Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities

2021 ◽  
Author(s):  
Qingfeng Li ◽  
Victoria A. Maola ◽  
Nicholas Chim ◽  
Javeena Hussain ◽  
Adriana Lozoya-Colinas ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Threose Nucleic Acid

A parallel stranded G-quadruplex composed of threose nucleic acid (TNA)

Biopolymers ◽  
2016 ◽  
Vol 107 (3) ◽  
pp. e22999 ◽  
Author(s):  
Jen-yu Liao ◽  
Irina Anosova ◽  
Saikat Bala ◽  
Wade D. Van Horn ◽  
John C. Chaput
Keyword(s):  
Nucleic Acid ◽  
G Quadruplex ◽  
Threose Nucleic Acid

scholarly journals Activation of innate immune responses by a CpG oligonucleotide sequence composed entirely of threose nucleic acid

2018 ◽  
Author(s):  
Margaret J. Lange ◽  
Donald H. Burke ◽  
John C. Chaput
Keyword(s):  
Nucleic Acid ◽  
Immune Responses ◽  
B Cell ◽  
Cellular Proliferation ◽  
Darwinian Evolution ◽  
Nucleic Acid Therapeutics ◽  
Dna And Rna ◽  
Cpg Oligonucleotide ◽  
Threose Nucleic Acid ◽  
Oligonucleotide Sequence

AbstractRecent advances in synthetic biology have led to the development of nucleic acid polymers with backbone structures distinct from those found in nature, termed xeno-nucleic acids (XNAs). Several unique properties of XNAs make them attractive as nucleic acid therapeutics, most notably their high resistance to serum nucleases and ability to form Watson-Crick base-pairing with DNA and RNA. The ability of XNAs to induce immune responses has not been investigated. Threose nucleic acid (TNA), a type of XNA, is recalcitrant to nuclease digestion and capable of undergoing Darwinian evolution to produce high affinity aptamers; thus, TNA is an attractive candidate for diverse applications, including nucleic acid therapeutics. Here, we evaluated a TNA oligonucleotide derived from a CpG oligonucleotide sequence known to activate TLR9-dependent immune signaling in B cell lines. We observed a slight induction of relevant mRNA signals, robust B cell line activation, and negligible effects on cellular proliferation.

Selection of threose nucleic acid aptamers to block PD-1/PD-L1 interaction for cancer immunotherapy

2020 ◽  
Vol 56 (93) ◽  
pp. 14653-14656
Author(s):  
Xintong Li ◽  
Zhe Li ◽  
Hanyang Yu
Keyword(s):  
Nucleic Acid ◽  
Mouse Model ◽  
Cancer Immunotherapy ◽  
Tumour Growth ◽  
Xenograft Mouse Model ◽  
Nucleic Acid Aptamers ◽  
Threose Nucleic Acid ◽  
Selection Of

In vitro selected threose nucleic acid (TNA) aptamers blocked PD-1/PD-L1 interaction and significantly inhibited tumour growth in xenograft mouse model.

DNA Polymerase-Mediated Synthesis of Unbiased Threose Nucleic Acid (TNA) Polymers Requires 7-Deazaguanine To Suppress G:G Mispairing during TNA Transcription

2015 ◽  
Vol 137 (12) ◽  
pp. 4014-4017 ◽  
Author(s):  
Matthew R. Dunn ◽  
Andrew C. Larsen ◽  
Walter J. Zahurancik ◽  
Nour Eddine Fahmi ◽  
Madeline Meyers ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Polymerase ◽  
Threose Nucleic Acid

A Threose Nucleic Acid Enzyme with RNA Ligase Activity

2021 ◽  
Author(s):  
Yao Wang ◽  
Yueyao Wang ◽  
Dongfan Song ◽  
Xin Sun ◽  
Ze Zhang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Rna Ligase ◽  
Threose Nucleic Acid

An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination

2021 ◽  
Author(s):  
Yueyao Wang ◽  
Yao Wang ◽  
Dongfan Song ◽  
Xin Sun ◽  
Zhe Li ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Point Mutation ◽  
Single Point ◽  
Single Point Mutation ◽  
Threose Nucleic Acid
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