scholarly journals Rh(III)-catalyzed direct cross-dehydrogenative coupling of aromatic nitriles with heteroarenes: Rapid access to biheteroaryl-2-carbonitriles

2020 ◽  
Vol 1 (2) ◽  
pp. 167-170
Author(s):  
Huibei Xu ◽  
Yanying Zhu ◽  
Xinyue Chai ◽  
Jiahui Yang ◽  
Lin Dong
Keyword(s):  
Aromatic Nitriles ◽  
Rapid Access ◽  
Dehydrogenative Coupling ◽  
Direct Cross

Direct cross-dehydrogenative coupling reactions of imidazopyridines and 1-naphthylamines with ethers under metal-free conditions

2020 ◽  
Vol 50 (13) ◽  
pp. 1972-1981
Author(s):  
Zhe Dong ◽  
Yu Liu ◽  
Chen-Wei Zhou ◽  
Jun-Jian Huang ◽  
Tao Guo ◽  
...  
Keyword(s):  
Coupling Reactions ◽  
Metal Free ◽  
Dehydrogenative Coupling ◽  
Direct Cross

scholarly journals Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines

2019 ◽  
Vol 10 (8) ◽  
pp. 2264-2271 ◽  
Author(s):  
Rachel Grainger ◽  
Tom D. Heightman ◽  
Steven V. Ley ◽  
Fabio Lima ◽  
Christopher N. Johnson
Keyword(s):  
Drug Discovery ◽  
Cyclic Amines ◽  
Dehydrogenative Coupling ◽  
Direct Cross ◽  
Fragment Based Drug Discovery ◽  
Synthetic Transformations

A nanogram-to-gram workflow has been established for the identification and development of synthetic transformations which are enabling in Fragment-Based Drug Discovery (FBDD). In this study, we disclose a method for the synthesis of privileged sp2–sp3 architectures via direct cross-dehydrogenative coupling of heterocycles.

Catalyst-free direct cross-dehydrogenative coupling of imidazoheterocycles with glyoxal hydrates: an efficient approach to 1,2-diketones

2019 ◽  
Vol 17 (12) ◽  
pp. 3150-3158 ◽  
Author(s):  
Tao Guo ◽  
Xiang-Heng Fu ◽  
Miao Zhang ◽  
Yu-Liu Li ◽  
Yong-Cheng Ma
Keyword(s):  
Efficient Approach ◽  
Catalyst Free ◽  
Dehydrogenative Coupling ◽  
Direct Cross

An efficient and convenient catalyst-free synthesis of 1,2-diketones via cross-dehydrogenative coupling of imidazoheterocycles with glyoxal hydrates is described.

Metal-free iodine-catalyzed direct cross-dehydrogenative coupling (CDC) between pyrazoles and thiols

2016 ◽  
Vol 3 (11) ◽  
pp. 1457-1461 ◽  
Author(s):  
Daoshan Yang ◽  
Pengfei Sun ◽  
Wei Wei ◽  
Lingduan Meng ◽  
Lingchao He ◽  
...  
Keyword(s):  
Coupling Method ◽  
Metal Free ◽  
Dehydrogenative Coupling ◽  
Direct Cross ◽  
Free Iodine

A green and efficient iodine-catalyzed cross-dehydrogenative C–S coupling method for the synthesis of C-4 sulfenylated pyrazoles has been initially developed under metal-free conditions.

I2-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones

2017 ◽  
Vol 15 (41) ◽  
pp. 8770-8779 ◽  
Author(s):  
Kaili Chen ◽  
Biao Gao ◽  
Yanguo Shang ◽  
Jianyao Du ◽  
Qinlan Gu ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Rapid Access ◽  
Dehydrogenative Coupling ◽  
First Time

An efficient and applicable I2-catalyzed intramolecular dehydrogenative C–O/C–N coupling reaction has been developed for the first time to provide both benzoxazinones and quinazolinones.

Organocatalyzed cross-dehydrogenative coupling for C(sp3)–O bonds formation: a rapid access to α-aminoxyl isochromans

2019 ◽  
Vol 149 (2) ◽  
pp. 574-579 ◽  
Author(s):  
Yuli Zhou ◽  
Jingwen Chen ◽  
Ahmed Ali Elsayed ◽  
Zhiguo Zhang ◽  
Zongbi Bao ◽  
...  
Keyword(s):  
Rapid Access ◽  
Dehydrogenative Coupling

Palladium-catalyzed dehydrogenative coupling of cyclic enones with thiophenes: a rapid access to β-heteroarylated cyclic enones

2018 ◽  
Vol 54 (29) ◽  
pp. 3668-3671 ◽  
Author(s):  
Zhen-Kang Wen ◽  
Ting-Ting Song ◽  
Yu-Fang Liu ◽  
Jian-Bin Chao
Keyword(s):  
Coupling Reaction ◽  
Rapid Access ◽  
Dehydrogenative Coupling ◽  
Cyclic Enones ◽  
Palladium Catalyzed

A dehydrogenative coupling reaction of cyclic enones with thiophenes through palladium-catalyzed C–H functionalization is reported herein. Further molecular transformations of the coupling products to synthetically useful meta-heteroarylated phenols are also demonstrated.

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