Development of a New Family of Conformationally Restricted Peptides as Potent Nucleators of β-Turns. Design, Synthesis, Structure, and Biological Evaluation of a β-Lactam Peptide Analogue of Melanostatin

2003 ◽  
Vol 125 (52) ◽  
pp. 16243-16260 ◽  
Author(s):  
Claudio Palomo ◽  
Jesus M. Aizpurua ◽  
Ana Benito ◽  
José Ignacio Miranda ◽  
Raluca M. Fratila ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Peptide Analogue ◽  
Conformationally Restricted ◽  
New Family

Design, Synthesis, and Biological Evaluation of Conformationally Restricted Rivastigmine Analogues

2004 ◽  
Vol 47 (24) ◽  
pp. 5945-5952 ◽  
Author(s):  
Maria Laura Bolognesi ◽  
Manuela Bartolini ◽  
Andrea Cavalli ◽  
Vincenza Andrisano ◽  
Michela Rosini ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Conformationally Restricted ◽  
Synthesis And Biological Evaluation

scholarly journals Conformationally restricted quinazolone derivatives as PI3Kδ-selective inhibitors: the design, synthesis and biological evaluation

MedChemComm ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Xiaodong Ma ◽  
Fang Fang ◽  
Qiangqiang Tao ◽  
Li Shen ◽  
Guochen Zhong ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Selective Inhibitors ◽  
Conformational Restriction ◽  
Design Synthesis ◽  
Conformationally Restricted ◽  
Synthesis And Biological Evaluation

A series of structurally novel quinazolone-based PI3Kδ-selective inhibitors were designed and synthesized via the approach of conformational restriction.

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