Tuning the Release Rate of Acidic Degradation Products through Macromolecular Design of Caprolactone-Based Copolymers

2007 ◽  
Vol 129 (19) ◽  
pp. 6308-6312 ◽  
Author(s):  
Minna Hakkarainen ◽  
Anders Höglund ◽  
Karin Odelius ◽  
Ann-Christine Albertsson
Keyword(s):  
Release Rate ◽  
Degradation Products ◽  
Acidic Degradation

Solid supported in situ derivatization extraction of acidic degradation products of nerve agents from aqueous samples

2014 ◽  
Vol 1359 ◽  
pp. 325-329 ◽  
Author(s):  
Sridhar Chinthakindi ◽  
Ajay Purohit ◽  
Varoon singh ◽  
Vijay Tak ◽  
D.K. Dubey ◽  
...  
Keyword(s):  
Degradation Products ◽  
Nerve Agents ◽  
Aqueous Samples ◽  
Acidic Degradation ◽  
In Situ Derivatization

scholarly journals Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Yixiu Liu ◽  
Xizhuang Bai ◽  
A. Liang
Keyword(s):  
Ring Opening ◽  
Degradation Products ◽  
Hydrolytic Degradation ◽  
Ring Opening Polymerization ◽  
Random Copolymers ◽  
Thermal And Mechanical Properties ◽  
Degradation Rates ◽  
Synthesis Properties ◽  
Acidic Degradation

Random copolymers of poly(d,l-lactide-co-glycolide-co-ε-caprolactone) (PLGC) were synthesized by the ring-opening polymerization of d,l-lactide (DLLA), glycolide (GA), andε-caprolactone (CL). The effects of CL on the copolymers were evaluated to prepare suitable copolymers with controlled properties. Our results showed that the CL content significantly influenced the thermal and mechanical properties of the copolymers and that the CL content in compositions could be altered to control properties of random copolymers. The in vitro hydrolytic degradation of the resulting implants showed that the degradation rate of PLGC was lower than that of PLGA, which could markedly reduce acidic degradation products. Finally, we demonstrated that higher CL contents in compositions slowed degradation rates.

scholarly journals Biocompatibility, degradability, bioactivity and osteogenesis of mesoporous/macroporous scaffolds of mesoporous diopside/poly( l -lactide) composite

2015 ◽  
Vol 12 (111) ◽  
pp. 20150507 ◽  
Author(s):  
Zhulin Liu ◽  
Jiajin Ji ◽  
Songchao Tang ◽  
Jun Qian ◽  
Yonggang Yan ◽  
...  
Keyword(s):  
Degradation Products ◽  
Immunohistochemical Analysis ◽  
Solution Casting ◽  
Macroporous Structure ◽  
New Bone Formation ◽  
Composite Scaffolds ◽  
Good Biocompatibility ◽  
Particulate Leaching ◽  
Acidic Degradation

Bioactive mesoporous diopside (m-DP) and poly( l -lactide) (PLLA) composite scaffolds with mesoporous/macroporous structure were prepared by the solution-casting and particulate-leaching method. The results demonstrated that the degradability and bioactivity of the mesoporous/macroporous scaffolds were significantly improved by incorporating m-DP into PLLA, and that the improvement was m-DP content-dependent. In addition, the scaffolds containing m-DP showed the ability to neutralize acidic degradation products and prevent the pH from dropping in the solution during the soaking period. Moreover, the scaffolds containing m-DP enhanced attachment, proliferation and alkaline phosphatase activity of MC3T3-E1 cells, which were also m-DP content-dependent. Furthermore, the histological and immunohistochemical analysis results showed that the scaffolds with m-DP significantly promoted new bone formation and improved the materials degraded in vivo , indicating good biocompatibility. The results suggested that the mesoporous/macroporous scaffolds of the m-DP/PLLA composite with osteogenesis had a potential for bone regeneration.

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