Asymmetric Total Synthesis of Callystatin A:  Asymmetric Aldol Additions with Titanium Enolates of Acyloxazolidinethiones

1998 ◽  
Vol 120 (35) ◽  
pp. 9084-9085 ◽  
Author(s):  
Michael T. Crimmins ◽  
Bryan W. King
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis ◽  
Asymmetric Aldol ◽  
Aldol Additions ◽  
Callystatin A ◽  
Titanium Enolates

Asymmetric Total Synthesis of (-)-Callystatin A and (-)-20-epi-Callystatin A Employing Chemical and Biological Methods.

ChemInform ◽  
2003 ◽  
Vol 34 (3) ◽  
Author(s):  
Dieter Enders ◽  
Jose L. Vicario ◽  
Andreas Job ◽  
Michael Wolberg ◽  
Michael Mueller
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis ◽  
Callystatin A ◽  
Biological Methods

Recent results toward the stereoselective synthesis of biologically active natural products

2007 ◽  
Vol 79 (2) ◽  
pp. 163-172 ◽  
Author(s):  
Luiz C. Dias ◽  
Luciana G. de Oliveira ◽  
Paulo R. R. Meira
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Cell Cultures ◽  
Stereoselective Synthesis ◽  
Animal Cell ◽  
Biologically Active ◽  
Asymmetric Total Synthesis ◽  
Callystatin A ◽  
Animal Cell Cultures ◽  
Active Natural

This paper describes the convergent and stereocontrolled asymmetric total synthesis of (+)-crocacins C and D, potent inhibitors of animal cell cultures and several yeasts and fungi, and (-)-callystatin A, a potent antitumor polyketide.

ChemInform Abstract: Asymmetric Total Synthesis of (-)-Callystatin A Employing the SAMP/RAMP Hydrazone Alkylation Methodology.

ChemInform ◽  
2010 ◽  
Vol 33 (36) ◽  
pp. no-no
Author(s):  
Jose L. Vicario ◽  
Andreas Job ◽  
Michael Wolberg ◽  
Michael Mueller ◽  
Dieter Enders
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis ◽  
Callystatin A

scholarly journals Stereoselective Synthesis of Oxazolidin-2-ones via an Asymmetric Aldol/Curtius Reaction: Concise Total Synthesis of (−)-Cytoxazone

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 597
Author(s):  
Hosam Choi ◽  
Hanho Jang ◽  
Joohee Choi ◽  
Kiyoun Lee
Keyword(s):  
Drug Discovery ◽  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Building Blocks ◽  
Ring Closure ◽  
Asymmetric Total Synthesis ◽  
Asymmetric Aldol ◽  
Curtius Reaction ◽  
Early Phases ◽  
Intramolecular Ring

Herein, we are reporting an efficient approach toward the synthesis of 4,5-disubstituted oxazolidin-2-one scaffolds. The developed approach is based on a combination of an asymmetric aldol and a modified Curtius protocol, which uses an effective intramolecular ring closure to rapidly access a range of oxazolidin-2-one building blocks. This strategy also permits a straightforward and concise asymmetric total synthesis of (−)-cytoxazone. Consisting of three steps, this is one of the shortest syntheses reported to date. Ultimately, this convenient platform would provide a promising method for the early phases of drug discovery.

Asymmetric Total Synthesis of (−)-Callystatin A Employing the SAMP/RAMP Hydrazone Alkylation Methodology

2002 ◽  
Vol 4 (6) ◽  
pp. 1023-1026 ◽  
Author(s):  
Jose L. Vicario ◽  
Andreas Job ◽  
Michael Wolberg ◽  
Michael Müller ◽  
Dieter Enders
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis ◽  
Callystatin A
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