scholarly journals Catalytic Asymmetric Mannich Reactions with Fluorinated Aromatic Ketones: Efficient Access to Chiral β-Fluoroamines

2015 ◽  
Vol 55 (2) ◽  
pp. 781-784 ◽  
Author(s):  
Barry M. Trost ◽  
Tanguy Saget ◽  
Andreas Lerchen ◽  
Chao-I Joey Hung
Keyword(s):  
Mannich Reactions ◽  
Aromatic Ketones ◽  
Efficient Access ◽  
Catalytic Asymmetric

Catalytic Asymmetric Mannich Reactions with Fluorinated Aromatic Ketones: Efficient Access to Chiral β-Fluoroamines

2015 ◽  
Vol 128 (2) ◽  
pp. 791-794 ◽  
Author(s):  
Barry M. Trost ◽  
Tanguy Saget ◽  
Andreas Lerchen ◽  
Chao-I Joey Hung
Keyword(s):  
Mannich Reactions ◽  
Aromatic Ketones ◽  
Efficient Access ◽  
Catalytic Asymmetric

ChemInform Abstract: Direct Catalytic Asymmetric Reductive Amination of Simple Aromatic Ketones.

ChemInform ◽  
2014 ◽  
Vol 45 (4) ◽  
pp. no-no
Author(s):  
Mingxin Chang ◽  
Shaodong Liu ◽  
Kexuan Huang ◽  
Xumu Zhang
Keyword(s):  
Reductive Amination ◽  
Aromatic Ketones ◽  
Catalytic Asymmetric

Catalytic Asymmetric Mannich Reactions of Sulfonylacetates

2009 ◽  
Vol 48 (31) ◽  
pp. 5694-5697 ◽  
Author(s):  
Carlo Cassani ◽  
Luca Bernardi ◽  
Francesco Fini ◽  
Alfredo Ricci
Keyword(s):  
Mannich Reactions ◽  
Catalytic Asymmetric

Asymmetric Synthesis of C1-Chiral THIQs with Imines in Isoquinoline Rings

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3337-3355
Author(s):  
Dan Li ◽  
Wei Gao ◽  
Xiaochao Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Biological Activities ◽  
Asymmetric Reactions ◽  
Structural Units ◽  
Mannich Reactions ◽  
Asymmetric Reaction ◽  
Azomethine Imines ◽  
Catalytic Asymmetric ◽  
Further Development ◽  
New Strategies

Tetrahydroisoquinoline (THIQ) scaffolds are important structural units that widely exist in a variety of natural alkaloids and synthetic analogues. Asymmetric synthesis of C1-chiral THIQ is of particular importance due to its significant pharmaceutical, agrochemical, and other biological activities, and the usually distinct bioactivities exhibited by the two enantiomers. In this review, we highlight the significant advances achieved in this field, present recent asymmetric synthesis with imines in isoquinoline rings ordered according to the sequence of various substrate types. New strategies could be inspired and more types of substrates need further development.1 Introduction2 Catalytic Asymmetric Reaction of Dihydroisoquinolines2.1 Asymmetric Reactions of 3,4-Dihydroisoquinolines2.2 Asymmetric Reactions of Dihydroisoquinolinium Salts2.3 Asymmetric Reactions of C,N-Cyclic N′-Acyl Azomethine Imines2.3.1 NED [3+2] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines2.3.2 IED [3+2] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines2.3.3 [3+3] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines2.3.4 [4+3] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines2.3.5 Asymmetric Addition Reactions to C,N-Cyclic N′-Acyl Azomethine Imines2.4 Asymmetric Reactions of C,N-Cyclic Nitrones3 Catalytic Asymmetric Mannich Reactions of Isoquinolines4 Conclusions and Perspectives

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