Rhodium-Catalyzed Coupling of 2-Silylphenylboronic Acids with Alkynes Leading to Benzosiloles: Catalytic Cleavage of the Carbon−Silicon Bond in Trialkylsilyl Groups

2009 ◽  
Vol 131 (22) ◽  
pp. 7506-7507 ◽  
Author(s):  
Mamoru Tobisu ◽  
Masahiro Onoe ◽  
Yusuke Kita ◽  
Naoto Chatani
Keyword(s):  
Catalytic Cleavage

Efficient Ni Based Catalysts for Hydrotreatment of Lignin Dimer Model Compounds to Cycloalkanes/Cycloalkanols

2021 ◽  
Author(s):  
Changzhou Chen ◽  
Dichao Wu ◽  
Peng Liu ◽  
Haihong Xia ◽  
Minghao Zhou ◽  
...  
Keyword(s):  
Noble Metal ◽  
Low Cost ◽  
Great Success ◽  
Model Compounds ◽  
Efficient Catalyst ◽  
Dimer Model ◽  
Catalytic Cleavage

Noble-metal catalytic cleavage of the ether bonds in lignin to obtain aromatic chemicals had achieved great success, and development of a low-cost and efficient catalyst was crucial. Herein, NixLay/CNT was...

Efficient catalytic cleavage of RNA by lanthanide(III) macrocyclic complexes: toward synthetic nucleases for in vivo applications

1992 ◽  
Vol 114 (5) ◽  
pp. 1903-1905 ◽  
Author(s):  
Janet R. Morrow ◽  
Lisa A. Buttrey ◽  
Valerie M. Shelton ◽  
Kristin A. Berback
Keyword(s):  
Macrocyclic Complexes ◽  
Synthetic Nucleases ◽  
Catalytic Cleavage

scholarly journals Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates

2019 ◽  
Vol 47 (10) ◽  
pp. 1156-1163 ◽  
Author(s):  
Donglu Zhang ◽  
Aimee Fourie-O’Donohue ◽  
Peter S. Dragovich ◽  
Thomas H. Pillow ◽  
Jack D. Sadowsky ◽  
...  
Keyword(s):  
Small Molecules ◽  
Disulfide Bonds ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Catalytic Cleavage ◽  
Antibody Drug

Heteroatom-participated lignin cleavage to functionalized aromatics

2020 ◽  
Vol 49 (12) ◽  
pp. 3748-3763 ◽  
Author(s):  
Hongji Li ◽  
Anon Bunrit ◽  
Ning Li ◽  
Feng Wang
Keyword(s):  
Catalytic Cleavage

Heteroatom-containing reagents triggered the catalytic cleavage of lignin linkages and functionalization of products simultaneously.

scholarly journals Structure-function analysis of microRNA 3′-end trimming by Nibbler

2020 ◽  
Vol 117 (48) ◽  
pp. 30370-30379
Author(s):  
Wei Xie ◽  
Ivica Sowemimo ◽  
Rippei Hayashi ◽  
Juncheng Wang ◽  
Thomas R. Burkard ◽  
...  
Keyword(s):  
Rna Binding ◽  
Function Analysis ◽  
Principal Role ◽  
Functional Studies ◽  
Surface Patches ◽  
Activity Modeling ◽  
Binding Surface ◽  
Catalytic Cleavage ◽  
Cleavage Motif

Nibbler (Nbr) is a 3′-to-5′ exoribonuclease whose catalytic 3′-end trimming activity impacts microRNA (miRNA) and PIWI-interacting RNA (piRNA) biogenesis. Here, we report on structural and functional studies to decipher the contributions of Nbr’s N-terminal domain (NTD) and exonucleolytic domain (EXO) in miRNA 3′-end trimming. We have solved the crystal structures of the NTD core and EXO domains of Nbr, both in the apo-state. The NTD-core domain ofAedes aegyptiNbr adopts a HEAT-like repeat scaffold with basic patches constituting an RNA-binding surface exhibiting a preference for binding double-strand RNA (dsRNA) over single-strand RNA (ssRNA). Structure-guided functional assays inDrosophilaS2 cells confirmed a principal role of the NTD in exonucleolytic miRNA trimming, which depends on basic surface patches. Gain-of-function experiments revealed a potential role of the NTD in recruiting Nbr to Argonaute-bound small RNA substrates. The EXO domain ofA. aegyptiandDrosophila melanogasterNbr adopt a mixed α/β-scaffold with a deep pocket lined by a DEDDy catalytic cleavage motif. We demonstrate that Nbr’s EXO domain exhibits Mn2+-dependent ssRNA-specific 3′-to-5′ exoribonuclease activity. Modeling of a 3′ terminal Uridine into the catalytic pocket of Nbr EXO indicates that 2′-O-methylation of the 3′-U would result in a steric clash with a tryptophan side chain, suggesting that 2′-O-methylation protects small RNAs from Nbr-mediated trimming. Overall, our data establish that Nbr requires its NTD as a substrate recruitment platform to execute exonucleolytic miRNA maturation, catalyzed by the ribonuclease EXO domain.

Catalytic Cleavage of the Thioethers1

1955 ◽  
Vol 77 (2) ◽  
pp. 501-501 ◽  
Author(s):  
Francis Binkley
Keyword(s):  
Catalytic Cleavage

ChemInform Abstract: Titanium Silicate Molecular Sieve (TS-1) Induced Catalytic Cleavage of Tosylhydrazones.

ChemInform ◽  
2010 ◽  
Vol 25 (9) ◽  
pp. no-no
Author(s):  
P. KUMAR ◽  
V. R. HEGDE ◽  
B. PANDEY ◽  
T. RAVINDRANATHAN
Keyword(s):  
Molecular Sieve ◽  
Titanium Silicate ◽  
Catalytic Cleavage
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