Electrochemically Probing Dynamics of Ascorbate during Cytotoxic Edema in Living Rat Brain

2020 ◽  
Vol 142 (45) ◽  
pp. 19012-19016
Author(s):  
Jing Jin ◽  
Wenliang Ji ◽  
Lijuan Li ◽  
Gang Zhao ◽  
Wenjie Wu ◽  
...  
Keyword(s):  
Rat Brain ◽  
Cytotoxic Edema

scholarly journals Acute Ethanol-Induced Changes in Edema and Metabolite Concentrations in Rat Brain

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Huimin Liu ◽  
Wenbin Zheng ◽  
Gen Yan ◽  
Baoguo Liu ◽  
Lingmei Kong ◽  
...  
Keyword(s):  
Rat Brain ◽  
Frontal Lobes ◽  
Brain Regions ◽  
Ethanol Administration ◽  
Resonance Spectroscopy ◽  
Cytotoxic Edema ◽  
Acute Ethanol ◽  
Adc Values ◽  
Cerebral Metabolites

The aim of this study is to describe the acute effects of EtOH on brain edema and cerebral metabolites, using diffusion weight imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) at a 7.0T MR and to define changes in apparent diffusion coefficient (ADC) values and the concentration of metabolites in the rat brain after acute EtOH intoxication. ADC values in each ROI decreased significantly at 1 h and 3 h after ethanol administration. ADC values in frontal lobe were decreased significantly compared with other regions at 3 h. For EtOH/Cr+PCr and cerebral metabolites (Cho, Tau, and Glu) differing over time, no significant differences for Ins, NAA, and Cr were observed in frontal lobes. Regression analysis revealed a significant association between TSEtOH/Cr+PCrand TSCho, TSTau, TSGlu, and TSADC. The changes of ADC values in different brain regions reflect the process of the cytotoxic edema in vivo. The characterization of frontal lobes metabolites changes and the correlations between TSEtOH/Cr+PCrand TSCho, TSTau, and TSGluprovide a better understanding for the biological mechanisms in neurotoxic effects of EtOH on the brain. In addition, the correlations between TSEtOH/Cr+PCrand TSADCwill help us to understand development of the ethanol-induced brain cytotoxic edema.

The Effect of BAY K-8644 on Cytotoxic Edema Induced by Total Ischemia of Rat Brain

1994 ◽  
pp. 293-295
Author(s):  
M. Haida ◽  
Yukito Shinohara ◽  
M. Yamamoto ◽  
T. Nagayama ◽  
D. Kurita
Keyword(s):  
Rat Brain ◽  
Bay K 8644 ◽  
Cytotoxic Edema ◽  
Total Ischemia

cDNA cloning and expression of a gamma-aminobutyric acidA receptor epsilon-subunit in rat brain

2000 ◽  
Vol 12 (12) ◽  
pp. 4318-4330 ◽  
Author(s):  
Nathalie Moragues ◽  
Philippe Ciofi ◽  
Pierrette Lafon ◽  
Marie-Francoise Odessa ◽  
Gerard Tramu ◽  
...  
Keyword(s):  
Rat Brain ◽  
Cdna Cloning ◽  
Cloning And Expression ◽  
Epsilon Subunit

Antisense knockdown of the glial glutamate transporter GLT-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain

2001 ◽  
Vol 13 (1) ◽  
pp. 119-128 ◽  
Author(s):  
Vemuganti L. Raghavendra Rao ◽  
Aclan Dogan ◽  
Kellie K. Bowen ◽  
Kathryn G. Todd ◽  
Robert J. Dempsey
Keyword(s):  
Rat Brain ◽  
Neuronal Damage ◽  
Traumatic Injury ◽  
Glutamate Transporter ◽  
Glial Glutamate Transporter ◽  
Antisense Knockdown

Inhibition of Rat Brain Monoamine Oxidase Activities by Psoralen and Isopsoralen: Implications for the Treatment of Affective Disorders

2001 ◽  
Vol 88 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Ling Dong Kong ◽  
Ren Xiang Tan ◽  
Anthony Yiu Ho Woo ◽  
Christopher Hon Ki Cheng2Note
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Affective Disorders ◽  
Brain Monoamine
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