Substituted Carborane-Appended Water-Soluble Single-Wall Carbon Nanotubes:  New Approach to Boron Neutron Capture Therapy Drug Delivery

2005 ◽  
Vol 127 (27) ◽  
pp. 9875-9880 ◽  
Author(s):  
Zhu Yinghuai ◽  
Ang Thiam Peng ◽  
Keith Carpenter ◽  
John A. Maguire ◽  
Narayan S. Hosmane ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Water Soluble ◽  
Single Wall Carbon Nanotubes ◽  
Neutron Capture Therapy ◽  
New Approach ◽  
Single Wall Carbon ◽  
Boron Neutron Capture

scholarly journals Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1953
Author(s):  
Ghadir Kalot ◽  
Amélie Godard ◽  
Benoît Busser ◽  
Jacques Pliquett ◽  
Mans Broekgaarden ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Ex Vivo ◽  
Chorioallantoic Membrane ◽  
Water Soluble ◽  
Neutron Capture Therapy ◽  
Breakdown Spectroscopy ◽  
Boron Neutron Capture ◽  
Tumor Area ◽  
Slow Neutrons

Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on the nuclear capture of slow neutrons by stable 10B atoms followed by charged particle emission that inducing extensive damage on a very localized level (<10 μm). To be efficient, a sufficient amount of 10B should accumulate in the tumor area while being almost cleared from the normal surroundings. A water-soluble aza-boron-dipyrromethene dyes (BODIPY) fluorophore was reported to strongly accumulate in the tumor area with high and BNCT compatible Tumor/Healthy Tissue ratios. The clinically used 10B-BSH (sodium borocaptate) was coupled to the water-soluble aza-BODIPY platform for enhanced 10B-BSH tumor vectorization. We demonstrated a strong uptake of the compound in tumor cells and determined its biodistribution in mice-bearing tumors. A model of chorioallantoic membrane-bearing glioblastoma xenograft was developed to evidence the BNCT potential of such compound, by subjecting it to slow neutrons. We demonstrated the tumor accumulation of the compound in real-time using optical imaging and ex vivo using elemental imaging based on laser-induced breakdown spectroscopy. The tumor growth was significantly reduced as compared to BNCT with 10B-BSH. Altogether, the fluorescent aza-BODIPY/10B-BSH compound is able to vectorize and image the 10B-BSH in the tumor area, increasing its theranostic potential for efficient approach of BNCT.

scholarly journals DDIS-20. NEW A6K BORON DRUG DELIVERY SYSTEM FOR CLINICAL APPLICATION OF BORON NEUTRON CAPTURE THERAPY (BNCT)

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi73-vi73
Author(s):  
Hiroyuki Michiue ◽  
Asami Fukunaga ◽  
Atsushi Fujimura ◽  
Kazuyo Igawa ◽  
Hideki Matsui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Clinical Application ◽  
Delivery System ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture
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