DDQ-Mediated Direct Cross-Dehydrogenative-Coupling (CDC) between Benzyl Ethers and Simple Ketones

2006 ◽  
Vol 128 (13) ◽  
pp. 4242-4243 ◽  
Author(s):  
Yuhua Zhang ◽  
Chao-Jun Li
Keyword(s):  
Dehydrogenative Coupling ◽  
Direct Cross ◽  
Benzyl Ethers

Direct cross-dehydrogenative coupling reactions of imidazopyridines and 1-naphthylamines with ethers under metal-free conditions

2020 ◽  
Vol 50 (13) ◽  
pp. 1972-1981
Author(s):  
Zhe Dong ◽  
Yu Liu ◽  
Chen-Wei Zhou ◽  
Jun-Jian Huang ◽  
Tao Guo ◽  
...  
Keyword(s):  
Coupling Reactions ◽  
Metal Free ◽  
Dehydrogenative Coupling ◽  
Direct Cross

scholarly journals Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines

2019 ◽  
Vol 10 (8) ◽  
pp. 2264-2271 ◽  
Author(s):  
Rachel Grainger ◽  
Tom D. Heightman ◽  
Steven V. Ley ◽  
Fabio Lima ◽  
Christopher N. Johnson
Keyword(s):  
Drug Discovery ◽  
Cyclic Amines ◽  
Dehydrogenative Coupling ◽  
Direct Cross ◽  
Fragment Based Drug Discovery ◽  
Synthetic Transformations

A nanogram-to-gram workflow has been established for the identification and development of synthetic transformations which are enabling in Fragment-Based Drug Discovery (FBDD). In this study, we disclose a method for the synthesis of privileged sp2–sp3 architectures via direct cross-dehydrogenative coupling of heterocycles.

Catalyst-free direct cross-dehydrogenative coupling of imidazoheterocycles with glyoxal hydrates: an efficient approach to 1,2-diketones

2019 ◽  
Vol 17 (12) ◽  
pp. 3150-3158 ◽  
Author(s):  
Tao Guo ◽  
Xiang-Heng Fu ◽  
Miao Zhang ◽  
Yu-Liu Li ◽  
Yong-Cheng Ma
Keyword(s):  
Efficient Approach ◽  
Catalyst Free ◽  
Dehydrogenative Coupling ◽  
Direct Cross

An efficient and convenient catalyst-free synthesis of 1,2-diketones via cross-dehydrogenative coupling of imidazoheterocycles with glyoxal hydrates is described.

Metal-free iodine-catalyzed direct cross-dehydrogenative coupling (CDC) between pyrazoles and thiols

2016 ◽  
Vol 3 (11) ◽  
pp. 1457-1461 ◽  
Author(s):  
Daoshan Yang ◽  
Pengfei Sun ◽  
Wei Wei ◽  
Lingduan Meng ◽  
Lingchao He ◽  
...  
Keyword(s):  
Coupling Method ◽  
Metal Free ◽  
Dehydrogenative Coupling ◽  
Direct Cross ◽  
Free Iodine

A green and efficient iodine-catalyzed cross-dehydrogenative C–S coupling method for the synthesis of C-4 sulfenylated pyrazoles has been initially developed under metal-free conditions.

Photoredox-Mediated Direct Cross-Dehydrogenative Coupling of Heteroarenes and Amines

2018 ◽  
Vol 20 (18) ◽  
pp. 5661-5665 ◽  
Author(s):  
Jianyang Dong ◽  
Qing Xia ◽  
Xueli Lv ◽  
Changcun Yan ◽  
Hongjian Song ◽  
...  
Keyword(s):  
Dehydrogenative Coupling ◽  
Direct Cross

Transition-metal-free direct cross-dehydrogenative coupling reactions of quinolinones with ethers

2020 ◽  
Vol 61 (4) ◽  
pp. 151426
Author(s):  
Gang Wang ◽  
Jun-Tao Wang ◽  
Bing Zhao ◽  
Huan Chen ◽  
Pan-Ke Zhang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Coupling Reactions ◽  
Metal Free ◽  
Dehydrogenative Coupling ◽  
Direct Cross

Thermally-Induced Dehydrogenative Coupling of Organosilanes and H-Terminated Silicon Quantum Dots onto Germanane Surfaces

2020 ◽  
Author(s):  
Haoyang Yu ◽  
Alyxandra Thiessen ◽  
Md Asjad Hossain ◽  
Marc Julian Kloberg ◽  
Bernhard Rieger ◽  
...  
Keyword(s):  
2D Materials ◽  
Future Generation ◽  
Optical Devices ◽  
Surface Reactivity ◽  
Organic Monolayers ◽  
Present Contribution ◽  
Thermally Induced ◽  
Dehydrogenative Coupling ◽  
Silicon Quantum Dot ◽  
Covalently Bonded

<div><div><div><p>Covalently bonded organic monolayers play important roles in defining the solution processability, ambient stability, and electronic properties of two-dimensional (2D) materials such as Ge nanosheets (GeNSs); they also hold promise of providing avenues for the fabrication of future generation electronic and optical devices. Functionalization of GeNS normally involves surface moieties linked through covalent Ge−C bonds. In the present contribution we extend the scope of surface linkages to include Si−Ge bonding and present the first demonstration of heteronuclear dehydrocoupling of organosilanes to hydride-terminated GeNSs obtained from the deintercalation and exfoliation of CaGe2. We further exploit this new surface reactivity and demonstrated the preparation of directly bonded silicon quantum dot-Ge nanosheet hybrids.</p></div></div></div>

Visible Light-Mediated Oxidative Debenzylation

2020 ◽  
Author(s):  
Cristian Cavedon ◽  
Eric T. Sletten ◽  
Amiera Madani ◽  
Olaf Niemeyer ◽  
Peter H. Seeberger ◽  
...  
Keyword(s):  
Reaction Time ◽  
Visible Light ◽  
Functional Groups ◽  
Continuous Flow ◽  
Protecting Groups ◽  
Benzyl Ether ◽  
Complex Molecules ◽  
Protective Groups ◽  
Benzyl Ethers ◽  
Harsh Conditions

Protecting groups are key in the synthesis of complex molecules such as carbohydrates to distinguish functional groups of similar reactivity. The harsh conditions required to cleave stable benzyl ether protective groups are not compatible with many other protective and functional groups. The mild, visible light-mediated debenzylation disclosed here renders benzyl ethers orthogonal protective groups. Key to success is the use of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as stoichiometric or catalytic photooxidant such that benzyl ethers can be cleaved in the presence of azides, alkenes, and alkynes. The reaction time for this transformation can be reduced from hours to minutes in continuous flow. <br>

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