Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues

K. C. Nicolaou; Johannes Krieger; Ganesh M. Murhade; Parthasarathi Subramanian; Balu D. Dherange; Dionisios Vourloumis; Stefan Munneke; Baiwei Lin; Christine Gu; Hetal Sarvaiaya; Joseph Sandoval; Zhaomei Zhang; Monette Aujay; James W. Purcell; Julia Gavrilyuk

doi:10.1021/jacs.0c07094

Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues

Journal of the American Chemical Society ◽

10.1021/jacs.0c07094 ◽

2020 ◽

Vol 142 (36) ◽

pp. 15476-15487

Author(s):

K. C. Nicolaou ◽

Johannes Krieger ◽

Ganesh M. Murhade ◽

Parthasarathi Subramanian ◽

Balu D. Dherange ◽

...

Keyword(s):

Total Synthesis ◽

Biological Investigation ◽

Design Synthesis

Download Full-text

Design, synthesis, SAR study, and biological investigation of novel N-substituted benzamide enaminones as potential anticonvulsant agents

10.1021/scimeetings.0c07052 ◽

2020 ◽

Author(s):

Patrice Ayotunde ◽

Yayin Fang ◽

Isis J Amaye ◽

Miguel Martin

Keyword(s):

Biological Investigation ◽

Design Synthesis ◽

Anticonvulsant Agents ◽

Substituted Benzamide ◽

Sar Study

Download Full-text

Design, Synthesis, and Biological Investigation of Thailanstatin A and Spliceostatin D Analogues Containing Tetrahydropyran, Tetrahydrooxazine, and Fluorinated Structural Motifs

The Journal of Organic Chemistry ◽

10.1021/acs.joc.0c02643 ◽

2021 ◽

Vol 86 (3) ◽

pp. 2499-2521

Author(s):

K. C. Nicolaou ◽

Santhosh Reddy Rekula ◽

S. Mothish Kumar ◽

Ananda Rao Podilapu ◽

Ryan P. Matuszak ◽

...

Keyword(s):

Biological Investigation ◽

Structural Motifs ◽

Design Synthesis

Download Full-text

Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents

Journal of the American Chemical Society ◽

10.1021/jacs.8b06955 ◽

2018 ◽

Vol 140 (38) ◽

pp. 12120-12136 ◽

Cited By ~ 16

Author(s):

K. C. Nicolaou ◽

Ruofan Li ◽

Zhaoyong Lu ◽

Emmanuel N. Pitsinos ◽

Lawrence B. Alemany ◽

...

Keyword(s):

Total Synthesis ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Download Full-text

Correction to “Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues”

The Journal of Organic Chemistry ◽

10.1021/acs.joc.9b00159 ◽

2019 ◽

Vol 84 (4) ◽

pp. 2377-2378 ◽

Cited By ~ 1

Author(s):

K. C. Nicolaou ◽

Kiran Kumar Pulukuri ◽

Stephan Rigol ◽

Zisis Peitsinis ◽

Ruocheng Yu ◽

...

Keyword(s):

Total Synthesis ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Prostaglandin J2

Download Full-text

Total Synthesis and Biological Investigation of (−)‐Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific

Angewandte Chemie International Edition ◽

10.1002/anie.201802015 ◽

2018 ◽

Vol 57 (27) ◽

pp. 8293-8296 ◽

Cited By ~ 12

Author(s):

Johannes Krieger ◽

Toni Smeilus ◽

Marcel Kaiser ◽

Ean‐Jeong Seo ◽

Thomas Efferth ◽

...

Keyword(s):

Total Synthesis ◽

Antimalarial Activity ◽

Biological Investigation

Download Full-text

Total Synthesis and Biological Investigation of (−)-Promysalin

Journal of the American Chemical Society ◽

10.1021/jacs.5b04767 ◽

2015 ◽

Vol 137 (23) ◽

pp. 7314-7317 ◽

Cited By ~ 25

Author(s):

Andrew D. Steele ◽

Kyle W. Knouse ◽

Colleen E. Keohane ◽

William M. Wuest

Keyword(s):

Total Synthesis ◽

Biological Investigation

Download Full-text

ChemInform Abstract: Total Synthesis and Biological Investigation of (-)-Promysalin.

ChemInform ◽

10.1002/chin.201548199 ◽

2015 ◽

Vol 46 (48) ◽

pp. no-no

Author(s):

Andrew D. Steele ◽

Kyle W. Knouse ◽

Colleen E. Keohane ◽

William M. Wuest

Keyword(s):

Total Synthesis ◽

Biological Investigation

Download Full-text

Design, synthesis, characterisation, conformation and biological investigation of N-acyl r-2,c-6-bis (4-methoxyphenyl)-c-3,t-3-dimethylpiperidin-4-ones

Journal of Molecular Structure ◽

10.1016/j.molstruc.2017.05.036 ◽

2017 ◽

Vol 1144 ◽

pp. 502-513 ◽

Cited By ~ 4

Author(s):

V. Mohanraj ◽

S. Ponnuswamy

Keyword(s):

Biological Investigation ◽

Design Synthesis

Download Full-text

Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues

Journal of the American Chemical Society ◽

10.1021/jacs.7b08820 ◽

2017 ◽

Vol 139 (43) ◽

pp. 15467-15478 ◽

Cited By ~ 9

Author(s):

K. C. Nicolaou ◽

Pengxi Chen ◽

Shugao Zhu ◽

Quan Cai ◽

Rohan D. Erande ◽

...

Keyword(s):

Total Synthesis ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Download Full-text

Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2017.07.069 ◽

2017 ◽

Vol 27 (17) ◽

pp. 3974-3979 ◽

Cited By ~ 49

Author(s):

Harbinder Singh ◽

Jatinder V. Singh ◽

Manish K. Gupta ◽

Ajit K. Saxena ◽

Sahil Sharma ◽

...

Keyword(s):

Docking Studies ◽

Biological Investigation ◽

Design Synthesis ◽

Molecular Hybrids

Download Full-text