye Sensitized ◽  
Sensitized Solar Cells ◽  
Nir Dye ◽  
Proof Of Principle

Seven unsymmetrical heptamethine dyes with carboxylic acid functionality were synthesized and characterized. These near-infrared dyes exhibit outstanding photophysical properties depending on their heterocyclic moieties and molecular structure. As proof of principle, the dyes were used as photosensitizers in dye-sensitized solar cells. Using the most promising dye, an overall conversion efficiency of 1.22% and an almost colorless solar cell were achieved.

Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

2018 ◽  
Vol 54 (83) ◽  
pp. 11777-11780 ◽  
Author(s):  
Ilona Zilkowski ◽  
Ioanna Theodorou ◽  
Krystyna Albrecht ◽  
Frederic Ducongé ◽  
Jürgen Groll
Keyword(s):  
Breast Tumor ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Side Chain ◽  
Human Breast ◽  
Human Breast Tumor ◽  
Tumor Xenografts ◽  
Network Composition ◽  
Tumor Accumulation

We studied the effect of subtle changes in side-chain chemistry and labelling with near infrared fluorophores of nanogels (NGs) prepared from thiolated poly(glycidol) on in vivo biodistribution in mice bearing human breast tumor xenografts. Side chain chemistry as well as labelling clearly influenced tumor targeting and overall biodistribution.

Facile in situ synthesis of ultrasmall near-infrared-emitting gold glyconanoparticles with enhanced cellular uptake and tumor targeting

Nanoscale ◽  
2019 ◽  
Vol 11 (35) ◽  
pp. 16336-16341 ◽  
Author(s):  
Yaping Wang ◽  
Shufeng Ma ◽  
Zhiyi Dai ◽  
Zhili Rong ◽  
Jinbin Liu
Keyword(s):  
Cellular Uptake ◽  
Tumor Targeting ◽  
Near Infrared ◽  
In Situ Synthesis ◽  
Targeting Efficiency ◽  
Gold Glyconanoparticles

Ultrasmall gold glyconanoparticles with enhanced tumor-targeting efficiency and efficient clearance through both renal and hepatobiliary pathways.

Shape tunable gallium nanorods mediated tumor enhanced ablation through near-infrared photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 2655-2667 ◽  
Author(s):  
Xuyang Sun ◽  
Mengmeng Sun ◽  
Miaomiao Liu ◽  
Bo Yuan ◽  
Weiping Gao ◽  
...  
Keyword(s):  
Liquid Metal ◽  
Metal Nanoparticles ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Photothermal Conversion

Shape tunable liquid metal nanoparticles were fabricated with characterization of biocompatibility, favorable photothermal conversion efficiency and tumor targeting capability for photothermal therapy.

scholarly journals Gold Nanorod Bioconjugates for Active Tumor Targeting and Photothermal Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hadiyah N. Green ◽  
Dmitry V. Martyshkin ◽  
Cynthia M. Rodenburg ◽  
Eben L. Rosenthal ◽  
Sergey B. Mirov
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Photothermal Effect ◽  
Specific Antibodies ◽  
Before And After ◽  
Egfr Antibody

The mastery of active tumor targeting is a great challenge in near infrared photothermal therapy (NIRPTT). To improve efficiency for targeted treatment of malignant tumors, we modify the technique of conjugating gold nanoparticles to tumor-specific antibodies. Polyethylene glycol-coated (PEGylated) gold nanorods (GNRs) were fabricated and conjugated to an anti-EGFR antibody. We characterized the conjugation efficiency of the GNRs by comparing the efficiency of antibody binding and the photothermal effect of the GNRs before and after conjugation. We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.

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