scholarly journals Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography

2013 ◽  
Vol 135 (8) ◽  
pp. 3173-3185 ◽  
Author(s):  
Michal Avital-Shmilovici ◽  
Kalyaneswar Mandal ◽  
Zachary P. Gates ◽  
Nelson B. Phillips ◽  
Michael A. Weiss ◽  
...  
Keyword(s):  
High Resolution ◽  
Chemical Synthesis ◽  
Protein Crystallography ◽  
X Ray

scholarly journals Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography

2010 ◽  
Vol 19 (10) ◽  
pp. 1840-1849 ◽  
Author(s):  
James R. Banigan ◽  
Kalyaneswar Mandal ◽  
Michael R. Sawaya ◽  
Vilasak Thammavongsa ◽  
Antoni P. A. Hendrickx ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Snake Venom ◽  
Protein Crystallography ◽  
Venom Protein ◽  
X Ray

Triosmium Clusters on a Support: Determination of Structure by X-ray Absorption Spectroscopy and High-Resolution Microscopy

2010 ◽  
Vol 17 (3) ◽  
pp. 1000-1008 ◽  
Author(s):  
Shareghe Mehraeen ◽  
Apoorva Kulkarni ◽  
Miaofang Chi ◽  
Bryan W. Reed ◽  
Norihiko L. Okamoto ◽  
...  
Keyword(s):  
High Resolution ◽  
Absorption Spectroscopy ◽  
Triosmium Clusters ◽  
X Ray ◽  
X Ray Absorption ◽  
High Resolution Microscopy

scholarly journals 3P-094 High resolution and precise X-ray crystal structure determination of Cyctochrome c Oxidase(The 46th Annual Meeting of the Biophysical Society of Japan)

2008 ◽  
Vol 48 (supplement) ◽  
pp. S142
Author(s):  
Michihiro Suga ◽  
Kyoko Ito-Shinzawa ◽  
Hiroshi Aoyama ◽  
Kazumasa Muramoto ◽  
Eiki Yamashita ◽  
...  
Keyword(s):  
Crystal Structure ◽  
High Resolution ◽  
Annual Meeting ◽  
Structure Determination ◽  
Crystal Structure Determination ◽  
X Ray ◽  
Biophysical Society

scholarly journals High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP–oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution

IUCrJ ◽  
2016 ◽  
Vol 3 (2) ◽  
pp. 115-126 ◽  
Author(s):  
E. I. Howard ◽  
B. Guillot ◽  
M. P. Blakeley ◽  
M. Haertlein ◽  
M. Moulin ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Fatty Acid ◽  
High Resolution ◽  
Density Distribution ◽  
Electron Density ◽  
Electron Density Distribution ◽  
Room Temperature ◽  
Water Molecules ◽  
X Ray

Crystal diffraction data of heart fatty acid binding protein (H-FABP) in complex with oleic acid were measured at room temperature with high-resolution X-ray and neutron protein crystallography (0.98 and 1.90 Å resolution, respectively). These data provided very detailed information about the cluster of water molecules and the bound oleic acid in the H-FABP large internal cavity. The jointly refined X-ray/neutron structure of H-FABP was complemented by a transferred multipolar electron-density distribution using the parameters of the ELMAMII library. The resulting electron density allowed a precise determination of the electrostatic potential in the fatty acid (FA) binding pocket. Bader's quantum theory of atoms in molecules was then used to study interactions involving the internal water molecules, the FA and the protein. This approach showed H...H contacts of the FA with highly conserved hydrophobic residues known to play a role in the stabilization of long-chain FAs in the binding cavity. The determination of water hydrogen (deuterium) positions allowed the analysis of the orientation and electrostatic properties of the water molecules in the very ordered cluster. As a result, a significant alignment of the permanent dipoles of the water molecules with the protein electrostatic field was observed. This can be related to the dielectric properties of hydration layers around proteins, where the shielding of electrostatic interactions depends directly on the rotational degrees of freedom of the water molecules in the interface.

High‐Resolution X‐Ray Powder Diffraction Structure Determination of C60F48

2006 ◽  
Vol 14 (2-3) ◽  
pp. 279-285 ◽  
Author(s):  
R. J. Papoular ◽  
H. Allouchi ◽  
A. V. Dzyabchenko ◽  
V. A. Davydov ◽  
A. V. Rakhmanina ◽  
...  
Keyword(s):  
High Resolution ◽  
Powder Diffraction ◽  
Structure Determination ◽  
X Ray ◽  
Diffraction Structure

Determination of Particle Size of a Dispersed Phase by Small-Angle X-ray Scattering

1989 ◽  
Vol 171 ◽  
Author(s):  
Frank C. Wilson
Keyword(s):  
Particle Size ◽  
High Resolution ◽  
Spherical Particles ◽  
Dispersed Phase ◽  
X Ray ◽  
X Ray Scattering ◽  
Resultant Data ◽  
Log Normal ◽  
Log Normal Distribution

ABSTRACTA method for determining particle diameters up to ca 500 rnm is described. X-ray data are obtained with an ultra-high resolution Bonse-Hart diffractometer and subsequently desmeared. The resultant data, viewed as the invariant argument h l(h), are interpreted as arising from a log-normal distribution of independent spherical particles. The distribution is characterized by its median value and breadth.

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