Origin of Tight Binding of a Near-Perfect Transition-State Analogue by Cytidine Deaminase:  Implications for Enzyme Catalysis

Haobo Guo; Niny Rao; Qin Xu; Hong Guo

doi:10.1021/ja0439625

Origin of Tight Binding of a Near-Perfect Transition-State Analogue by Cytidine Deaminase: Implications for Enzyme Catalysis

Journal of the American Chemical Society ◽

10.1021/ja0439625 ◽

2005 ◽

Vol 127 (9) ◽

pp. 3191-3197 ◽

Cited By ~ 28

Author(s):

Haobo Guo ◽

Niny Rao ◽

Qin Xu ◽

Hong Guo

Keyword(s):

Transition State ◽

Enzyme Catalysis ◽

Cytidine Deaminase ◽

Tight Binding ◽

Transition State Analogue

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Flight of a Cytidine Deaminase Complex with an Imperfect Transition State Analogue Inhibitor: Mass Spectrometric Evidence for the Presence of a Trapped Water Molecule

Biochemistry ◽

10.1021/bi300516u ◽

2012 ◽

Vol 51 (32) ◽

pp. 6476-6486 ◽

Cited By ~ 5

Author(s):

Gottfried K. Schroeder ◽

Li Zhou ◽

Mark J. Snider ◽

Xian Chen ◽

Richard Wolfenden

Keyword(s):

Water Molecule ◽

Transition State ◽

Cytidine Deaminase ◽

Mass Spectrometric ◽

Transition State Analogue ◽

Mass Spectrometric Evidence

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Effect of alcohol configuration on tight binding inhibition of HIV protease by hydroxyethylamine transition-state analogue inhibitors

Peptides 1990 ◽

10.1007/978-94-011-3034-9_327 ◽

1991 ◽

pp. 790-791

Author(s):

Daniel H. Rich ◽

Jeremy Green ◽

J. V. N. Vara Prasad ◽

C. Q. Sun ◽

Mihaly Toth ◽

...

Keyword(s):

Transition State ◽

Tight Binding ◽

Hiv Protease ◽

Transition State Analogue ◽

Binding Inhibition ◽

Transition State Analogue Inhibitors

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Role of Glutamate-104 in Generating a Transition State Analogue Inhibitor at the Active Site of Cytidine Deaminase†

Biochemistry ◽

10.1021/bi951498y ◽

1996 ◽

Vol 35 (3) ◽

pp. 948-954 ◽

Cited By ~ 20

Author(s):

Dean C. Carlow ◽

Steven A. Short ◽

Richard Wolfenden

Keyword(s):

Transition State ◽

Active Site ◽

Cytidine Deaminase ◽

Transition State Analogue

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A Slow-Tight Binding Inhibitor of Dopamine β-Monooxygenase: A Transition State Analogue for the Product Release Step†

Biochemistry ◽

10.1021/bi0262606 ◽

2002 ◽

Vol 41 (41) ◽

pp. 12414-12420 ◽

Cited By ~ 7

Author(s):

Sanjeewa P. Dharmasena ◽

D. Shyamali Wimalasena ◽

Kandatege Wimalasena

Keyword(s):

Transition State ◽

Tight Binding ◽

Product Release ◽

Transition State Analogue

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Ketone-substrate analogues of Clostridium histolyticum collagenases: tight-binding transition-state analogue inhibitors

Biochemistry ◽

10.1021/bi00412a016 ◽

1988 ◽

Vol 27 (12) ◽

pp. 4299-4304 ◽

Cited By ~ 9

Author(s):

Kasim A. Mookhtiar ◽

Damian Grobelny ◽

Richard E. Galardy ◽

Harold E. Van Wart

Keyword(s):

Transition State ◽

Tight Binding ◽

Clostridium Histolyticum ◽

Substrate Analogues ◽

Transition State Analogue ◽

Transition State Analogue Inhibitors

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Faculty Opinions recommendation of L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1097544.553622 ◽

2008 ◽

Author(s):

Wayne Guida

Keyword(s):

Transition State ◽

Purine Nucleoside Phosphorylase ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase ◽

Transition State Analogue ◽

Transition State Analogue Inhibitors

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Crystallization and preliminary x-ray studies of spinach ribulose 1,5-bisphosphate carboxylase/oxygenase complexed with activator and a transition state analogue.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)43825-7 ◽

1983 ◽

Vol 258 (23) ◽

pp. 14088-14090

Author(s):

I Andersson ◽

A C Tjäder ◽

E Cedergren-Zeppezauer ◽

C I Brändén

Keyword(s):

Transition State ◽

Bisphosphate Carboxylase ◽

X Ray ◽

Transition State Analogue

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A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.08.121 ◽

2006 ◽

Vol 16 (23) ◽

pp. 6039-6042 ◽

Cited By ~ 14

Author(s):

Swati S. More ◽

Robert Vince

Keyword(s):

Transition State ◽

Tight Binding ◽

Glyoxalase I

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ChemInform Abstract: SYNTHESIS OF 1,3-DIAZEPIN-2-ONE NUCLEOSIDES AS TRANSITION-STATE INHIBITORS OF CYTIDINE DEAMINASE

Chemischer Informationsdienst ◽

10.1002/chin.198048213 ◽

1980 ◽

Vol 11 (48) ◽

Author(s):

V. E. MARQUEZ ◽

P. S. LIU ◽

J. A. KELLEY ◽

J. S. DRISCOLL ◽

J. J. MCCORMACK

Keyword(s):

Transition State ◽

Cytidine Deaminase

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Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue

Science ◽

10.1126/science.2274787 ◽

1990 ◽

Vol 250 (4987) ◽

pp. 1560-1563 ◽

Cited By ~ 227

Author(s):

S. White ◽

D. Scott ◽

Z. Otwinowski ◽

M. Gelb ◽

P. Sigler

Keyword(s):

Crystal Structure ◽

Transition State ◽

Phospholipase A2 ◽

Cobra Venom ◽

Transition State Analogue

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