scholarly journals Drug Delivery: Highly Condensed Boron Cage Cluster Anions in 2D Carrier and Its Enhanced Antitumor Efficiency for Boron Neutron Capture Therapy (Adv. Funct. Mater. 27/2018)

2018 ◽  
Vol 28 (27) ◽  
pp. 1870182
Author(s):  
Goeun Choi ◽  
Ie-Rang Jeon ◽  
Huiyan Piao ◽  
Jin-Ho Choy
Keyword(s):  
Drug Delivery ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Cluster Anions ◽  
Boron Neutron Capture

scholarly journals DDIS-20. NEW A6K BORON DRUG DELIVERY SYSTEM FOR CLINICAL APPLICATION OF BORON NEUTRON CAPTURE THERAPY (BNCT)

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi73-vi73
Author(s):  
Hiroyuki Michiue ◽  
Asami Fukunaga ◽  
Atsushi Fujimura ◽  
Kazuyo Igawa ◽  
Hideki Matsui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Clinical Application ◽  
Delivery System ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals Boron rich nanotube drug carrier system is suited for boron neutron capture therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fabian Heide ◽  
Matthew McDougall ◽  
Candice Harder-Viddal ◽  
Roy Roshko ◽  
David Davidson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Drug Carrier ◽  
Integrative Approach ◽  
Target Cells ◽  
Neutron Capture Therapy ◽  
Excellent Thermal Stability ◽  
Boron Neutron Capture

AbstractBoron neutron capture therapy (BNCT) is a two-step therapeutic process that utilizes Boron-10 in combination with low energy neutrons to effectively eliminate targeted cells. This therapy is primarily used for difficult to treat head and neck carcinomas; recent advances have expanded this method to cover a broader range of carcinomas. However, it still remains an unconventional therapy where one of the barriers for widespread adoption is the adequate delivery of Boron-10 to target cells. In an effort to address this issue, we examined a unique nanoparticle drug delivery system based on a highly stable and modular proteinaceous nanotube. Initially, we confirmed and structurally analyzed ortho-carborane binding into the cavities of the nanotube. The high ratio of Boron to proteinaceous mass and excellent thermal stability suggest the nanotube system as a suitable candidate for drug delivery into cancer cells. The full physicochemical characterization of the nanotube then allowed for further mechanistic molecular dynamic studies of the ortho-carborane uptake and calculations of corresponding energy profiles. Visualization of the binding event highlighted the protein dynamics and the importance of the interhelical channel formation to allow movement of the boron cluster into the nanotube. Additionally, cell assays showed that the nanotube can penetrate outer membranes of cancer cells followed by localization around the cells’ nuclei. This work uses an integrative approach combining experimental data from structural, molecular dynamics simulations and biological experiments to thoroughly present an alternative drug delivery device for BNCT which offers additional benefits over current delivery methods.

Application of drug delivery system to boron neutron capture therapy for cancer

2008 ◽  
Vol 5 (4) ◽  
pp. 427-443 ◽  
Author(s):  
Hironobu Yanagië ◽  
Aya Ogata ◽  
Hirotaka Sugiyama ◽  
Masazumi Eriguchi ◽  
Shinichi Takamoto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture
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