scholarly journals Steric-Free Bioorthogonal Labeling of Acetylation Substrates Based on a Fluorine–Thiol Displacement Reaction

2021 ◽  
Vol 143 (3) ◽  
pp. 1341-1347
Author(s):  
Zhigang Lyu ◽  
Yue Zhao ◽  
Zakey Yusuf Buuh ◽  
Nicole Gorman ◽  
Aaron R. Goldman ◽  
...  
Keyword(s):  
Displacement Reaction ◽  
Bioorthogonal Labeling

scholarly journals Steric-Free Bioorthogonal Labeling of Acetylation Substrates Based on a Fluorine-Thiol Displacement Reaction (FTDR)

2020 ◽  
Author(s):  
Zhigang Lyu ◽  
Yue Zhao ◽  
Zakey Yusuf Buuh ◽  
Nicole Gorman ◽  
Aaron R. Goldman ◽  
...  
Keyword(s):  
Functional Annotation ◽  
Live Cells ◽  
Displacement Reaction ◽  
Bioorthogonal Reaction ◽  
Post Translational Modifications ◽  
Amide Bonds ◽  
Bioorthogonal Labeling ◽  
Substrate Proteins

ABSTRACTWe have developed a novel bioorthogonal reaction that can selectively displace fluorine substitutions alpha to amide bonds. This fluorine-thiol displacement reaction (FTDR) allows for fluorinated cofactors or precursors to be utilized as chemical reporters; hijacking acetyltransferase mediated acetylation both in vitro and in live cells, which cannot be achieved with azide- or al- kyne- based chemical reporters. The fluoroacetamide labels can be further converted to biotin or fluorophore tags using FTDR, enabling the general detection and imaging of acetyl substrates. This strategy may lead to a steric-free labeling platform for substrate proteins, expanding our chemical toolbox for functional annotation of post-translational modifications (PTMs) in a systematic manner.

scholarly journals Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics

2017 ◽  
Vol 56 (31) ◽  
pp. 8992-8997 ◽  
Author(s):  
David R. Spiciarich ◽  
Rosalie Nolley ◽  
Sophia L. Maund ◽  
Sean C. Purcell ◽  
Jason Herschel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tissue Slice ◽  
Human Prostate ◽  
Cancer Tissue ◽  
Human Prostate Cancer ◽  
Bioorthogonal Labeling ◽  
Prostate Cancer Tissue

Introducing SiC/C dual-interface on porous silicon anode by a conventional exothermic displacement reaction for improved cycle performance

2021 ◽  
Vol 508 ◽  
pp. 230326
Author(s):  
Wenyang Zhou ◽  
Qinghuang Lian ◽  
Xiaokai Huang ◽  
Weiqiang Ding ◽  
Chunhai Jiang ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Silicon Anode ◽  
Cycle Performance ◽  
Displacement Reaction ◽  
Dual Interface

THE ACTION OF SODIUM IODIDE ON O-p-TOLUENE-SULPHONYL-1,4;3,6-DIANHYDRIDES OF D-MANNITOL, D-GLUCITOL, AND L-IDITOL

1959 ◽  
Vol 37 (6) ◽  
pp. 1048-1052 ◽  
Author(s):  
M. Jackson ◽  
L. D. Hayward
Keyword(s):  
Acetic Anhydride ◽  
Sodium Iodide ◽  
Crystalline Material ◽  
Displacement Reaction

In the displacement reaction with sodium iodide in acetic anhydride solution the rates of reaction of four isohexide tosyl esters were compared to that of an O-acetyl-O-tosylisosorbide recently described. The tosyloxy group in the latter compound was replaced rapidly and was therefore in the 5-endo-position, the compound being correctly named 2-O-acetyl-5-O-p-toluenesulphonyl-1,4;3,6-dianhydro-D-glucitol. The product of the reaction was isolated as a crystalline material, and was identified as 2-O-acetyl-5-deoxy-5-iodo-1,4;3,6-dianhydro-L-iditol.

Atomic layer-by-layer construction of Pd on nanoporous gold via underpotential deposition and displacement reaction

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19409-19417 ◽  
Author(s):  
Xuejiao Yan ◽  
Haiyan Xiong ◽  
Qingguo Bai ◽  
Jan Frenzel ◽  
Conghui Si ◽  
...  
Keyword(s):  
Atomic Layer ◽  
Underpotential Deposition ◽  
Nanoporous Gold ◽  
Layer By Layer ◽  
Displacement Reaction ◽  
Galvanic Displacement

Ultrathin Pd films with one to five atomic layers were decorated on nanoporous gold by underpotential deposition and galvanic displacement.

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