A New Mechanism for the First Carbon−Carbon Bond Formation in the MTG Process:  A Theoretical Study

1998 ◽  
Vol 120 (32) ◽  
pp. 8222-8229 ◽  
Author(s):  
Nobuo Tajima ◽  
Takao Tsuneda ◽  
Fuminori Toyama ◽  
Kimihiko Hirao
Keyword(s):  
Theoretical Study ◽  
Bond Formation ◽  
Carbon Bond ◽  
Carbon Carbon Bond

Theoretical Study on the Mechanism of Robinson's Synthesis of Tropinone

2003 ◽  
Vol 2003 (9) ◽  
pp. 580-583 ◽  
Author(s):  
Nityagopal Mondal ◽  
Sannyasi Charan Mandal ◽  
Gourab Kanti Das ◽  
Sarbananda Mukherjee
Keyword(s):  
Ab Initio ◽  
Mannich Reaction ◽  
Theoretical Study ◽  
Bond Formation ◽  
Quantum Mechanical Calculation ◽  
Quantum Mechanical ◽  
Carbon Bond ◽  
Mechanical Calculation ◽  
Carbon Carbon Bond ◽  
Water Elimination

Ab initio quantum mechanical calculation reveals that the first Mannich reaction in Robinson's tropinone synthesis involves both carbon–carbon bond formation and water elimination, which is followed by tautomerisation and a second Mannich reaction to form the protonated tropinone.

A theoretical study of carbon–carbon bond formation by a Michael-type addition

2012 ◽  
Vol 10 (29) ◽  
pp. 5598 ◽  
Author(s):  
Katarzyna Świderek ◽  
Anna Pabis ◽  
Vicent Moliner
Keyword(s):  
Theoretical Study ◽  
Bond Formation ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Michael Type Addition

Carbon Dioxide-Mediated C(sp2)–H Arylation of Primary and Secondary Benzylamines

2018 ◽  
Author(s):  
Mohit Kapoor ◽  
Pratibha Chand-Thakuri ◽  
Michael Young
Keyword(s):  
Carbon Dioxide ◽  
Transition Metal ◽  
Bond Activation ◽  
Bond Formation ◽  
Carbon Bond ◽  
Chelate Effect ◽  
Free Amine ◽  
Carbon Carbon Bond ◽  
New Strategy ◽  
Metal Catalyzed

Carbon-carbon bond formation by transition metal-catalyzed C–H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of <i>ortho</i>-arylbenzylamines, however, effective <i>ortho</i>-C–C bond formation from C–H bond activation of free primary and secondary benzylamines using Pd<sup>II</sup> remains an outstanding challenge. Presented herein is a new strategy for constructing <i>ortho</i>-arylated primary and secondary benzylamines mediated by carbon dioxide (CO<sub>2</sub>). The use of CO<sub>2</sub> is critical to allowing this transformation to proceed under milder conditions than previously reported, and that are necessary to furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, a chelate effect is demonstrated to facilitate selective monoarylation.

Modern Organic Synthesis in the Laboratory

2008 ◽  
Author(s):  
Jie Jack Li ◽  
Chris Limberakis ◽  
Derek A. Pflum
Keyword(s):  
Organic Chemistry ◽  
Graduate Students ◽  
Organic Synthesis ◽  
Functional Group ◽  
Bond Formation ◽  
Reaction Conditions ◽  
Carbon Bond ◽  
Oxidation Reduction ◽  
Carbon Carbon Bond ◽  
Daunting Task

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

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