Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

1998 ◽  
Vol 120 (37) ◽  
pp. 9718-9719 ◽  
Author(s):  
Patrick H. Toy ◽  
Martin Newcomb ◽  
Minor J. Coon ◽  
Alfin D. N. Vaz
Keyword(s):  
Catalyzed Reactions ◽  
Cytochrome P 450

Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat

1983 ◽  
Vol 54 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Aalt Bast ◽  
E. Maria Savenije-Chapel ◽  
Frans A. A. van Kemenade ◽  
Lambertus W. C. Scheefhals ◽  
Jan Noordhoek
Keyword(s):  
Multiple Administration ◽  
Catalyzed Reactions ◽  
Cytochrome P 450

Cytochrome P-450 Catalyzed Reactions In Brain

1990 ◽  
pp. 133-146 ◽  
Author(s):  
Prahlad K. Seth ◽  
Alok Dhawan ◽  
Devendra Parmar ◽  
Mukul Das
Keyword(s):  
Catalyzed Reactions ◽  
Cytochrome P 450

Inhibition of Microsomal Lipid Peroxidation and Cytochrome P-450-Catalyzed Reactions by Nitrofuran Compounds

1991 ◽  
Vol 14 (5-6) ◽  
pp. 419-431 ◽  
Author(s):  
M. Dubin ◽  
S. H. Fernandez Villamil ◽  
M. Paulino De Blumenfeld ◽  
A. O. M. Stoppani
Keyword(s):  
Lipid Peroxidation ◽  
Microsomal Lipid Peroxidation ◽  
Catalyzed Reactions ◽  
Cytochrome P 450

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

Sign in / Sign up

Export Citation Format

Share Document