Combinatorially Inducible RNA Interference Triggered by Chemically Modified Oligonucleotides

2011 ◽  
Vol 133 (8) ◽  
pp. 2783-2788 ◽  
Author(s):  
Deepak Kumar ◽  
Sang Hoon Kim ◽  
Yohei Yokobayashi
Keyword(s):  
Rna Interference ◽  
Modified Oligonucleotides ◽  
Chemically Modified

scholarly journals Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 628
Author(s):  
Dagmara Baraniak ◽  
Jerzy Boryski
Keyword(s):  
Nucleic Acids ◽  
State Of The Art ◽  
Modified Oligonucleotides ◽  
Synthetic Genes ◽  
Chemically Modified ◽  
Amide Linkage ◽  
Dna And Rna ◽  
Modified Dna ◽  
Modified Nucleic Acids ◽  
Non Coding Rnas

This review covers studies which exploit triazole-modified nucleic acids in the range of chemistry and biology to medicine. The 1,2,3-triazole unit, which is obtained via click chemistry approach, shows valuable and unique properties. For example, it does not occur in nature, constitutes an additional pharmacophore with attractive properties being resistant to hydrolysis and other reactions at physiological pH, exhibits biological activity (i.e., antibacterial, antitumor, and antiviral), and can be considered as a rigid mimetic of amide linkage. Herein, it is presented a whole area of useful artificial compounds, from the clickable monomers and dimers to modified oligonucleotides, in the field of nucleic acids sciences. Such modifications of internucleotide linkages are designed to increase the hybridization binding affinity toward native DNA or RNA, to enhance resistance to nucleases, and to improve ability to penetrate cell membranes. The insertion of an artificial backbone is used for understanding effects of chemically modified oligonucleotides, and their potential usefulness in therapeutic applications. We describe the state-of-the-art knowledge on their implications for synthetic genes and other large modified DNA and RNA constructs including non-coding RNAs.

scholarly journals Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

2012 ◽  
Vol 1 ◽  
pp. e16 ◽  
Author(s):  
Stuart Knowling ◽  
Kenneth Stapleton ◽  
Anne-Marie W Turner ◽  
Eugen Uhlmann ◽  
Thomas Lehmann ◽  
...  
Keyword(s):  
Human Cells ◽  
Modified Oligonucleotides ◽  
Chemically Modified ◽  
Transient Form ◽  
Hiv 1
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