Chiral Metal Salts as Ligands for Catalytic Asymmetric Mannich Reactions with Simple Amides

2021 ◽  
Author(s):  
Yasuhiro Yamashita ◽  
Aika Noguchi ◽  
Seiya Fushimi ◽  
Miho Hatanaka ◽  
Shu̅ Kobayashi
Keyword(s):  
Metal Salts ◽  
Mannich Reactions ◽  
Catalytic Asymmetric

Catalytic Asymmetric Mannich Reactions of Sulfonylacetates

2009 ◽  
Vol 48 (31) ◽  
pp. 5694-5697 ◽  
Author(s):  
Carlo Cassani ◽  
Luca Bernardi ◽  
Francesco Fini ◽  
Alfredo Ricci
Keyword(s):  
Mannich Reactions ◽  
Catalytic Asymmetric

Asymmetric Synthesis of C1-Chiral THIQs with Imines in Isoquinoline Rings

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3337-3355
Author(s):  
Dan Li ◽  
Wei Gao ◽  
Xiaochao Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Biological Activities ◽  
Asymmetric Reactions ◽  
Structural Units ◽  
Mannich Reactions ◽  
Asymmetric Reaction ◽  
Azomethine Imines ◽  
Catalytic Asymmetric ◽  
Further Development ◽  
New Strategies

Tetrahydroisoquinoline (THIQ) scaffolds are important structural units that widely exist in a variety of natural alkaloids and synthetic analogues. Asymmetric synthesis of C1-chiral THIQ is of particular importance due to its significant pharmaceutical, agrochemical, and other biological activities, and the usually distinct bioactivities exhibited by the two enantiomers. In this review, we highlight the significant advances achieved in this field, present recent asymmetric synthesis with imines in isoquinoline rings ordered according to the sequence of various substrate types. New strategies could be inspired and more types of substrates need further development.1 Introduction2 Catalytic Asymmetric Reaction of Dihydroisoquinolines2.1 Asymmetric Reactions of 3,4-Dihydroisoquinolines2.2 Asymmetric Reactions of Dihydroisoquinolinium Salts2.3 Asymmetric Reactions of C,N-Cyclic N′-Acyl Azomethine Imines2.3.1 NED [3+2] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines2.3.2 IED [3+2] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines2.3.3 [3+3] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines2.3.4 [4+3] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines2.3.5 Asymmetric Addition Reactions to C,N-Cyclic N′-Acyl Azomethine Imines2.4 Asymmetric Reactions of C,N-Cyclic Nitrones3 Catalytic Asymmetric Mannich Reactions of Isoquinolines4 Conclusions and Perspectives

Catalytic Asymmetric Mannich Reactions of Sulfonylacetates

2009 ◽  
Vol 121 (31) ◽  
pp. 5804-5807 ◽  
Author(s):  
Carlo Cassani ◽  
Luca Bernardi ◽  
Francesco Fini ◽  
Alfredo Ricci
Keyword(s):  
Mannich Reactions ◽  
Catalytic Asymmetric
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