Site-Specific Cleavage of RNA by a Metal-Free Artificial Nuclease Attached to Antisense Oligonucleotides

2006 ◽  
Vol 128 (24) ◽  
pp. 8063-8067 ◽  
Author(s):  
Claudio Gnaccarini ◽  
Sascha Peter ◽  
Ute Scheffer ◽  
Stefan Vonhoff ◽  
Sven Klussmann ◽  
...  
Keyword(s):  
Antisense Oligonucleotides ◽  
Site Specific ◽  
Metal Free ◽  
Artificial Nuclease

scholarly journals Antisense Oligonucleotides Containing an Internal, Non-Nucleotide-Based Linker Promote Site-Specific Cleavage of RNA

1996 ◽  
Vol 24 (4) ◽  
pp. 760-765 ◽  
Author(s):  
M. A. Reynolds ◽  
T. A. Beck ◽  
P. B. Say ◽  
D. A. Schwartz ◽  
B. P. Dwyer ◽  
...  
Keyword(s):  
Antisense Oligonucleotides ◽  
Site Specific

A Synthetic Method for Site‐Specific Functionalized Polypeptides: Metal‐Free, Highly Active, and Selective at Room Temperature

2020 ◽  
Vol 60 (2) ◽  
pp. 889-895
Author(s):  
Wei Zhao ◽  
Yanfeng Lv ◽  
Ji Li ◽  
Zihao Feng ◽  
Yonghao Ni ◽  
...  
Keyword(s):  
Room Temperature ◽  
Synthetic Method ◽  
Site Specific ◽  
Metal Free ◽  
Highly Active

A mild, general, and metal-free method for site-specific deuteration induced by visible light using D2O as the source of deuterium atoms

2020 ◽  
Vol 22 (3) ◽  
pp. 669-672 ◽  
Author(s):  
Shuai Shi ◽  
Ruining Li ◽  
Liangming Rao ◽  
Zhankui Sun
Keyword(s):  
Visible Light ◽  
Functional Group ◽  
Site Specific ◽  
Metal Free ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Radical Approach

Visible light induced desulfurization–deuteration method was developed using D2O as the source of deuterium atoms. This radical approach features mild conditions, broad substrate scope, highly efficient D-incorporation and excellent functional group compatibility.

Peroxide-mediated site-specific C–H methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones under metal-free conditions

2020 ◽  
Vol 18 (2) ◽  
pp. 205-210 ◽  
Author(s):  
Shengzhou Jin ◽  
Hua Yao ◽  
Sen Lin ◽  
Xiaoqing You ◽  
Yao Yang ◽  
...  
Keyword(s):  
Site Specific ◽  
Metal Free

An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free conditions is described.

scholarly journals A Synthetic Method for Site‐Specific Functionalized Polypeptides: Metal‐Free, Highly Active, and Selective at Room Temperature

2020 ◽  
Vol 133 (2) ◽  
pp. 902-908
Author(s):  
Wei Zhao ◽  
Yanfeng Lv ◽  
Ji Li ◽  
Zihao Feng ◽  
Yonghao Ni ◽  
...  
Keyword(s):  
Room Temperature ◽  
Synthetic Method ◽  
Site Specific ◽  
Metal Free ◽  
Highly Active

Site-specific hydroxyalkylation of chromones via alcohol mediated Minisci-type radical conjugate addition

2018 ◽  
Vol 16 (11) ◽  
pp. 1823-1827 ◽  
Author(s):  
Rongzhen Chen ◽  
Jin-Tao Yu ◽  
Jiang Cheng
Keyword(s):  
Conjugate Addition ◽  
Site Specific ◽  
Metal Free ◽  
Type Radical

The metal-free C2-functionalization of chromones with alcohols and ethers via radical sp3 C–H activation was developed.

Cleavage of Supercoiled Plasmid DNA by Phenanthroline–Polyamine Conjugates as a Metal-free Artificial Nuclease

2013 ◽  
Vol 42 (1) ◽  
pp. 86-88 ◽  
Author(s):  
Tomokazu Masuda ◽  
Takeshi Sasagase ◽  
Akiko N. Ozaki ◽  
Masayasu Kuwahara ◽  
Hiroaki Ozaki ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Metal Free ◽  
Supercoiled Plasmid ◽  
Artificial Nuclease ◽  
Polyamine Conjugates

Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐ C ‐hydroxymethyl‐β‐ d ‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing

2020 ◽  
Vol 26 (6) ◽  
pp. 1368-1379
Author(s):  
Mathias B. Danielsen ◽  
Chenguang Lou ◽  
Jolanta Lisowiec‐Wachnicka ◽  
Anna Pasternak ◽  
Per T. Jørgensen ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Antisense Oligonucleotides ◽  
Rnase H ◽  
Site Specific
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